acompound

Showing entry for L-Targinine

General Compound Information
BXGC Id	BXGC0000247
Compound Name	L-Targinine
Structure
Formula	C7H16N4O2
InchiKey	NTNWOCRCBQPEKQ-YFKPBYRVSA-N
SMILES	CNC(=N)NCCC[C@H](N)C(O)=O
Inchi	InChI=1S/C7H16N4O2/c1-10-7(9)11-4-2-3-5(8)6(12)13/h5H,2-4,8H2,1H3,(H,12,13)(H3,9,10,11)/t5-/m0/s1
IUPAC	(2S)-2-amino-5-(3-methylcarbamimidamido)pentanoic acid
Molecular Weight	188.23
Pubchem Id	132862
Chembl Id	CHEMBL256147

Targets of Information Source

DrugBank

n.a

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type

PDB

NMM

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
Q8N371	BXGT018504	Bifunctional peptidase and arginyl-hydroxylase JMJD5	reviewed	KDM8	-	-	-	-	-
Q6NYC1	BXGT016436	Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6	reviewed	JMJD6	Receptor	-	-	-	-
P61964	BXGT011396	WD repeat-containing protein 5	reviewed	WDR5	-	-	-	-	-
Q6NXT2	BXGT016434	Histone H3.3C	reviewed	H3-5	-	-	-	-	-

Binding DB

92900

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
reviewed	BXGT005328	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	reviewed	Enzyme	DDAH1	-	-	-	-
reviewed	BXGT005328	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	reviewed	Enzyme	DDAH1	131000	-	-	-
reviewed	BXGT009353	Nitric oxide synthase, brain	reviewed		NOS1	2000	-	-	-
reviewed	BXGT009353	Nitric oxide synthase, brain	reviewed		NOS1	-	-	-	-
reviewed	BXGT005328	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	reviewed	Enzyme	DDAH1	1400000	-	-	-
reviewed	BXGT005328	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	reviewed	Enzyme	DDAH1	1200000	-	-	-
reviewed	BXGT005328	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	reviewed	Enzyme	DDAH1	290000	-	-	-
reviewed	BXGT009352	Nitric oxide synthase, endothelial	reviewed		NOS3	-	6000	-	-
reviewed	BXGT009800	Nitric oxide synthase, inducible	reviewed		NOS2	-	27000	-	-
reviewed	BXGT009354	Nitric oxide synthase, brain	reviewed		Nos1	-	7500	-	-
reviewed	BXGT009351	Nitric oxide synthase, endothelial	reviewed		NOS3	-	7000	-	-
reviewed	BXGT009355	Nitric oxide synthase, inducible	reviewed		Nos2	-	25000	-	-
reviewed	BXGT009353	Nitric oxide synthase, brain	reviewed		NOS1	-	2700	-	-
reviewed	BXGT009352	Nitric oxide synthase, endothelial	reviewed		NOS3	-	8700	-	-
reviewed	BXGT009800	Nitric oxide synthase, inducible	reviewed		NOS2	-	10000	-	-
reviewed	BXGT009352	Nitric oxide synthase, endothelial	reviewed		NOS3	-	300	-	-
reviewed	BXGT009800	Nitric oxide synthase, inducible	reviewed		NOS2	-	170000000	-	-
reviewed	BXGT009800	Nitric oxide synthase, inducible	reviewed		NOS2	-	300	-	-
reviewed	BXGT009354	Nitric oxide synthase, brain	reviewed		Nos1	-	100	-	-
reviewed	BXGT009355	Nitric oxide synthase, inducible	reviewed		Nos2	-	19000	-	-
reviewed	BXGT022398	Nitric oxide synthase, brain	reviewed		Nos1	-	4300	-	-
reviewed	BXGT009355	Nitric oxide synthase, inducible	reviewed		Nos2	-	13000	-	-
reviewed	BXGT009355	Nitric oxide synthase, inducible	reviewed		Nos2	-	2300	-	-
reviewed	BXGT009354	Nitric oxide synthase, brain	reviewed		Nos1	-	10000	-	-
reviewed	BXGT009353	Nitric oxide synthase, brain	reviewed		NOS1	840	-	-	-
reviewed	BXGT009800	Nitric oxide synthase, inducible	reviewed		NOS2	860	-	-	-
reviewed	BXGT009352	Nitric oxide synthase, endothelial	reviewed		NOS3	400	-	-	-
reviewed	BXGT009355	Nitric oxide synthase, inducible	reviewed		Nos2	-	22100	-	-
reviewed	BXGT009800	Nitric oxide synthase, inducible	reviewed		NOS2	-	6600	-	-
reviewed	BXGT009352	Nitric oxide synthase, endothelial	reviewed		NOS3	-	3500	-	-
reviewed	BXGT009353	Nitric oxide synthase, brain	reviewed		NOS1	-	4900	-	-
reviewed	BXGT009352	Nitric oxide synthase, endothelial	reviewed		NOS3	-	540	-	-
reviewed	BXGT009353	Nitric oxide synthase, brain	reviewed		NOS1	-	890	-	-
reviewed	BXGT009800	Nitric oxide synthase, inducible	reviewed		NOS2	-	1000	-	-
reviewed	BXGT009352	Nitric oxide synthase, endothelial	reviewed		NOS3	-	5900	-	-
reviewed	BXGT009353	Nitric oxide synthase, brain	reviewed		NOS1	-	10000	-	-
reviewed	BXGT009800	Nitric oxide synthase, inducible	reviewed		NOS2	-	14000	-	-
reviewed	BXGT009353	Nitric oxide synthase, brain	reviewed		NOS1	-	950	-	-
reviewed	BXGT009800	Nitric oxide synthase, inducible	reviewed		NOS2	-	1800	-	-
reviewed	BXGT009353	Nitric oxide synthase, brain	reviewed		NOS1	-	950	-	-
reviewed	BXGT009800	Nitric oxide synthase, inducible	reviewed		NOS2	-	1.8	-	-
reviewed	BXGT009800	Nitric oxide synthase, inducible	reviewed		NOS2	-	1800	-	-
reviewed	BXGT009355	Nitric oxide synthase, inducible	reviewed		Nos2	-	19700	-	-
reviewed	BXGT009354	Nitric oxide synthase, brain	reviewed		Nos1	200	-	-	-
reviewed	BXGT009355	Nitric oxide synthase, inducible	reviewed		Nos2	-	32000	-	-

CHEMBL

CHEMBL256147

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	width="10%">Type	Relation	value	Units
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Type	Relation	value	Units
P35228	BXGT009800	Nitric oxide synthase, inducible	reviewed	-	NOS2	IC50	'='	3400	nM
P29477	BXGT009355	Nitric oxide synthase, inducible	reviewed	-	Nos2	IC50	'='	25000	nM
P33261	BXGT009707	Cytochrome P450 2C19	reviewed	-	CYP2C19	AC50	'='	15848	nM
P29475	BXGT009353	Nitric oxide synthase, brain	reviewed	-	NOS1	IC50	'='	890	nM
O94760	BXGT005328	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	reviewed	Enzyme	DDAH1	Km	'='	190000	nM
O08557	BXGT004030	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	reviewed	-	Ddah1	Kcat/Km	'='	16	/mM/min
O94760	BXGT005328	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	reviewed	Enzyme	DDAH1	Kcat	'='	0	/min
P29477	BXGT009355	Nitric oxide synthase, inducible	reviewed	-	Nos2	IC50	'='	19000	nM
P29476	BXGT009354	Nitric oxide synthase, brain	reviewed	-	Nos1	Ki	'='	200	nM
P29477	BXGT009355	Nitric oxide synthase, inducible	reviewed	-	Nos2	IC50	'='	19700	nM
P05177	BXGT006336	Cytochrome P450 1A2	reviewed	Enzyme	CYP1A2	AC50	'='	31622	nM
P35228	BXGT009800	Nitric oxide synthase, inducible	reviewed	-	NOS2	Selectivity	'='	0	-
P29475	BXGT009353	Nitric oxide synthase, brain	reviewed	-	NOS1	Selectivity	'='	0	-
O08557	BXGT004030	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	reviewed	-	Ddah1	Km	'='	360000	nM
P29474	BXGT009352	Nitric oxide synthase, endothelial	reviewed	-	NOS3	IC50	'='	650	nM
P35228	BXGT009800	Nitric oxide synthase, inducible	reviewed	-	NOS2	Ratio	'='	0	-
P29475	BXGT009353	Nitric oxide synthase, brain	reviewed	-	NOS1	Ratio	'='	0	-
P35228	BXGT009800	Nitric oxide synthase, inducible	reviewed	-	NOS2	IC50	'='	1000	nM
Q9Z0J4	BXGT022398	Nitric oxide synthase, brain	reviewed	-	Nos1	IC50	'='	4300	nM
P29475	BXGT009353	Nitric oxide synthase, brain	reviewed	-	NOS1	IC50	'='	2700	nM
P10635	BXGT007595	Cytochrome P450 2D6	reviewed	-	CYP2D6	AC50	-	-	-
P08684	BXGT006812	Cytochrome P450 3A4	reviewed	Enzyme	CYP3A4	AC50	-	-	-
P29476	BXGT009354	Nitric oxide synthase, brain	reviewed	-	Nos1	IC50	'='	10000	nM
P35228	BXGT009800	Nitric oxide synthase, inducible	reviewed	-	NOS2	IC50	'='	10000	nM
P29474	BXGT009352	Nitric oxide synthase, endothelial	reviewed	-	NOS3	IC50	'='	540	nM
O94760	BXGT005328	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	reviewed	Enzyme	DDAH1	Kcat/Km	'='	9	/mM/min
P35228	BXGT009800	Nitric oxide synthase, inducible	reviewed	-	NOS2	Ki	'='	860	nM
P35228	BXGT009800	Nitric oxide synthase, inducible	reviewed	-	NOS2	Selectivity	'='	1	-
P29475	BXGT009353	Nitric oxide synthase, brain	reviewed	-	NOS1	Selectivity	'='	1	-
P29476	BXGT009354	Nitric oxide synthase, brain	reviewed	-	Nos1	IC50	'='	100	nM
O94760	BXGT005328	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	reviewed	Enzyme	DDAH1	Kcat	'='	0	/min
O94760	BXGT005328	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	reviewed	Enzyme	DDAH1	Km	'='	90000	nM
P05177	BXGT006336	Cytochrome P450 1A2	reviewed	Enzyme	CYP1A2	AC50	-	-	-
P29474	BXGT009352	Nitric oxide synthase, endothelial	reviewed	-	NOS3	Ratio	'='	0	-
P35228	BXGT009800	Nitric oxide synthase, inducible	reviewed	-	NOS2	Ratio	'='	0	-
O94760	BXGT005328	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	reviewed	Enzyme	DDAH1	Vmax	'='	154	nmol/min/mg
P29474	BXGT009352	Nitric oxide synthase, endothelial	reviewed	-	NOS3	Ki	'='	400	nM
P35228	BXGT009800	Nitric oxide synthase, inducible	reviewed	-	NOS2	IC50	'='	14000	nM
P29475	BXGT009353	Nitric oxide synthase, brain	reviewed	-	NOS1	IC50	'='	10000	nM
P29474	BXGT009352	Nitric oxide synthase, endothelial	reviewed	-	NOS3	Selectivity	'='	0	-
P29475	BXGT009353	Nitric oxide synthase, brain	reviewed	-	NOS1	Selectivity	'='	0	-
O94760	BXGT005328	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	reviewed	Enzyme	DDAH1	Kcat/Km	'='	2	/mM/min
P33261	BXGT009707	Cytochrome P450 2C19	reviewed	-	CYP2C19	Potency	'='	15848	nM
P29474	BXGT009352	Nitric oxide synthase, endothelial	reviewed	-	NOS3	Selectivity	'='	0	-
P29475	BXGT009353	Nitric oxide synthase, brain	reviewed	-	NOS1	Selectivity	'='	0	-
P29475	BXGT009353	Nitric oxide synthase, brain	reviewed	-	NOS1	IC50	'='	4900	nM
P29474	BXGT009352	Nitric oxide synthase, endothelial	reviewed	-	NOS3	IC50	'='	8700	nM
P29474	BXGT009352	Nitric oxide synthase, endothelial	reviewed	-	NOS3	Selectivity ratio	'='	0	-
P35228	BXGT009800	Nitric oxide synthase, inducible	reviewed	-	NOS2	Selectivity ratio	'='	0	-
P29477	BXGT009355	Nitric oxide synthase, inducible	reviewed	-	Nos2	IC50	'='	22100	nM
P35228	BXGT009800	Nitric oxide synthase, inducible	reviewed	-	NOS2	IC50	'='	1800	nM
P08659	BXGT006805	Luciferin 4-monooxygenase	reviewed	-		Potency	-	40533	nM
P29473	BXGT009351	Nitric oxide synthase, endothelial	reviewed	-	NOS3	IC50	'='	7000	nM
Q96KQ7	BXGT019687	Histone-lysine N-methyltransferase EHMT2	reviewed	Epigenetic regulator	EHMT2	Potency	-	39810	nM
P35228	BXGT009800	Nitric oxide synthase, inducible	reviewed	-	NOS2	IC50	'='	27000	nM
P29474	BXGT009352	Nitric oxide synthase, endothelial	reviewed	-	NOS3	IC50	'='	6000	nM
P29474	BXGT009352	Nitric oxide synthase, endothelial	reviewed	-	NOS3	IC50	'='	5900	nM
O94760	BXGT005328	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	reviewed	Enzyme	DDAH1	Km	'='	106000	nM
P29475	BXGT009353	Nitric oxide synthase, brain	reviewed	-	NOS1	Ki	'='	840	nM
P29474	BXGT009352	Nitric oxide synthase, endothelial	reviewed	-	NOS3	IC50	'='	300	nM
P11712	BXGT007738	Cytochrome P450 2C9	reviewed	-	CYP2C9	AC50	-	-	-
Q12809	BXGT013267	Potassium voltage-gated channel subfamily H member 2	reviewed	Ion channel	KCNH2	EC50	-	-	-
P29476	BXGT009354	Nitric oxide synthase, brain	reviewed	-	Nos1	IC50	'='	7500	nM
P35228	BXGT009800	Nitric oxide synthase, inducible	reviewed	-	NOS2	IC50	'='	6600	nM
P29474	BXGT009352	Nitric oxide synthase, endothelial	reviewed	-	NOS3	Ratio	'='	0	-
P35228	BXGT009800	Nitric oxide synthase, inducible	reviewed	-	NOS2	Ratio	'='	0	-
P29474	BXGT009352	Nitric oxide synthase, endothelial	reviewed	-	NOS3	IC50	'='	3500	nM
P35228	BXGT009800	Nitric oxide synthase, inducible	reviewed	-	NOS2	IC50	'='	300	nM
O89049	BXGT005293	Thioredoxin reductase 1, cytoplasmic	reviewed	-	Txnrd1	Potency	-	1412	nM
P33261	BXGT009707	Cytochrome P450 2C19	reviewed	-	CYP2C19	AC50	-	-	-
P29475	BXGT009353	Nitric oxide synthase, brain	reviewed	-	NOS1	IC50	'='	950	nM
P11473	BXGT007709	Vitamin D3 receptor	reviewed	Nuclear receptor	VDR	Potency	-	35481	nM
P35228	BXGT009800	Nitric oxide synthase, inducible	reviewed	-	NOS2	IC50	'='	1	nM
Q03164	BXGT012700	Histone-lysine N-methyltransferase 2A	reviewed	-	KMT2A	Potency	'='	14125	nM
O00255	BXGT003903	Menin	reviewed	-	MEN1	Potency	'='	14125	nM
O08557	BXGT004030	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	reviewed	-	Ddah1	Kcat	'='	5	/min
P29477	BXGT009355	Nitric oxide synthase, inducible	reviewed	-	Nos2	IC50	'='	13000	nM
P35228	BXGT009800	Nitric oxide synthase, inducible	reviewed	-	NOS2	IC50	'='	170000000	nM
P29477	BXGT009355	Nitric oxide synthase, inducible	reviewed	-	Nos2	IC50	'='	2300	nM
P35228	BXGT009800	Nitric oxide synthase, inducible	reviewed	-	NOS2	Selectivity	'='	0	-
P29475	BXGT009353	Nitric oxide synthase, brain	reviewed	-	NOS1	Selectivity	'='	0	-

Foods containing the compound

Foods

BXGF Id	Food Name	Scientific Name	Food Group
BXGF Id	Food Name	Scientific Name	Food Group
BXGF00819	Pulses		Pulses

The compound-realted diseases

Diseases

BXGD Id	Disease Name	CUI Disease Id	Disease Class Name	Number of targets^{?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease}