acompound

Showing entry for Uridine

General Compound Information
BXGC Id	BXGC0044087
Compound Name	Uridine
Structure
Formula	C9H12N2O6
InchiKey	DRTQHJPVMGBUCF-XVFCMESISA-N
SMILES	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1ccc(nc1=O)O
Inchi	InChI=1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1
IUPAC	1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
Molecular Weight	244.07
Pubchem Id	6029
Chembl Id	CHEMBL100259

Targets of Information Source

DrugBank

DB02745

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type
P62312	BXGT011419	U6 snRNA-associated Sm-like protein LSm6	reviewed	-	LSM6	experimental; investigational	-
P0A927	BXGT007167	Nucleoside-specific channel-forming protein Tsx	reviewed	-	tsx	experimental; investigational	-

PDB

URI

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
O29386	BXGT004338	Putative snRNP Sm-like protein	reviewed	AF_0875	-	-	-	-	-
Q8ZYG5	BXGT019263	Small nuclear ribonucleoprotein homolog (Sm-like)	unreviewed	PAE0790	-	-	-	-	-
O26745	BXGT004277	Putative snRNP Sm-like protein	reviewed	MTH_649	-	-	-	-	-
P0A927	BXGT007167	Nucleoside-specific channel-forming protein Tsx	reviewed	tsx	-	-	-	-	-
P56389	BXGT011166	Cytidine deaminase	reviewed	Cda	-	-	-	-	-
P0A1F6	BXGT006985	Uridine phosphorylase	reviewed	udp	-	-	-	-	-
P43889	BXGT010419	Bifunctional protein GlmU	reviewed	glmU	-	-	-	-	-
A0A0H2VD83	BXGT000290	Uncharacterized protein	unreviewed	c4898	-	-	-	-	-
Q9KPL5	BXGT020968	Nucleoside permease	unreviewed	VC_2352	-	-	-	-	-
Q9KSM5	BXGT020992	Cytidine deaminase	reviewed	cdd	-	-	-	-	-
D0C9L6	BXGT002668	Peptidyl-tRNA hydrolase	unreviewed	pth	-	-	-	1.4	-
Q9KPL5	BXGT020968	Nucleoside permease	unreviewed	VC_2352	-	-	-	36000	-
Q9NR97	BXGT021182	Toll-like receptor 8	reviewed	TLR8	-	-	-	55000	-
Q9NR97	BXGT021182	Toll-like receptor 8	reviewed	TLR8	-	-	-	-	-
Q8E9X9	BXGT018079	Uridine phosphorylase	unreviewed	udp	-	-	-	-	-
Q7CP66	BXGT016935	Thymidine phosphorylase	reviewed	deoA	-	-	-	-	-
Q9K4U1	BXGT020874	Uridine phosphorylase	unreviewed	udp	-	-	-	-	-
D9J2T9	BXGT003028	Ribosome inactivating protein	unreviewed	RIP	-	-	-	-	-
G4CRQ5	BXGT003500	Nucleoside permease	unreviewed	nupC	-	-	-	-	-
E2EKP5	BXGT003083	Putative cupin_2 domain-containing isomerase	unreviewed	pac13	-	-	-	-	-
X2KZJ9	BXGT024343	UTP--glucose-1-phosphate uridylyltransferase	unreviewed	galU	-	-	-	-	-

Binding DB

50088517

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
reviewed	BXGT020507	Solute carrier family 28 member 3	reviewed	Transporter	SLC28A3	3400	-	-	-
reviewed	BXGT020507	Solute carrier family 28 member 3	reviewed	Transporter	SLC28A3	-	5400	-	-
reviewed	BXGT004631	Sodium/nucleoside cotransporter 2	reviewed	Transporter	SLC28A2	31000	-	-	-
reviewed	BXGT004631	Sodium/nucleoside cotransporter 2	reviewed	Transporter	SLC28A2	-	32000	-	-
reviewed	BXGT003911	Sodium/nucleoside cotransporter 1	reviewed	Transporter	SLC28A1	5200	-	-	-
reviewed	BXGT003911	Sodium/nucleoside cotransporter 1	reviewed	Transporter	SLC28A1	-	5800	-	-
reviewed	BXGT013482	Equilibrative nucleoside transporter 2	reviewed	Transporter	SLC29A2	242000	-	-	-
reviewed	BXGT013482	Equilibrative nucleoside transporter 2	reviewed	Transporter	SLC29A2	-	234000	-	-
reviewed	BXGT019964	Equilibrative nucleoside transporter 1	reviewed	Transporter	SLC29A1	51000	-	-	-
reviewed	BXGT019964	Equilibrative nucleoside transporter 1	reviewed	Transporter	SLC29A1	-	52000	-	-

CHEMBL

CHEMBL100259

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	width="10%">Type	Relation	value	Units
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Type	Relation	value	Units
P27158	BXGT009160	Thymidine kinase, cytosolic	reviewed	-	Tk1	Inhibition	'='	4	%
O43868	BXGT004631	Sodium/nucleoside cotransporter 2	reviewed	Transporter	SLC28A2	Drug transport	-	-	-
O95398	BXGT005378	Rap guanine nucleotide exchange factor 3	reviewed	Enzyme modulator	RAPGEF3	Potency	-	125892	nM
D3ZGQ2	BXGT002918	Thymidine kinase 2	unreviewed	-	Tk2	Inhibition	'='	4	%
Q9HA47	BXGT020503	Uridine-cytidine kinase 1	reviewed	Kinase	UCK1	Kcat	'='	0	/s
P07650	BXGT006654	Thymidine phosphorylase	reviewed	-	deoA	Activity	'='	56	%
P27708	BXGT009202	CAD protein	reviewed	Enzyme	CAD	Activity	'='	100	%
O00337	BXGT003911	Sodium/nucleoside cotransporter 1	reviewed	Transporter	SLC28A1	Drug transport	-	-	-
Q194T2	BXGT013743	Non-structural protein 1	unreviewed	-	NS1	Potency	'='	12589	nM
P07650	BXGT006654	Thymidine phosphorylase	reviewed	-	deoA	Activity	'='	81	%
Q9HA47	BXGT020503	Uridine-cytidine kinase 1	reviewed	Kinase	UCK1	Kcat/Km	'='	0	/uM/s
Q9HA47	BXGT020503	Uridine-cytidine kinase 1	reviewed	Kinase	UCK1	Km	'='	407000	nM
Q9F4F7	BXGT020344	4'-phosphopantetheinyl transferase ffp	reviewed	-	ffp	Potency	'='	100000	nM
Q9HAS3	BXGT020507	Solute carrier family 28 member 3	reviewed	Transporter	SLC28A3	Ki	'='	3400	nM
Q14542	BXGT013482	Equilibrative nucleoside transporter 2	reviewed	Transporter	SLC29A2	Ki	'='	242000	nM
Q14542	BXGT013482	Equilibrative nucleoside transporter 2	reviewed	Transporter	SLC29A2	IC50	'='	234000	nM
P22629	BXGT008788	Streptavidin	reviewed	-		Activity	-	-	-
Q9HAS3	BXGT020507	Solute carrier family 28 member 3	reviewed	Transporter	SLC28A3	Drug transport	-	-	-
Q9UNA4	BXGT021785	DNA polymerase iota	reviewed	-	POLI	Potency	-	89125	nM
O00337	BXGT003911	Sodium/nucleoside cotransporter 1	reviewed	Transporter	SLC28A1	IC50	'='	5800	nM
P27695	BXGT009199	DNA-(apurinic or apyrimidinic site) lyase	reviewed	-	APEX1	Potency	-	50118	nM
Q9F4F7	BXGT020344	4'-phosphopantetheinyl transferase ffp	reviewed	-	ffp	Potency	'='	89125	nM
P32320	BXGT009622	Cytidine deaminase	reviewed	Enzyme	CDA	Ki	'='	0	nM
P08037	BXGT006717	Beta-1,4-galactosyltransferase 1	reviewed	-	B4GALT1	Inhibition	-	-	-
O43868	BXGT004631	Sodium/nucleoside cotransporter 2	reviewed	Transporter	SLC28A2	Ki	'='	31000	nM
O00337	BXGT003911	Sodium/nucleoside cotransporter 1	reviewed	Transporter	SLC28A1	Ki	'='	5200	nM
O43868	BXGT004631	Sodium/nucleoside cotransporter 2	reviewed	Transporter	SLC28A2	IC50	'='	32000	nM
O75496	BXGT005132	Geminin	reviewed	-	GMNN	Potency	-	1258	nM
Q8KHJ3	BXGT018422	Alpha 1,4 galactosyltransferase	unreviewed	-	lgtC	Inhibition	-	-	-
Q9HAS3	BXGT020507	Solute carrier family 28 member 3	reviewed	Transporter	SLC28A3	IC50	'='	5400	nM
Q99808	BXGT019964	Equilibrative nucleoside transporter 1	reviewed	Transporter	SLC29A1	Ki	'='	51000	nM
Q99808	BXGT019964	Equilibrative nucleoside transporter 1	reviewed	Transporter	SLC29A1	IC50	'='	52000	nM

Foods containing the compound

Foods

BXGF Id	Food Name	Scientific Name	Food Group
BXGF Id	Food Name	Scientific Name	Food Group
BXGF00013	Dill	Anethum graveolens	Herbs and Spices
BXGF00019	Tarragon	Artemisia dracunculus	Herbs and Spices
BXGF00040	Pepper (C. annuum)	Capsicum annuum	Vegetables
BXGF00042	Safflower	Carthamus tinctorius	Herbs and Spices
BXGF00043	Caraway	Carum carvi	Herbs and Spices
BXGF00301	Cherimoya	Annona cherimola	Fruits
BXGF00522	Narrowleaf cattail	Typha angustifolia	Vegetables
BXGF01060	Baccharis grandicapitulata	Baccharis grandicapitulata	Others
BXGF01079	Renealmia alpinia	Renealmia alpinia	Human Edible Plant
BXGF01093	Fritillaria pallidiflora	Fritillaria pallidiflora	Medicinal Plant
BXGF01207	Morella pensylvanica	Morella pensylvanica	Others
BXGF01267	Dendrobium chrysanthum	Dendrobium chrysanthum	Medicinal Plant
BXGF01276	Delphinium giraldii	Delphinium giraldii	Medicinal Plant
BXGF01324	Albizia julibrissin	Albizia julibrissin	Medicinal Plant
BXGF01337	Stellaria media	Stellaria media	Medicinal Plant
BXGF01347	Fritillaria delavayi	Fritillaria delavayi	Medicinal Plant
BXGF01413	Fritillaria verticillata	Fritillaria verticillata	Medicinal Plant
BXGF01479	Fritillaria cirrhosa	Fritillaria cirrhosa	Medicinal Plant
BXGF01493	Curcuma aeruginosa	Curcuma aeruginosa	Medicinal Plant
BXGF01540	Rhodomyrtus tomentosa	Rhodomyrtus tomentosa	Medicinal Plant
BXGF01603	Piper brachystachyum	Piper brachystachyum	Medicinal Plant
BXGF01688	Tephroseris kirilowii	Tephroseris kirilowii	Medicinal Plant
BXGF01776	Fritillaria prezewalskii	Fritillaria prezewalskii	Others
BXGF01911	Bupleurum scorzonerifolium	Bupleurum scorzonerifolium	Medicinal Plant
BXGF01913	Fritillaria unibracteata	Fritillaria unibracteata	Medicinal Plant
BXGF01967	Senecio congestus	Senecio congestus	Medicinal Plant
BXGF02124	Papaver pseudocanescens	Papaver pseudocanescens	Others
BXGF02242	Sideritis dasygnaphala	Sideritis dasygnaphala	Others
BXGF02382	Gutierrezia dracunculoides	Gutierrezia dracunculoides	Others
BXGF02423	Psidium acutangulum	Psidium acutangulum	Human Edible Plant
BXGF02440	Beesia calthifolia	Beesia calthifolia	Others
BXGF02483	Bursera kerberi	Bursera kerberi	Others
BXGF02514	Helenium integrifolium	Helenium integrifolium	Others
BXGF02543	Rhododendron mucronulatum	Rhododendron mucronulatum	Medicinal Plant
BXGF02570	Euonymus fortunei	Euonymus fortunei	Medicinal Plant
BXGF02613	Phlomis crinita	Phlomis crinita	Medicinal Plant
BXGF02631	Solanum torvum	Solanum torvum	Medicinal Plant
BXGF02665	Crotalaria stolzii	Crotalaria stolzii	Others
BXGF02682	Selinum libanotis	Selinum libanotis	Others
BXGF02718	Melampodium leucanthum	Melampodium leucanthum	Others
BXGF02725	Fritillaria walujewii	Fritillaria walujewii	Medicinal Plant
BXGF02734	Clerodendrum trichotomum	Clerodendrum trichotomum	Medicinal Plant
BXGF02750	Juniperus scopulorum	Juniperus scopulorum	Medicinal Plant
BXGF02785	Clinacanthus nutans	Clinacanthus nutans	Medicinal Plant
BXGF02815	Pinellia ternata	Pinellia ternata	Medicinal Plant
BXGF02827	Alstonia angustiloba	Alstonia angustiloba	Others
BXGF02840	Lasianthaea podocephala	Lasianthaea podocephala	Others
BXGF02847	Podocarpus elongata	Podocarpus elongata	Others
BXGF02855	Eucalyptus albens	Eucalyptus albens	Others
BXGF02908	Pellacalyx axillaris	Pellacalyx axillaris	Others
BXGF02950	Boschniakia rossica	Boschniakia rossica	Medicinal Plant
BXGF02967	Palicourea alpina	Palicourea alpina	Others
BXGF02982	Lupinus formosus	Lupinus formosus	Others
BXGF02995	Wunderlichia mirabilis	Wunderlichia mirabilis	Others
BXGF03010	Posoqueria latifolia	Posoqueria latifolia	Human Edible Plant
BXGF03026	Dicliptera riparia	Dicliptera riparia	Medicinal Plant
BXGF03036	Oxandra xylopioides	Oxandra xylopioides	Others
BXGF03091	Ilex kaushue	Ilex kaushue	Human Edible Plant
BXGF03116	Dalbergia frutescens	Dalbergia frutescens	Others
BXGF03128	Colchicum macedonicum	Colchicum macedonicum	Others
BXGF03137	Euphorbia caducifolia	Euphorbia caducifolia	Medicinal Plant
BXGF03145	Boronia muelleri	Boronia muelleri	Others
BXGF03161	Dendrobium chrysotoxum	Dendrobium chrysotoxum	Medicinal Plant
BXGF03169	Coprosma acerosa	Coprosma acerosa	Medicinal Plant
BXGF03183	Astilbe koreana	Astilbe koreana	Others
BXGF03211	Scrophularia smithii	Scrophularia smithii	Others
BXGF03302	Hypericum papuanum	Hypericum papuanum	Medicinal Plant
BXGF03329	Zilla spinosa	Zilla spinosa	Medicinal Plant
BXGF03346	Dendrobium candidum	Dendrobium candidum	Others
BXGF03348	Panax notoginseng	Panax notoginseng	Medicinal Plant
BXGF03380	Kaunia arbuscularis	Kaunia arbuscularis	Others
BXGF03397	Trifolium pratense	Trifolium pratense	Medicinal Plant
BXGF03425	Sambucus ebulus	Sambucus ebulus	Medicinal Plant
BXGF03439	Fritillaria przewalskii	Fritillaria przewalskii	Medicinal Plant
BXGF03441	Inula thapsoides	Inula thapsoides	Others
BXGF03444	Gastrodia elata	Gastrodia elata	Medicinal Plant
BXGF03453	Tylophora flava	Tylophora flava	Others
BXGF03474	Limeum pterocarpum	Limeum pterocarpum	Others
BXGF03489	Trifolium alexandrium	Trifolium alexandrium	Medicinal Plant
BXGF03490	Atractylodes macrocephala koidz	Atractylodes macrocephala koidz	Others
BXGF03498	Coptis deltoidea	Coptis deltoidea	Medicinal Plant
BXGF03517	Cassia carnaval	Cassia carnaval	Others
BXGF03537	Salix sieboldiana	Salix sieboldiana	Others
BXGF03632	Dendrobium fimbriatum	Dendrobium fimbriatum	Medicinal Plant
BXGF03811	Euryale ferox	Euryale ferox	Medicinal Plant
BXGF03817	Coffea liberica var. dewevrei	Coffea liberica var. dewevrei	Medicinal Plant
BXGF03868	Dillenia papuana	Dillenia papuana	Others
BXGF03879	Arisaema heterophyllum	Arisaema heterophyllum	Medicinal Plant
BXGF03892	Sesamum indicum	Sesamum indicum	0
BXGF04011	Botrychium ternatum	Botrychium ternatum	Medicinal Plant
BXGF04103	Fritillaria taipaiensis	Fritillaria taipaiensis	Others
BXGF04585	Arisaema amurense	Arisaema amurense	Medicinal Plant
BXGF04600	Typha orientalis	Typha orientalis	Medicinal Plant
BXGF04680	Eschweilera coriacea	Eschweilera coriacea	Human Edible Plant
BXGF04855	Cranfillia vulcanica	Cranfillia vulcanica	Others
BXGF04875	Bupleurum chinense	Bupleurum chinense	Medicinal Plant
BXGF04902	Lupinus cosentinii	Lupinus cosentinii	Others
BXGF04981	Bupleurum falcatum	Bupleurum falcatum	Medicinal Plant
BXGF05159	Eucalyptus cladocalyx	Eucalyptus cladocalyx	Medicinal Plant
BXGF05173	Dendrobium nobile	Dendrobium nobile	Medicinal Plant
BXGF05281	Fritillaria thunbergii	Fritillaria thunbergii	Medicinal Plant
BXGF05297	Isatis tinctoria	Isatis tinctoria	Medicinal Plant
BXGF05318	Hedysarum gmelini	Hedysarum gmelini	Others
BXGF05336	Tanacetum santolinoides	Tanacetum santolinoides	Human Edible Plant
BXGF05338	Persicaria thunbergii	Persicaria thunbergii	Medicinal Plant
BXGF05421	Tussilago farfara	Tussilago farfara	Medicinal Plant
BXGF05465	Euploca racemosa	Euploca racemosa	Others
BXGF05499	Arisaema erubescens	Arisaema erubescens	Medicinal Plant
BXGF05505	Fritillaria ussuriensis	Fritillaria ussuriensis	Medicinal Plant
BXGF05510	Ulva pertusa	Ulva pertusa	Medicinal Plant
BXGF05571	Ziziphus jujuba	Ziziphus jujuba	Medicinal Plant
BXGF05688	Salvadora persica	Salvadora persica	Medicinal Plant
BXGF05705	Pseudostellaria heterophylla	Pseudostellaria heterophylla	Medicinal Plant
BXGF05738	Salvia xalapensis	Salvia xalapensis	Others
BXGF05915	Fritillaria hupehensis	Fritillaria hupehensis	Medicinal Plant
BXGF05962	Rehmannia glutinosa	Rehmannia glutinosa	Medicinal Plant
BXGF05998	Vaccaria hispanica	Vaccaria hispanica	Medicinal Plant
BXGF06053	Ficus elastica	Ficus elastica	Medicinal Plant
BXGF06069	Dendrobium loddigesii	Dendrobium loddigesii	Medicinal Plant
BXGF06143	Persicaria tinctoria	Persicaria tinctoria	Medicinal Plant
BXGF06206	Hydrangea macrophylla	Hydrangea macrophylla	Medicinal Plant
BXGF06271	Artemisia pectinata	Artemisia pectinata	Others
BXGF06307	Zephyranthes flava	Zephyranthes flava	Others
BXGF06321	Peltodon longipes	Peltodon longipes	Others

The compound-realted diseases

Diseases

BXGD Id	Disease Name	CUI Disease Id	Disease Class Name	Number of targets^{?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease}