Showing entry for 3-(1H-Benzimidazol-2-Yl)-7-(Diethylamino)Chromen-2-One


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0024428
Compound Name3-(1H-Benzimidazol-2-Yl)-7-(Diethylamino)Chromen-2-One
Structure
FormulaC20H19N3O2
InchiKeyGOLORTLGFDVFDW-UHFFFAOYSA-N
SMILESCCN(c1ccc2c(c1)oc(=O)c(c2)c1nc2c([nH]1)cccc2)CC
InchiInChI=1S/C20H19N3O2/c1-3-23(4-2)14-10-9-13-11-15(20(24)25-18(13)12-14)19-21-16-7-5-6-8-17(16)22-19/h5-12H,3-4H2,1-2H3,(H,21,22)
IUPAC3-(1H-benzimidazol-2-yl)-7-(diethylamino)chromen-2-one
Molecular Weight333.15
Pubchem Id94381
Chembl IdCHEMBL374632
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 37601
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT012815 Focal adhesion kinase 1 reviewed Kinase PTK2 - 7598 - -
reviewed BXGT013459 Protein-tyrosine kinase 2-beta reviewed Kinase PTK2B - 2324 - -
reviewed BXGT012285 dTDP-4-dehydrorhamnose 3,5-epimerase reviewed rmlC - 7352 - -
reviewed BXGT021373 Protein LANA1 reviewed LANA1 - - - >75000
reviewed BXGT005358 Voltage-dependent T-type calcium channel subunit alpha-1H reviewed Ion channel CACNA1H - - - 434
CHEMBL CHEMBL374632
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P15917 BXGT008169 Lethal factor reviewed - lef Potency '=' 1584 nM
P06746 BXGT006496 DNA polymerase beta reviewed Enzyme POLB Potency '=' 100000 nM
O00167 BXGT003887 Eyes absent homolog 2 reviewed - EYA2 Potency - 2511 nM
Q5J463 BXGT015429 Beta-lactamase unreviewed - tem-1 IC50 '=' 709 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 1000 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 1000 nM
O94925 BXGT005342 Glutaminase kidney isoform, mitochondrial reviewed Enzyme GLS Potency - 12589 nM
Q13951 BXGT013407 Core-binding factor subunit beta reviewed - CBFB Potency - 1258 nM
Q01196 BXGT012575 Runt-related transcription factor 1 reviewed Transcription factor RUNX1 Potency - 1258 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 9959 nM
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 1122 nM
P08659 BXGT006805 Luciferin 4-monooxygenase reviewed - Potency '=' 39 nM
P55210 BXGT011110 Caspase-7 reviewed Enzyme CASP7 Potency '=' 158 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 3965 nM
Q9UNA4 BXGT021785 DNA polymerase iota reviewed - POLI Potency - 100000 nM
P08659 BXGT006805 Luciferin 4-monooxygenase reviewed - EC50 '<' 200 nM
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency '=' 316 nM
Q14289 BXGT013459 Protein-tyrosine kinase 2-beta reviewed Kinase PTK2B IC50 '=' 2324 nM
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 Potency '=' 158 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 1584 nM
Q94696 BXGT019553 Luciferase unreviewed - luc Potency '=' 10000 nM
Q13315 BXGT013339 Serine-protein kinase ATM reviewed Kinase ATM Potency - 4626 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 9200 nM
Q13526 BXGT013369 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 reviewed - PIN1 Potency - 15101 nM
P84022 BXGT012027 Mothers against decapentaplegic homolog 3 reviewed Transcription factor SMAD3 Potency - 707 nM
O75604 BXGT005139 Ubiquitin carboxyl-terminal hydrolase 2 reviewed Enzyme USP2 Potency '=' 891 nM
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 183 nM
O75604 BXGT005139 Ubiquitin carboxyl-terminal hydrolase 2 reviewed Enzyme USP2 Potency '=' 199 nM
O15118 BXGT004127 NPC intracellular cholesterol transporter 1 reviewed Transporter NPC1 Potency '=' 281 nM
P38398 BXGT010037 Breast cancer type 1 susceptibility protein reviewed Enzyme BRCA1 Potency '=' 125 nM
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency '=' 398 nM
Q8WZA2 BXGT019025 Rap guanine nucleotide exchange factor 4 reviewed Enzyme modulator RAPGEF4 Potency - 89125 nM
P08659 BXGT006805 Luciferin 4-monooxygenase reviewed - IC50 '=' 380 nM
P08659 BXGT006805 Luciferin 4-monooxygenase reviewed - IC50 '=' 120 nM
P08659 BXGT006805 Luciferin 4-monooxygenase reviewed - IC50 '=' 400 nM
Q13315 BXGT013339 Serine-protein kinase ATM reviewed Kinase ATM Potency '=' 8912 nM
Q6W5P4 BXGT016588 Neuropeptide S receptor reviewed - NPSR1 Potency '=' 12589 nM
P08659 BXGT006805 Luciferin 4-monooxygenase reviewed - Inhibition '=' 100 %
P08659 BXGT006805 Luciferin 4-monooxygenase reviewed - IC50 '=' 240 nM
P08659 BXGT006805 Luciferin 4-monooxygenase reviewed - IC50 '=' 14000 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 446 nM
Q99700 BXGT019949 Ataxin-2 reviewed Nucleic acid binding ATXN2 Potency - 794 nM
Q9HC16 BXGT020525 DNA dC->dU-editing enzyme APOBEC-3G reviewed Enzyme APOBEC3G Potency - 3548 nM
Q932Y6 BXGT019466 Beta-lactamase unreviewed - bla(tem-2) IC50 '=' 2728 nM
O95149 BXGT005350 Snurportin-1 reviewed - SNUPN Potency - 3981 nM
Q14974 BXGT013516 Importin subunit beta-1 reviewed Transporter KPNB1 Potency - 3981 nM
P62826 BXGT011463 GTP-binding nuclear protein Ran reviewed Enzyme modulator RAN Potency - 3981 nM
P83916 BXGT012025 Chromobox protein homolog 1 reviewed Epigenetic regulator CBX1 Potency - 12589 nM
P42858 BXGT010341 Huntingtin reviewed - HTT Potency '=' 316 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 11220 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 11220 nM
Q13315 BXGT013339 Serine-protein kinase ATM reviewed Kinase ATM Potency - 29192 nM
P02791 BXGT005965 Ferritin light chain reviewed - FTL Potency '=' 25118 nM
P68871 BXGT011615 Hemoglobin subunit beta reviewed - HBB Potency '=' 794 nM
P51151 BXGT010837 Ras-related protein Rab-9A reviewed - RAB9A Potency '=' 100 nM
P08659 BXGT006805 Luciferin 4-monooxygenase reviewed - Potency - 75 nM
O95398 BXGT005378 Rap guanine nucleotide exchange factor 3 reviewed Enzyme modulator RAPGEF3 Potency - 125892 nM
Q9Y253 BXGT022216 DNA polymerase eta reviewed - POLH Potency - 7079 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 2818 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 5173 nM
O95180 BXGT005358 Voltage-dependent T-type calcium channel subunit alpha-1H reviewed Ion channel CACNA1H EC50 - 434 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 4109 nM
Q99816 BXGT019966 Tumor susceptibility gene 101 protein reviewed Enzyme TSG101 Potency - 15848 nM
Q79MP6 BXGT016893 Beta-lactamase unreviewed - blaIMP-1 IC50 '=' 3241 nM
O95149 BXGT005350 Snurportin-1 reviewed - SNUPN Potency - 3162 nM
Q14974 BXGT013516 Importin subunit beta-1 reviewed Transporter KPNB1 Potency - 3162 nM
P01215 BXGT005743 Glycoprotein hormones alpha chain reviewed - CGA Potency - 2238 nM
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 1258 nM
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 145 nM
Q9NR56 BXGT021179 Muscleblind-like protein 1 reviewed Nucleic acid binding MBNL1 Potency - 7079 nM
O95398 BXGT005378 Rap guanine nucleotide exchange factor 3 reviewed Enzyme modulator RAPGEF3 Potency - 2818 nM
P53350 BXGT010984 Serine/threonine-protein kinase PLK1 reviewed Kinase PLK1 Potency - 26679 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00050 Chinese cinnamon Cinnamomum aromaticum Herbs and Spices
BXGF01065 Artemisia capillaris Artemisia capillaris Medicinal Plant
BXGF01442 Torilis japonica Torilis japonica Medicinal Plant
BXGF02030 Angelica decursiva Angelica decursiva Medicinal Plant
BXGF02065 Cnidium monnieri Cnidium monnieri Medicinal Plant
BXGF02381 Glycyrrhiza inflata Glycyrrhiza inflata Medicinal Plant
BXGF03735 Hansenia weberbaueriana Hansenia weberbaueriana Others
BXGF03865 Hansenia forbesii Hansenia forbesii Others
BXGF03888 Angelica dahurica Angelica dahurica Medicinal Plant
BXGF04872 Glycyrrhiza glabra Glycyrrhiza glabra Medicinal Plant
BXGF04900 Ostericum grosseserratum Ostericum grosseserratum Human Edible Plant
BXGF05260 Peucedanum praeruptorum Peucedanum praeruptorum Medicinal Plant
BXGF05790 Glycyrrhiza uralensis Glycyrrhiza uralensis Medicinal Plant
BXGF06128 Cnidium monieri Cnidium monieri Others
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease