Showing entry for 7,4'-Dihydroxyflavone


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0001023
Compound Name7,4'-Dihydroxyflavone
Structure
FormulaC15H10O4
InchiKeyLCAWNFIFMLXZPQ-UHFFFAOYSA-N
SMILESOC1=CC=C(C=C1)C1=CC(=O)C2=C(O1)C=C(O)C=C2
InchiInChI=1S/C15H10O4/c16-10-3-1-9(2-4-10)14-8-13(18)12-6-5-11(17)7-15(12)19-14/h1-8,16-17H
IUPAC7-hydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
Molecular Weight254.24
Pubchem Id5282073
Chembl IdCHEMBL294878
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 50077323
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT006500 Beta-glucuronidase reviewed Gusb - 13700 - -
reviewed BXGT005616 Lysozyme C-1 reviewed Lyz1 - >30000 - -
reviewed BXGT008197 Aldo-keto reductase family 1 member B1 reviewed AKR1B1 - 13630 - -
reviewed BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK - 2 - -
reviewed BXGT013665 Glutaminyl-peptide cyclotransferase reviewed Enzyme QPCT - 45200 - -
reviewed BXGT022265 Sialidase-2 reviewed Enzyme NEU2 - 470000 - -
reviewed BXGT007717 Aromatase reviewed Enzyme CYP19A1 - 2 - -
CHEMBL CHEMBL294878
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P06760 BXGT006500 Beta-glucuronidase reviewed - Gusb IC50 '=' 13700 nM
P02791 BXGT005965 Ferritin light chain reviewed - FTL Potency '=' 35481 nM
Q03181 BXGT012701 Peroxisome proliferator-activated receptor delta reviewed Nuclear receptor PPARD FC '=' 5 -
Q16637 BXGT013646 Survival motor neuron protein reviewed Epigenetic regulator SMN1 Potency '=' 35481 nM
P05164 BXGT006333 Myeloperoxidase reviewed Enzyme MPO IC50 '=' 5790 nM
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 Ke '=' 1610 nM
Q07869 BXGT012945 Peroxisome proliferator-activated receptor alpha reviewed Nuclear receptor PPARA FC '=' 1 -
P16116 BXGT008197 Aldo-keto reductase family 1 member B1 reviewed - AKR1B1 IC50 '=' 13630 nM
P18031 BXGT008369 Tyrosine-protein phosphatase non-receptor type 1 reviewed - PTPN1 Inhibition '<' 50 %
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 Ke '=' 480 nM
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 Ke '=' 2090 nM
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma reviewed Nuclear receptor PPARG FC '=' 5 -
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 10000 nM
P11511 BXGT007717 Aromatase reviewed Enzyme CYP19A1 IC50 '=' 2 nM
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK IC50 '=' 200 ug.mL-1
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma reviewed Nuclear receptor PPARG FC '=' 1 -
Q9Y3R4 BXGT022265 Sialidase-2 reviewed Enzyme NEU2 IC50 '=' 470000 nM
P27338 BXGT009172 Amine oxidase [flavin-containing] B reviewed - MAOB IC50 '=' 30 nM
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA IC50 '=' 30 nM
Q07869 BXGT012945 Peroxisome proliferator-activated receptor alpha reviewed Nuclear receptor PPARA FC '=' 2 -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 29092 nM
P00697 BXGT005616 Lysozyme C-1 reviewed - Lyz1 IC50 '>' 30000 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 FC '=' 1 -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 7943 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 794 nM
P05091 BXGT006312 Aldehyde dehydrogenase, mitochondrial reviewed Enzyme ALDH2 NI - - -
Q16769 BXGT013665 Glutaminyl-peptide cyclotransferase reviewed Enzyme QPCT Inhibition '=' 71 %
Q16769 BXGT013665 Glutaminyl-peptide cyclotransferase reviewed Enzyme QPCT IC50 '=' 45200 nM
P09917 BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 Inhibition '<' 50 %
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma reviewed Nuclear receptor PPARG Activity - - -
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 8912 nM
Q07869 BXGT012945 Peroxisome proliferator-activated receptor alpha reviewed Nuclear receptor PPARA Activity - - -
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Potency '=' 10000 nM
Q15118 BXGT013540 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial reviewed Kinase PDK1 Inhibition '=' 12 %
P06280 BXGT006433 Alpha-galactosidase A reviewed - GLA Potency - 39810 nM
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 7943 nM
Q03181 BXGT012701 Peroxisome proliferator-activated receptor delta reviewed Nuclear receptor PPARD FC '=' 3 -
P18031 BXGT008369 Tyrosine-protein phosphatase non-receptor type 1 reviewed - PTPN1 Inhibition '=' 55 %
Q15118 BXGT013540 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial reviewed Kinase PDK1 Inhibition - - -
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00186 Fenugreek Trigonella foenum-graecum Herbs and Spices
BXGF00197 Broad bean Vicia faba Pulses
BXGF00199 Gram bean Vigna mungo Pulses
BXGF00264 Alfalfa Medicago sativa Herbs and Spices
BXGF00503 Rowal Pangium edule Herbs and Spices
BXGF00857 Mitracarpus scaber Mitracarpus scaber Others
BXGF00903 Crotalaria assamica Crotalaria assamica Medicinal Plant
BXGF01051 Callicarpa japonica Callicarpa japonica Medicinal Plant
BXGF01061 Avrainvillea longicaulis Avrainvillea longicaulis Others
BXGF01385 Glycyrrhiza yunnanensis Glycyrrhiza yunnanensis Medicinal Plant
BXGF01599 Helichrysum cephaloideum Helichrysum cephaloideum Medicinal Plant
BXGF01684 Hemionitis japonica Hemionitis japonica Others
BXGF01793 Sedum obtuso-lineare Sedum obtuso-lineare Others
BXGF01890 Trollius chinensis Trollius chinensis Medicinal Plant
BXGF02053 Hypericum balearicum Hypericum balearicum Others
BXGF02131 Glycyrrhiza Glycyrrhiza Medicinal Plant
BXGF02199 Bryum argenteum Bryum argenteum Medicinal Plant
BXGF02341 Euphorbia amygdaloides Euphorbia amygdaloides Medicinal Plant
BXGF02380 Entada phaseoloides Entada phaseoloides Medicinal Plant
BXGF02381 Glycyrrhiza inflata Glycyrrhiza inflata Medicinal Plant
BXGF02421 Hesperis matronalis Hesperis matronalis Medicinal Plant
BXGF02449 Jatropha macrorhiza Jatropha macrorhiza Others
BXGF02540 Jackiella javanica Jackiella javanica Medicinal Plant
BXGF02587 Rhus vulgaris Rhus vulgaris Human Edible Plant
BXGF02610 Cladrastis platycarpa Cladrastis platycarpa Others
BXGF02646 Eremanthus seidelii Eremanthus seidelii Others
BXGF02732 Senecio adenophyllus Senecio adenophyllus Others
BXGF02768 Lilium umbellatum Lilium umbellatum Others
BXGF02784 Artemisia rehan Artemisia rehan Others
BXGF02807 Elephantopus hirtiflorus Elephantopus hirtiflorus Others
BXGF02828 Nematolepis phebalioides Nematolepis phebalioides Others
BXGF02839 Solidago flexicaulis Solidago flexicaulis Human Edible Plant
BXGF02854 Ligularia cymbulifera Ligularia cymbulifera Others
BXGF02877 Coprosma areolata Coprosma areolata Medicinal Plant
BXGF02907 Oreopteris quelpaertensis Oreopteris quelpaertensis Others
BXGF02948 Viguiera linearis Viguiera linearis Others
BXGF03313 Magnolia montana Magnolia montana Medicinal Plant
BXGF03504 Sterculia foetida Sterculia foetida Medicinal Plant
BXGF04255 Gmelina asiatica Gmelina asiatica Medicinal Plant
BXGF04312 Sophora viciifolia Sophora viciifolia Medicinal Plant
BXGF04659 Phyllanthus emblica Phyllanthus emblica Medicinal Plant
BXGF04872 Glycyrrhiza glabra Glycyrrhiza glabra Medicinal Plant
BXGF05285 Aglaia formosana Aglaia formosana Others
BXGF05369 Daemonorops draco Daemonorops draco Medicinal Plant
BXGF05476 Broussonetia papyrifera Broussonetia papyrifera Medicinal Plant
BXGF05790 Glycyrrhiza uralensis Glycyrrhiza uralensis Medicinal Plant
BXGF06266 Crotalaria pallida Crotalaria pallida Medicinal Plant
BXGF06311 Crinum asiaticum Crinum asiaticum Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease