acompound

Showing entry for Phloretic acid

General Compound Information
BXGC Id	BXGC0000507
Compound Name	Phloretic acid
Structure
Formula	C9H10O3
InchiKey	NMHMNPHRMNGLLB-UHFFFAOYSA-N
SMILES	OC(=O)CCC1=CC=C(O)C=C1
Inchi	InChI=1S/C9H10O3/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-2,4-5,10H,3,6H2,(H,11,12)
IUPAC	3-(4-hydroxyphenyl)propanoic acid
Molecular Weight	166.17
Pubchem Id	10394
Chembl Id	CHEMBL1172560

Targets of Information Source

DrugBank

DB03897

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type
P31012	BXGT009497	Tyrosine phenol-lyase	reviewed	-	tpl	experimental	-
P31013	BXGT009498	Tyrosine phenol-lyase	reviewed	-	tpl	experimental	-
O67636	BXGT005001	Prephenate dehydrogenase	unreviewed	-	tyrA	experimental	-

PDB

HPP

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
P31013	BXGT009498	Tyrosine phenol-lyase	reviewed	tpl	-	1250000	-	-	-
O67636	BXGT005001	Prephenate dehydrogenase	unreviewed	tyrA	-	-	-	-	-
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	reviewed	PIK3CA	Kinase	-	-	-	-
Q14145	BXGT013448	Kelch-like ECH-associated protein 1	reviewed	KEAP1	-	-	-	-	-

Binding DB

n.a

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM

CHEMBL

CHEMBL1172560

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	width="10%">Type	Relation	value	Units
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Type	Relation	value	Units
P26358	BXGT009104	DNA (cytosine-5)-methyltransferase 1	reviewed	Epigenetic regulator	DNMT1	Inhibition	-	-	-
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	reviewed	Kinase	PIK3CA	Inhibition	'<'	25	%
P27986	BXGT009216	Phosphatidylinositol 3-kinase regulatory subunit alpha	reviewed	Kinase	PIK3R1	Inhibition	'<'	25	%
P68400	BXGT011599	Casein kinase II subunit alpha	reviewed	Kinase	CSNK2A1	Delta Tm	'='	3	degrees C
B5U2Z5	BXGT002179	Phenol oxidase	unreviewed	-		Inhibition	-	-	-
B5U2Z5	BXGT002179	Phenol oxidase	unreviewed	-		IC50	'='	84730	nM
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	reviewed	Kinase	PIK3CA	Inhibition	'<'	25	%

Foods containing the compound

Foods

BXGF Id	Food Name	Scientific Name	Food Group
BXGF Id	Food Name	Scientific Name	Food Group
BXGF00016	Peanut	Arachis hypogaea	Nuts
BXGF00105	Apple	Malus pumila	Fruits
BXGF00121	Olive	Olea europaea	Vegetables
BXGF00130	Avocado	Persea americana	Vegetables
BXGF00181	Dandelion	Taraxacum officinale	Herbs and Spices
BXGF00268	Arrowroot	Maranta arundinacea	Vegetables
BXGF00301	Cherimoya	Annona cherimola	Fruits
BXGF00857	Mitracarpus scaber	Mitracarpus scaber	Others
BXGF00866	Diospyros canaliculata	Diospyros canaliculata	Human Edible Plant
BXGF00975	Lindera obtusiloba	Lindera obtusiloba	Medicinal Plant
BXGF00991	Galium verum	Galium verum	Medicinal Plant
BXGF01033	Euclea crispa	Euclea crispa	Medicinal Plant
BXGF01060	Baccharis grandicapitulata	Baccharis grandicapitulata	Others
BXGF01079	Renealmia alpinia	Renealmia alpinia	Human Edible Plant
BXGF01104	Garcinia cambogia	Garcinia cambogia	Medicinal Plant
BXGF01124	Tiliacora racemosa	Tiliacora racemosa	Medicinal Plant
BXGF01185	Aloe vera	Aloe vera	Medicinal Plant
BXGF01207	Morella pensylvanica	Morella pensylvanica	Others
BXGF01252	Petasites laevigatus	Petasites laevigatus	Medicinal Plant
BXGF01276	Delphinium giraldii	Delphinium giraldii	Medicinal Plant
BXGF01337	Stellaria media	Stellaria media	Medicinal Plant
BXGF01404	Sphaeranthus confertifolius	Sphaeranthus confertifolius	Others
BXGF01493	Curcuma aeruginosa	Curcuma aeruginosa	Medicinal Plant
BXGF01556	Ornithoglossum viride	Ornithoglossum viride	Others
BXGF01603	Piper brachystachyum	Piper brachystachyum	Medicinal Plant
BXGF01606	Schizanthus tricolor	Schizanthus tricolor	Others
BXGF01631	Anodendron affine	Anodendron affine	Medicinal Plant
BXGF01668	Taraxacum platycarpum	Taraxacum platycarpum	Medicinal Plant
BXGF01669	Hertia cheirifolia	Hertia cheirifolia	Others
BXGF01688	Tephroseris kirilowii	Tephroseris kirilowii	Medicinal Plant
BXGF01720	Cedrela salvadorensis	Cedrela salvadorensis	Others
BXGF01900	Aloe ferox	Aloe ferox	Medicinal Plant
BXGF01967	Senecio congestus	Senecio congestus	Medicinal Plant
BXGF02028	Artemisia giraldii	Artemisia giraldii	Others
BXGF02076	Calystegia pubescens	Calystegia pubescens	Medicinal Plant
BXGF02124	Papaver pseudocanescens	Papaver pseudocanescens	Others
BXGF02152	Taraxacum borealisinense	Taraxacum borealisinense	Others
BXGF02242	Sideritis dasygnaphala	Sideritis dasygnaphala	Others
BXGF02282	Chenopodium formosanum	Chenopodium formosanum	Others
BXGF02343	Andrographis viscosula	Andrographis viscosula	Medicinal Plant
BXGF02381	Glycyrrhiza inflata	Glycyrrhiza inflata	Medicinal Plant
BXGF02382	Gutierrezia dracunculoides	Gutierrezia dracunculoides	Others
BXGF02423	Psidium acutangulum	Psidium acutangulum	Human Edible Plant
BXGF02440	Beesia calthifolia	Beesia calthifolia	Others
BXGF02483	Bursera kerberi	Bursera kerberi	Others
BXGF02514	Helenium integrifolium	Helenium integrifolium	Others
BXGF02543	Rhododendron mucronulatum	Rhododendron mucronulatum	Medicinal Plant
BXGF02570	Euonymus fortunei	Euonymus fortunei	Medicinal Plant
BXGF02613	Phlomis crinita	Phlomis crinita	Medicinal Plant
BXGF02665	Crotalaria stolzii	Crotalaria stolzii	Others
BXGF02682	Selinum libanotis	Selinum libanotis	Others
BXGF02718	Melampodium leucanthum	Melampodium leucanthum	Others
BXGF02734	Clerodendrum trichotomum	Clerodendrum trichotomum	Medicinal Plant
BXGF02750	Juniperus scopulorum	Juniperus scopulorum	Medicinal Plant
BXGF02785	Clinacanthus nutans	Clinacanthus nutans	Medicinal Plant
BXGF02827	Alstonia angustiloba	Alstonia angustiloba	Others
BXGF02840	Lasianthaea podocephala	Lasianthaea podocephala	Others
BXGF02855	Eucalyptus albens	Eucalyptus albens	Others
BXGF02885	Millettia pinnata	Millettia pinnata	Medicinal Plant
BXGF02903	Lepisorus contortus	Lepisorus contortus	Others
BXGF02908	Pellacalyx axillaris	Pellacalyx axillaris	Others
BXGF02950	Boschniakia rossica	Boschniakia rossica	Medicinal Plant
BXGF03464	Senna spectabilis	Senna spectabilis	Medicinal Plant
BXGF03581	Glycyrrhiza kansuensis	Glycyrrhiza kansuensis	Medicinal Plant
BXGF03587	Aesculus hippocastanum	Aesculus hippocastanum	Medicinal Plant
BXGF03630	Taraxacum coreanum	Taraxacum coreanum	Others
BXGF03779	Picea glauca	Picea glauca	Medicinal Plant
BXGF03817	Coffea liberica var. dewevrei	Coffea liberica var. dewevrei	Medicinal Plant
BXGF04011	Botrychium ternatum	Botrychium ternatum	Medicinal Plant
BXGF04310	Taraxacum mongolicum	Taraxacum mongolicum	Medicinal Plant
BXGF04631	Aloe spicata	Aloe spicata	Medicinal Plant
BXGF04641	Albizia procera	Albizia procera	Medicinal Plant
BXGF04872	Glycyrrhiza glabra	Glycyrrhiza glabra	Medicinal Plant
BXGF04902	Lupinus cosentinii	Lupinus cosentinii	Others
BXGF04908	Diospyros glaucifolia	Diospyros glaucifolia	Others
BXGF04926	Aloe africana	Aloe africana	Medicinal Plant
BXGF04973	Verbascum laxum	Verbascum laxum	Others
BXGF05028	Lampranthus sociorum	Lampranthus sociorum	Others
BXGF05085	Perymenium mendezii	Perymenium mendezii	Others
BXGF05186	Hortonia floribunda	Hortonia floribunda	Others
BXGF05219	Nauclea rhynchophylla	Nauclea rhynchophylla	Others
BXGF05318	Hedysarum gmelini	Hedysarum gmelini	Others
BXGF05436	Rubia tetragona	Rubia tetragona	Others
BXGF05465	Euploca racemosa	Euploca racemosa	Others
BXGF05495	Bursera tonkinensis	Bursera tonkinensis	Medicinal Plant
BXGF05548	Anthocercis albicans	Anthocercis albicans	Others
BXGF05569	Achlys triphylla	Achlys triphylla	Human Edible Plant
BXGF05731	Bulbophyllum protractum	Bulbophyllum protractum	Others
BXGF05747	Tarchonanthus camphoratus	Tarchonanthus camphoratus	Medicinal Plant
BXGF05790	Glycyrrhiza uralensis	Glycyrrhiza uralensis	Medicinal Plant
BXGF05791	Cypripedium calceolus	Cypripedium calceolus	Medicinal Plant
BXGF05858	Ormosia hosiei	Ormosia hosiei	Medicinal Plant
BXGF05902	Lactuca laciniata	Lactuca laciniata	Medicinal Plant
BXGF06250	Licaria chrysophylla	Licaria chrysophylla	Others
BXGF06271	Artemisia pectinata	Artemisia pectinata	Others
BXGF06306	Artemisia porrecta	Artemisia porrecta	Medicinal Plant
BXGF06307	Zephyranthes flava	Zephyranthes flava	Others

The compound-realted diseases

Diseases

BXGD Id	Disease Name	CUI Disease Id	Disease Class Name	Number of targets^{?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease}