Showing entry for Pinosylvin Methyl Ether


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0053078
Compound NamePinosylvin Methyl Ether
Structure
FormulaC15H14O2
InchiKeyJVIXPWIEOVZVJC-BQYQJAHWSA-N
SMILESCOc1cc(/C=C/c2ccccc2)cc(c1)O
InchiInChI=1S/C15H14O2/c1-17-15-10-13(9-14(16)11-15)8-7-12-5-3-2-4-6-12/h2-11,16H,1H3/b8-7+
IUPAC3-methoxy-5-[(E)-2-phenylethenyl]phenol
Molecular Weight226.1
Pubchem Id5281719
Chembl IdCHEMBL186366
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 50140143
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT018556 Transient receptor potential cation channel subfamily V member 1 reviewed Ion channel TRPV1 - >10000 - -
reviewed BXGT016509 Transient receptor potential cation channel subfamily A member 1 reviewed Trpa1 - - - 3500
reviewed BXGT018556 Transient receptor potential cation channel subfamily V member 1 reviewed Ion channel TRPV1 - 23700 - -
reviewed BXGT018556 Transient receptor potential cation channel subfamily V member 1 reviewed Ion channel TRPV1 - 15000 - -
reviewed BXGT018556 Transient receptor potential cation channel subfamily V member 1 reviewed Ion channel TRPV1 - 30000 - -
reviewed BXGT016509 Transient receptor potential cation channel subfamily A member 1 reviewed Trpa1 - 6900 - -
CHEMBL CHEMBL186366
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 39810 nM
P43220 BXGT010367 Glucagon-like peptide 1 receptor reviewed G-protein coupled receptor GLP1R Potency - 28183 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 28183 nM
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 456 %
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 19952 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 35481 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 25929 nM
Q6RI86 BXGT016509 Transient receptor potential cation channel subfamily A member 1 reviewed - Trpa1 IC50 '=' 6900 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 19952 nM
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 28183 nM
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 50118 nM
O75874 BXGT005157 Isocitrate dehydrogenase [NADP] cytoplasmic reviewed - IDH1 Potency - 29092 nM
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency '=' 7943 nM
Q6RI86 BXGT016509 Transient receptor potential cation channel subfamily A member 1 reviewed - Trpa1 Efficacy '=' 71 %
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency '=' 10000 nM
Q8NER1 BXGT018556 Transient receptor potential cation channel subfamily V member 1 reviewed Ion channel TRPV1 IC50 '=' 23700 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 14125 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 14125 nM
Q8NER1 BXGT018556 Transient receptor potential cation channel subfamily V member 1 reviewed Ion channel TRPV1 IC50 '>' 10000 nM
Q6RI86 BXGT016509 Transient receptor potential cation channel subfamily A member 1 reviewed - Trpa1 EC50 '=' 3500 nM
Q16637 BXGT013646 Survival motor neuron protein reviewed Epigenetic regulator SMN1 Potency '=' 25118 nM
P38398 BXGT010037 Breast cancer type 1 susceptibility protein reviewed Enzyme BRCA1 Potency - 3162 nM
O75604 BXGT005139 Ubiquitin carboxyl-terminal hydrolase 2 reviewed Enzyme USP2 Potency '=' 25118 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 31622 nM
Q03431 BXGT012714 Parathyroid hormone/parathyroid hormone-related peptide receptor reviewed G-protein coupled receptor PTH1R Potency - 112201 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 25118 nM
P63092 BXGT011495 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short reviewed - GNAS Potency - 3548 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 29092 nM
P37840 BXGT010015 Alpha-synuclein reviewed Transporter SNCA Potency - 28183 nM
O75762 BXGT005151 Transient receptor potential cation channel subfamily A member 1 reviewed Ion channel TRPA1 FC '=' 0 -
Q8NER1 BXGT018556 Transient receptor potential cation channel subfamily V member 1 reviewed Ion channel TRPV1 Efficacy '<' 10 %
Q8NER1 BXGT018556 Transient receptor potential cation channel subfamily V member 1 reviewed Ion channel TRPV1 IC50 '=' 30000 nM
O75762 BXGT005151 Transient receptor potential cation channel subfamily A member 1 reviewed Ion channel TRPA1 FC '=' 0 -
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 91 %
Q8NER1 BXGT018556 Transient receptor potential cation channel subfamily V member 1 reviewed Ion channel TRPV1 IC50 '=' 15000 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00074 Cardamom Elettaria cardamomum Herbs and Spices
BXGF00305 Chinese chestnut Castanea mollissima Nuts
BXGF00884 Eria linearifolia Eria linearifolia Others
BXGF01248 Pinus banksiana Pinus banksiana Medicinal Plant
BXGF01299 Firmiana simplex Firmiana simplex Medicinal Plant
BXGF01355 Amomum krervanh Amomum krervanh Medicinal Plant
BXGF01411 Waitzia acuminata Waitzia acuminata Others
BXGF01497 Polypodiodes niponica Polypodiodes niponica Human Edible Plant
BXGF01757 Centaurea zuccariniana Centaurea zuccariniana Others
BXGF01775 Phagnalon rupestre Phagnalon rupestre Medicinal Plant
BXGF02437 Piliostigma thonningii Piliostigma thonningii Medicinal Plant
BXGF02656 Dalbergia sissoo Dalbergia sissoo Medicinal Plant
BXGF03033 Aristolochia triangularis Aristolochia triangularis Medicinal Plant
BXGF03293 Crinum giganteum Crinum giganteum Others
BXGF03316 Titanotrichum oldhamii Titanotrichum oldhamii Others
BXGF03591 Ammodendron karelinii Ammodendron karelinii Others
BXGF03752 Buglossoides arvensis Buglossoides arvensis Medicinal Plant
BXGF04292 Bowdichia virgilioides Bowdichia virgilioides Medicinal Plant
BXGF04502 Mimusops laurifolia Mimusops laurifolia Human Edible Plant
BXGF04530 Salvia pisidica Salvia pisidica Medicinal Plant
BXGF04549 Pentachondra pumila Pentachondra pumila Medicinal Plant
BXGF04565 Ursinia speciosa Ursinia speciosa Others
BXGF04575 Anacyclus pyrethrum Anacyclus pyrethrum Medicinal Plant
BXGF04581 Brachylaena perrieri Brachylaena perrieri Others
BXGF04596 Diplotropis ferruginea Diplotropis ferruginea Others
BXGF04608 Phlomis ostrowskiana Phlomis ostrowskiana Others
BXGF04622 Uncaria longiflora Uncaria longiflora Medicinal Plant
BXGF04628 Pimpinella peregrina Pimpinella peregrina Human Edible Plant
BXGF04649 Medicosma fareana Medicosma fareana Others
BXGF04656 Solanum crinitum Solanum crinitum Others
BXGF04663 Mentha sylvestris Mentha sylvestris Medicinal Plant
BXGF04668 Euphrasia regelii Euphrasia regelii Medicinal Plant
BXGF04671 Hortonia angustifolia Hortonia angustifolia Others
BXGF04688 Julbernardia globifera Julbernardia globifera Others
BXGF04697 Phlox decussata Phlox decussata Others
BXGF04704 Tubocapsicum anomalum Tubocapsicum anomalum Human Edible Plant
BXGF04711 Cuscuta australis Cuscuta australis Medicinal Plant
BXGF04713 Aster tataricus Aster tataricus Medicinal Plant
BXGF04717 Salvia lanigera Salvia lanigera Medicinal Plant
BXGF04722 Othonna macrophylla Othonna macrophylla Others
BXGF04724 Miliusa balansae Miliusa balansae Others
BXGF04726 Eucalyptus viminalis Eucalyptus viminalis Medicinal Plant
BXGF04732 Laggera pterodonta Laggera pterodonta Medicinal Plant
BXGF04740 Acronychia haplophylla Acronychia haplophylla Medicinal Plant
BXGF04745 Salix petiolaris Salix petiolaris Others
BXGF04750 Scutellaria baicalensis Scutellaria baicalensis Medicinal Plant
BXGF04752 Pinus monticola Pinus monticola Medicinal Plant
BXGF04763 Myrrhis odorata Myrrhis odorata Medicinal Plant
BXGF04797 Tinospora hainanensis Tinospora hainanensis Medicinal Plant
BXGF04849 Pinus excelsa Pinus excelsa Medicinal Plant
BXGF04976 Arachniodes exilis Arachniodes exilis Medicinal Plant
BXGF05095 Wrightia tinctoria Wrightia tinctoria Medicinal Plant
BXGF05149 Amentotaxus argotaenia Amentotaxus argotaenia Others
BXGF05209 Veronica anagallis Veronica anagallis Medicinal Plant
BXGF05226 Scutia buxifolia Scutia buxifolia Medicinal Plant
BXGF05346 Acacia simplicifolia Acacia simplicifolia Others
BXGF05449 Tetradenia glauca Tetradenia glauca Others
BXGF05970 Nauclea parva Nauclea parva Others
BXGF05984 Cressa cretica Cressa cretica Medicinal Plant
BXGF06024 Uvaria microcarpa Uvaria microcarpa Human Edible Plant
BXGF06123 Cousinia canescens Cousinia canescens Others
BXGF06192 Parkia clappertoniana Parkia clappertoniana Human Edible Plant
BXGF06239 Pericopsis angolensis Pericopsis angolensis Medicinal Plant
BXGF06314 Teucrium scorodonia Teucrium scorodonia Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease