Showing entry for 2,5-Dideoxy-2,5-Imino-D-Mannitol


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0051203
Compound Name2,5-Dideoxy-2,5-Imino-D-Mannitol
Structure
FormulaC6H13NO4
InchiKeyPFYHYHZGDNWFIF-KVTDHHQDSA-N
SMILESOC[C@H]1N[C@@H]([C@H]([C@@H]1O)O)CO
InchiInChI=1S/C6H13NO4/c8-1-3-5(10)6(11)4(2-9)7-3/h3-11H,1-2H2/t3-,4-,5-,6-/m1/s1
IUPAC(2R,3R,4R,5R)-2,5-bis(hydroxymethyl)pyrrolidine-3,4-diol
Molecular Weight163.08
Pubchem Id124702
Chembl IdCHEMBL312653
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB DQQ
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Q93X60 BXGT019544 Fructan 1-exohydrolase IIa unreviewed 1-feh - - - - -
Binding DB 50031481
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT008901 Sucrase-isomaltase, intestinal reviewed Si - 91000 - -
reviewed BXGT008901 Sucrase-isomaltase, intestinal reviewed Si - 44000 - -
reviewed BXGT008624 Alpha-mannosidase 2C1 reviewed Man2c1 - 260000 - -
reviewed BXGT012651 Lactase-phlorizin hydrolase reviewed Lct - 3600 - -
reviewed BXGT004594 Maltase-glucoamylase, intestinal reviewed Enzyme MGAM - <50000 - -
reviewed BXGT016460 Lysosomal alpha-glucosidase reviewed Gaa - 290000 - -
reviewed BXGT016460 Lysosomal alpha-glucosidase reviewed Gaa - 92000 - -
reviewed BXGT009264 Alpha-mannosidase 2 reviewed Man2a1 - <50000 - -
reviewed BXGT006583 Alpha-glucosidase MAL62 reviewed MAL62 - 2000 - -
reviewed BXGT008901 Sucrase-isomaltase, intestinal reviewed Si - 290000 - -
reviewed BXGT008901 Sucrase-isomaltase, intestinal reviewed Si - 64000 - -
reviewed BXGT009850 Glycogen debranching enzyme reviewed Enzyme AGL - 9800 - -
reviewed BXGT008901 Sucrase-isomaltase, intestinal reviewed Si - 90000 - -
CHEMBL CHEMBL312653
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P28494 BXGT009264 Alpha-mannosidase 2 reviewed - Man2a1 IC50 '<' 50000 nM
Q6P7A9 BXGT016460 Lysosomal alpha-glucosidase reviewed - Gaa IC50 '=' 92000 nM
P23739 BXGT008901 Sucrase-isomaltase, intestinal reviewed - Si IC50 '=' 290000 nM
Q6P7A9 BXGT016460 Lysosomal alpha-glucosidase reviewed - Gaa IC50 - - -
Q9HCG7 BXGT020533 Non-lysosomal glucosylceramidase reviewed - GBA2 Ki '=' 200 nM
P10482 BXGT007574 Beta-glucosidase A reviewed - bglA IC50 '=' 34000 nM
Q9HCG7 BXGT020533 Non-lysosomal glucosylceramidase reviewed - GBA2 IC50 '=' 150000 nM
O43451 BXGT004594 Maltase-glucoamylase, intestinal reviewed Enzyme MGAM IC50 '<' 50000 nM
O70282 BXGT005062 Trehalase unreviewed - IC50 '=' 360000 nM
P21139 BXGT008624 Alpha-mannosidase 2C1 reviewed - Man2c1 IC50 '=' 260000 nM
Q14697 BXGT013501 Neutral alpha-glucosidase AB reviewed Enzyme GANAB IC50 - - -
Q58D55 BXGT015223 Beta-galactosidase reviewed - GLB1 IC50 - - -
O70282 BXGT005062 Trehalase unreviewed - IC50 '=' 200000 nM
I3LIR5 BXGT003674 Trehalase unreviewed - TREH IC50 '=' 500000 nM
D3ZUM4 BXGT002920 Beta-galactosidase unreviewed - Glb1 IC50 - - -
Q2KIM0 BXGT014117 Tissue alpha-L-fucosidase reviewed - FUCA1 Inhibition '<' 50 %
Q9MYM4 BXGT021111 Lysosomal alpha-glucosidase reviewed - GAA IC50 '=' 170000 nM
P23739 BXGT008901 Sucrase-isomaltase, intestinal reviewed - Si IC50 '=' 64000 nM
Q6P7A9 BXGT016460 Lysosomal alpha-glucosidase reviewed - Gaa IC50 '=' 290000 nM
P10482 BXGT007574 Beta-glucosidase A reviewed - bglA IC50 - - -
Q6P762 BXGT016459 Alpha-mannosidase unreviewed - Man2b1 IC50 '<' 50000 nM
Q02401 BXGT012651 Lactase-phlorizin hydrolase reviewed - Lct IC50 '=' 3600 nM
P23739 BXGT008901 Sucrase-isomaltase, intestinal reviewed - Si IC50 '=' 90000 nM
Q8BVW0 BXGT017923 Neutral alpha-glucosidase C reviewed - Ganc IC50 '=' 91000 nM
Q58D55 BXGT015223 Beta-galactosidase reviewed - GLB1 IC50 '=' 3300 nM
P23739 BXGT008901 Sucrase-isomaltase, intestinal reviewed - Si IC50 '=' 44000 nM
P04066 BXGT006142 Tissue alpha-L-fucosidase reviewed - FUCA1 IC50 - - -
P23739 BXGT008901 Sucrase-isomaltase, intestinal reviewed - Si IC50 '=' 91000 nM
P35573 BXGT009850 Glycogen debranching enzyme reviewed Enzyme AGL IC50 '=' 9800 nM
D3ZUM4 BXGT002920 Beta-galactosidase unreviewed - Glb1 IC50 '=' 3600 nM
P23739 BXGT008901 Sucrase-isomaltase, intestinal reviewed - Si Inhibition '<' 50 %
C0HJB3 BXGT002376 Alpha-mannosidase reviewed - Inhibition '<' 50 %
P07265 BXGT006583 Alpha-glucosidase MAL62 reviewed - MAL62 IC50 '=' 2000 nM
I3LIR5 BXGT003674 Trehalase unreviewed - TREH IC50 '=' 200000 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00845 Castanospermum australe Castanospermum australe Vegetables
BXGF02214 Morus bombycis Morus bombycis Medicinal Plant
BXGF02699 Hyacinthus orientalis Hyacinthus orientalis Medicinal Plant
BXGF03204 Xanthocercis zambesiaca Xanthocercis zambesiaca Others
BXGF03999 Angylocalyx pynaertii Angylocalyx pynaertii Others
BXGF04454 Scorzoneroides autumnalis Scorzoneroides autumnalis Others
BXGF04872 Glycyrrhiza glabra Glycyrrhiza glabra Medicinal Plant
BXGF05068 aglaonema treubii aglaonema treubii Others
BXGF05329 Lactuca floridana Lactuca floridana Others
BXGF05790 Glycyrrhiza uralensis Glycyrrhiza uralensis Medicinal Plant
BXGF05936 Commelina communis Commelina communis Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease