Showing entry for Tryptamine


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0000548
Compound NameTryptamine
Structure
FormulaC10H12N2
InchiKeyAPJYDQYYACXCRM-UHFFFAOYSA-N
SMILESNCCC1=CNC2=CC=CC=C12
InchiInChI=1S/C10H12N2/c11-6-5-8-7-12-10-4-2-1-3-9(8)10/h1-4,7,12H,5-6,11H2
IUPAC2-(1H-indol-3-yl)ethan-1-amine
Molecular Weight160.22
Pubchem Id1150
Chembl IdCHEMBL6640
Targets of Information Source
DrugBank DB08653
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
P84887 BXGT012067 Aralkylamine dehydrogenase light chain reviewed - aauA experimental -
P84888 BXGT012068 Aralkylamine dehydrogenase heavy chain reviewed - aauB experimental -
PDB TSS
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P84887 BXGT012067 Aralkylamine dehydrogenase light chain reviewed aauA - - - - -
P68175 BXGT011585 Strictosidine synthase reviewed STR1 - - - - -
P84888 BXGT012068 Aralkylamine dehydrogenase heavy chain reviewed aauB - - - - -
Q9BIH3 BXGT020097 D7-related 4 protein unreviewed d7r4 - - - 53 -
P00760 BXGT005644 Cationic trypsin reviewed - - - - -
Q86PT9 BXGT017596 Biogenic amine-binding protein unreviewed - - - - -
C6FX51 BXGT002540 3-methyl-2-indolic acid synthase unreviewed nosL - - - - -
Q6ZJK7 BXGT024646 Tryptophan decarboxylase 1 reviewed TDC1 - - - - -
Q8KHZ8 BXGT018425 Flavin-dependent tryptophan halogenase RebH reviewed rebH - - - - -
Binding DB 50024210
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT009274 5-hydroxytryptamine receptor 1E reviewed G-protein coupled receptor HTR1E 2559 - - -
reviewed BXGT009238 5-hydroxytryptamine receptor 1B reviewed G-protein coupled receptor HTR1B 86 - - -
reviewed BXGT009237 5-hydroxytryptamine receptor 1D reviewed G-protein coupled receptor HTR1D 521 - - -
reviewed BXGT008059 5-hydroxytryptamine receptor 2A reviewed Htr2a 11 - - -
reviewed BXGT008472 5-hydroxytryptamine receptor 1A reviewed Htr1a 3715.35 - - -
reviewed BXGT008472 5-hydroxytryptamine receptor 1A reviewed Htr1a >10000 - - -
reviewed BXGT008059 5-hydroxytryptamine receptor 2A reviewed Htr2a 2932 - - -
reviewed BXGT008059 5-hydroxytryptamine receptor 2A reviewed Htr2a 1682 - - -
reviewed BXGT008059 5-hydroxytryptamine receptor 2A reviewed Htr2a 538 - - -
reviewed BXGT026170 5-hydroxytryptamine receptor 7 reviewed HTR7 64.56 - - -
reviewed BXGT026170 5-hydroxytryptamine receptor 7 reviewed HTR7 19.05 - - -
reviewed BXGT009532 5-hydroxytryptamine receptor 6 reviewed Htr6 438 - - -
reviewed BXGT006837 5-hydroxytryptamine receptor 1A reviewed G-protein coupled receptor HTR1A 104.71 - - -
reviewed BXGT009238 5-hydroxytryptamine receptor 1B reviewed G-protein coupled receptor HTR1B 524.8 - - -
reviewed BXGT009237 5-hydroxytryptamine receptor 1D reviewed G-protein coupled receptor HTR1D 85.11 - - -
reviewed BXGT007730 5-hydroxytryptamine receptor 1D reviewed HTR1D 346.73 - - -
reviewed BXGT008059 5-hydroxytryptamine receptor 2A reviewed Htr2a 25.11 - - -
reviewed BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A 89.12 - - -
reviewed BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A 3162.27 - - -
reviewed BXGT008059 5-hydroxytryptamine receptor 2A reviewed Htr2a 3890.45 - - -
reviewed BXGT012637 5-hydroxytryptamine receptor 2B reviewed Htr2b 199.52 - - -
reviewed BXGT009493 5-hydroxytryptamine receptor 2B reviewed Htr2b 199.52 - - -
reviewed BXGT009493 5-hydroxytryptamine receptor 2B reviewed Htr2b 112.2 - - -
reviewed BXGT009621 5-hydroxytryptamine receptor 7 reviewed Htr7 33.11 - - -
reviewed BXGT009777 5-hydroxytryptamine receptor 7 reviewed G-protein coupled receptor HTR7 147.91 - - -
reviewed BXGT009621 5-hydroxytryptamine receptor 7 reviewed Htr7 16.21 - - -
reviewed BXGT026171 5-hydroxytryptamine receptor 4 reviewed Htr4 >10000 - - -
reviewed BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 438 - - -
reviewed BXGT009777 5-hydroxytryptamine receptor 7 reviewed G-protein coupled receptor HTR7 149 - - -
reviewed BXGT009483 5-hydroxytryptamine receptor 1F reviewed G-protein coupled receptor HTR1F 2409 - - -
reviewed BXGT009621 5-hydroxytryptamine receptor 7 reviewed Htr7 32.8 - - -
reviewed BXGT009621 5-hydroxytryptamine receptor 7 reviewed Htr7 16.4 - - -
reviewed BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C 3000 - - -
reviewed BXGT010774 5-hydroxytryptamine receptor 2A reviewed HTR2A 3394 - - -
reviewed BXGT008059 5-hydroxytryptamine receptor 2A reviewed Htr2a >10000 - - -
reviewed BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B 73.2 - - -
reviewed BXGT009493 5-hydroxytryptamine receptor 2B reviewed Htr2b 113 - - -
reviewed BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A 588.84 - - -
reviewed BXGT008059 5-hydroxytryptamine receptor 2A reviewed Htr2a 416.86 - - -
reviewed BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B 25.11 - - -
reviewed BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C 295.12 - - -
reviewed BXGT006838 5-hydroxytryptamine receptor 2C reviewed Htr2c 56.23 - - -
reviewed BXGT009532 5-hydroxytryptamine receptor 6 reviewed Htr6 158.48 - - -
reviewed BXGT009532 5-hydroxytryptamine receptor 6 reviewed Htr6 1479.1 - - -
reviewed BXGT006838 5-hydroxytryptamine receptor 2C reviewed Htr2c 62 - - -
reviewed BXGT006838 5-hydroxytryptamine receptor 2C reviewed Htr2c 772 - - -
reviewed BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A 257.04 - - -
reviewed BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B 29.51 - - -
reviewed BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C 45.71 - - -
reviewed BXGT019728 Trace amine-associated receptor 1 reviewed G-protein coupled receptor TAAR1 1084 - - -
reviewed BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A 218.78 - - -
reviewed BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B 102.33 - - -
reviewed BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C 2344.23 - - -
reviewed BXGT009237 5-hydroxytryptamine receptor 1D reviewed G-protein coupled receptor HTR1D 61 - - -
reviewed BXGT009238 5-hydroxytryptamine receptor 1B reviewed G-protein coupled receptor HTR1B 36 - - -
reviewed BXGT009237 5-hydroxytryptamine receptor 1D reviewed G-protein coupled receptor HTR1D 23 - - -
reviewed BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 180 - - -
reviewed BXGT010368 Cathepsin K reviewed Enzyme CTSK - 15000 - -
reviewed BXGT009565 Sodium-dependent serotonin transporter reviewed Slc6a4 - - - 33
reviewed BXGT008936 Sodium-dependent dopamine transporter reviewed Slc6a3 - - - 164
reviewed BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A - - - 7.4
reviewed BXGT007716 Cytochrome P450 2A6 reviewed CYP2A6 1700 - - -
reviewed BXGT013658 Cytochrome P450 2A13 reviewed CYP2A13 16000 - - -
reviewed BXGT007716 Cytochrome P450 2A6 reviewed CYP2A6 - - 2300 -
reviewed BXGT013658 Cytochrome P450 2A13 reviewed CYP2A13 - - 5200 -
reviewed BXGT008818 Alpha-2A adrenergic receptor reviewed Adra2a 19000 - - -
reviewed BXGT008059 5-hydroxytryptamine receptor 2A reviewed Htr2a 2895 - - -
reviewed BXGT008059 5-hydroxytryptamine receptor 2A reviewed Htr2a 50 - - -
reviewed BXGT008472 5-hydroxytryptamine receptor 1A reviewed Htr1a 170 - - -
reviewed BXGT009272 5-hydroxytryptamine receptor 1B reviewed Htr1b 10200 - - -
reviewed BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C 50 - - -
reviewed BXGT009493 5-hydroxytryptamine receptor 2B reviewed Htr2b - - 537.03 -
reviewed BXGT006333 Myeloperoxidase reviewed Enzyme MPO - 770 - -
CHEMBL CHEMBL6640
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P28222 BXGT009238 5-hydroxytryptamine receptor 1B reviewed G-protein coupled receptor HTR1B Ki '=' 36 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 39810 nM
P28221 BXGT009237 5-hydroxytryptamine receptor 1D reviewed G-protein coupled receptor HTR1D p[A50] '=' 6 -
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 101 %
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 Ki '=' 180 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 29092 nM
P14842 BXGT008059 5-hydroxytryptamine receptor 2A reviewed - Htr2a Ki '=' 50 nM
P08909 BXGT006838 5-hydroxytryptamine receptor 2C reviewed - Htr2c Ki '=' 50 nM
P30994 BXGT009493 5-hydroxytryptamine receptor 2B reviewed - Htr2b Ki '=' 50 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 AC50 '=' 31622 nM
P14902 BXGT008065 Indoleamine 2,3-dioxygenase 1 reviewed - IDO1 Activity - - -
P19838 BXGT008526 Nuclear factor NF-kappa-B p105 subunit reviewed Transcription factor NFKB1 Potency '=' 12589 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 6513 nM
O75164 BXGT005104 Lysine-specific demethylase 4A reviewed - KDM4A Potency - 50118 nM
Q4WAW7 BXGT014911 Tryprostatin B synthase reviewed - ftmPT1 Activity '<=' 1 %
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 AC50 '=' 3162 nM
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a Ki '=' 169 nM
P22909 BXGT008818 Alpha-2A adrenergic receptor reviewed - Adra2a Ki '=' 19000 nM
P19328 BXGT008473 Alpha-2B adrenergic receptor reviewed - Adra2b Ki '=' 19000 nM
P22086 BXGT008728 Alpha-2C adrenergic receptor reviewed - Adra2c Ki '=' 19000 nM
P28221 BXGT009237 5-hydroxytryptamine receptor 1D reviewed G-protein coupled receptor HTR1D Ki '=' 61 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Potency '=' 31622 nM
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Potency - 1299 nM
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 AC50 - - -
P28221 BXGT009237 5-hydroxytryptamine receptor 1D reviewed G-protein coupled receptor HTR1D Selectivity '=' 1 -
P30994 BXGT009493 5-hydroxytryptamine receptor 2B reviewed - Htr2b Kd '=' 537 nM
P11509 BXGT007716 Cytochrome P450 2A6 reviewed - CYP2A6 Activity - - -
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A p[A50] '=' 6 -
P28221 BXGT009237 5-hydroxytryptamine receptor 1D reviewed G-protein coupled receptor HTR1D Intrinsic activity '=' 0 -
P18417 BXGT008401 Strictosidine synthase reviewed - STR1 Km '=' 7400 nM
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a Ki '=' 170 nM
P14842 BXGT008059 5-hydroxytryptamine receptor 2A reviewed - Htr2a Ki '=' 2895 nM
P08909 BXGT006838 5-hydroxytryptamine receptor 2C reviewed - Htr2c Ki '=' 2895 nM
P30994 BXGT009493 5-hydroxytryptamine receptor 2B reviewed - Htr2b Ki '=' 2895 nM
P28221 BXGT009237 5-hydroxytryptamine receptor 1D reviewed G-protein coupled receptor HTR1D Ki '=' 23 nM
P28564 BXGT009272 5-hydroxytryptamine receptor 1B reviewed - Htr1b Ki '=' 10200 nM
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C Ki '=' 50 nM
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 Ki '=' 70 nM
P14902 BXGT008065 Indoleamine 2,3-dioxygenase 1 reviewed - IDO1 Ki '=' 160000 nM
Q9NR56 BXGT021179 Muscleblind-like protein 1 reviewed Nucleic acid binding MBNL1 Potency - 141 nM
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A Emax '=' 104 %
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 AC50 - - -
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 32629 nM
Q9WTR4 BXGT021930 Transporter unreviewed - Slc6a2 EC50 '=' 716 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 10322 nM
O15648 BXGT004185 ATP-dependent 6-phosphofructokinase reviewed - pfk Potency - 7568 nM
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Potency - 25929 nM
P04608 BXGT006236 Protein Tat reviewed - tat IC50 - 11753 nM
P05164 BXGT006333 Myeloperoxidase reviewed Enzyme MPO IC50 '=' 770 nM
P11509 BXGT007716 Cytochrome P450 2A6 reviewed - CYP2A6 Kd '=' 2300 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 AC50 - - -
Q16696 BXGT013658 Cytochrome P450 2A13 reviewed - CYP2A13 Kd '=' 5200 nM
Q4WAW7 BXGT014911 Tryprostatin B synthase reviewed - ftmPT1 Activity '<=' 5 %
P15289 BXGT008102 Arylsulfatase A reviewed Enzyme ARSA Potency - 601 nM
P11509 BXGT007716 Cytochrome P450 2A6 reviewed - CYP2A6 Ki '=' 1700 nM
Q16696 BXGT013658 Cytochrome P450 2A13 reviewed - CYP2A13 Ki '=' 16000 nM
P14902 BXGT008065 Indoleamine 2,3-dioxygenase 1 reviewed - IDO1 Activity '=' 0 %
P43235 BXGT010368 Cathepsin K reviewed Enzyme CTSK IC50 '=' 15000 nM
P31652 BXGT009565 Sodium-dependent serotonin transporter reviewed - Slc6a4 EC50 '=' 32 nM
Q923Y9 BXGT019346 Trace amine-associated receptor 1 reviewed - Taar1 EC50 '=' 310 nM
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 104 %
P23977 BXGT008936 Sodium-dependent dopamine transporter reviewed - Slc6a3 EC50 '=' 164 nM
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A EC50 '=' 7 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00052 Watermelon Citrullus lanatus Gourds
BXGF00065 Cucumber Cucumis sativus Gourds
BXGF00088 Barley Hordeum vulgare Cereals and cereal products
BXGF00098 Lentils Lens culinaris Pulses
BXGF00147 European plum Prunus domestica Fruits
BXGF00151 Pomegranate Punica granatum Fruits
BXGF00171 Garden tomato Solanum lycopersicum Vegetables
BXGF00173 Garden tomato (var.) Solanum lycopersicum var. lycopersicum Vegetables
BXGF00174 Eggplant Solanum melongena Vegetables
BXGF00175 Potato Solanum tuberosum Vegetables
BXGF00182 Cocoa bean Theobroma cacao Cocoa and cocoa products
BXGF00205 Corn Zea mays Cereals and cereal products
BXGF00805 Mushrooms Vegetables
BXGF00819 Pulses Pulses
BXGF00862 Phebalium ozothamnoides Phebalium ozothamnoides Others
BXGF00977 Vitex megapotamica Vitex megapotamica Human Edible Plant
BXGF01266 Dysoxylum lenticellatum Dysoxylum lenticellatum Others
BXGF01284 Saururus cernuus Saururus cernuus Medicinal Plant
BXGF01343 Strychnos fendleri Strychnos fendleri Others
BXGF01466 Halimeda macroloba Halimeda macroloba Others
BXGF01510 Cabucala madagascariensis Cabucala madagascariensis Others
BXGF02527 Nicotiana tabacum Nicotiana tabacum Medicinal Plant
BXGF02723 Hesperocyparis macrocarpa Hesperocyparis macrocarpa Others
BXGF02848 Buxus sempervirens Buxus sempervirens Medicinal Plant
BXGF03270 Aruncus dioicus Aruncus dioicus Medicinal Plant
BXGF03442 Rhaponticum carthamoides Rhaponticum carthamoides Medicinal Plant
BXGF03924 Kochia trichophylla Kochia trichophylla Others
BXGF04049 Symplocos lancifolia Symplocos lancifolia Others
BXGF04191 Vicia villosa Vicia villosa Medicinal Plant
BXGF04787 Valeriana jatamansi Valeriana jatamansi Medicinal Plant
BXGF04830 Artemisia oranensis Artemisia oranensis Others
BXGF05193 Piper futokadsura Piper futokadsura Others
BXGF05692 Potentilla multifida Potentilla multifida Medicinal Plant
BXGF05859 Haplopappus venetus Haplopappus venetus Others
BXGF05925 Centaurea amara Centaurea amara Others
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease