Showing entry for Cgmp


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0036634
Compound NameCgmp
Structure
FormulaC10H12N5O7P
InchiKeyZOOGRGPOEVQQDX-UUOKFMHZSA-N
SMILESO[C@@H]1[C@@H]2OP(=O)(O)OC[C@H]2O[C@H]1n1cnc2c1[nH]c(=N)nc2O
InchiInChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/t3-,5-,6-,9-/m1/s1
IUPAC9-[(4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-2-amino-3H-purin-6-one
Molecular Weight345.05
Pubchem Id135398570
Chembl IdCHEMBL395336
Targets of Information Source
DrugBank DB02315
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
O00408 BXGT003916 cGMP-dependent 3',5'-cyclic phosphodiesterase reviewed - PDE2A experimental -
Q9UL51 BXGT021754 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 reviewed Ion channel HCN2 experimental -
P10644 BXGT007597 cAMP-dependent protein kinase type I-alpha regulatory subunit reviewed - PRKAR1A experimental -
PDB PCG
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P52175 BXGT010920 Nucleoside diphosphate kinase A 2 reviewed NME1-2 - - - - -
P52174 BXGT022681 Nucleoside diphosphate kinase A 1 reviewed NME1-1 - - - - -
Q922S4 BXGT019339 cGMP-dependent 3',5'-cyclic phosphodiesterase reviewed Pde2a - - - - -
O88703 BXGT005281 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 reviewed Hcn2 - - - - -
P00514 BXGT005565 cAMP-dependent protein kinase type I-alpha regulatory subunit reviewed PRKAR1A - - - - -
P39779 BXGT010137 GTP-sensing transcriptional pleiotropic repressor CodY reviewed codY - - - - -
Q8CG03 BXGT022689 cGMP-specific 3',5'-cyclic phosphodiesterase reviewed Pde5a - - - - -
Q9Y233 BXGT022210 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A reviewed PDE10A - - - - -
Q98GN8 BXGT019897 Cyclic nucleotide-gated potassium channel mll3241 reviewed mll3241 - - - - -
P52731 BXGT010947 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' reviewed PDE6C - - - - -
O76083 BXGT005176 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A reviewed PDE9A - - - - -
Q13976 BXGT013409 cGMP-dependent protein kinase 1 reviewed PRKG1 Kinase - - - -
E0RR11 BXGT003049 Uncharacterized protein unreviewed STHERM_c06300 - - - - -
Q9Y3Q4 BXGT022264 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 reviewed HCN4 Ion channel - - - -
Q13976 BXGT013409 cGMP-dependent protein kinase 1 reviewed PRKG1 Kinase - - 12 -
Q98GN8 BXGT019897 Cyclic nucleotide-gated potassium channel mll3241 reviewed mll3241 - - - 336 -
C3SQJ7 BXGT002448 CRP transcriptional dual regulator unreviewed crp - - - 25600 -
Q8I719 BXGT018234 cGMP-dependent protein kinase unreviewed PF3D7_1436600 - - - - -
Q13237 BXGT013331 cGMP-dependent protein kinase 2 reviewed PRKG2 Kinase - - 31 -
Q13237 BXGT013331 cGMP-dependent protein kinase 2 reviewed PRKG2 Kinase - - 43.8 -
Q03611 BXGT012730 Cyclic nucleotide-gated cation channel reviewed tax-4 - - - - -
B0RM05 BXGT001851 Diguanylate cyclase unreviewed XCCB100_0261 - - - 293 -
P10644 BXGT007597 cAMP-dependent protein kinase type I-alpha regulatory subunit reviewed PRKAR1A - - - - -
G0GA88 BXGT003361 Putative transcriptional regulator, Crp/Fnr family unreviewed Spith_0644 - - - - -
Q6MLN6 BXGT024213 Uncharacterized protein unreviewed Bd1971 - - - - -
P11541 BXGT024884 Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha reviewed PDE6A - - - - -
P23439 BXGT024885 Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta reviewed PDE6B - - - - -
Binding DB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
CHEMBL CHEMBL395336
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
E1BN64 BXGT003068 Phosphodiesterase unreviewed - PDE3B IC50 '=' 100 nM
O35956 BXGT004543 Solute carrier family 22 member 6 reviewed - Slc22a6 Activity - - -
O15439 BXGT004169 Multidrug resistance-associated protein 4 reviewed Transporter ABCC4 Activity '=' 46 %
Q13370 BXGT013345 cGMP-inhibited 3',5'-cyclic phosphodiesterase B reviewed - PDE3B IC50 '=' 2400 nM
Q14432 BXGT013469 cGMP-inhibited 3',5'-cyclic phosphodiesterase A reviewed - PDE3A IC50 '=' 2400 nM
O15439 BXGT004169 Multidrug resistance-associated protein 4 reviewed Transporter ABCC4 Activity - - -
O15440 BXGT004170 Multidrug resistance-associated protein 5 reviewed Transporter ABCC5 Km '=' 2100 nM
O15439 BXGT004169 Multidrug resistance-associated protein 4 reviewed Transporter ABCC4 Activity '=' 16 %
O15439 BXGT004169 Multidrug resistance-associated protein 4 reviewed Transporter ABCC4 Km '=' 9690 nM
O15440 BXGT004170 Multidrug resistance-associated protein 5 reviewed Transporter ABCC5 Activity '=' 37 %
Q96J66 BXGT019680 ATP-binding cassette sub-family C member 11 reviewed Transporter ABCC11 Activity '=' 73 %
O15439 BXGT004169 Multidrug resistance-associated protein 4 reviewed Transporter ABCC4 Activity '=' 48 %
Q9Y694 BXGT022321 Solute carrier family 22 member 7 reviewed Transporter SLC22A7 FC '=' 97 -
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF04698 Isodon rubescens Isodon rubescens Others
BXGF05571 Ziziphus jujuba Ziziphus jujuba Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease