adisease

Showing entry for Drug habituation

General Disease Information
BXGD Id	BXGD000802
Disease Name	Drug habituation
Disease CUI Id	C0013170
MeSH Codes	C25 F03
Disease Class Name	Chemically-Induced Disorders; Mental Disorders
Semantic Type	Mental or Behavioral Dysfunction
Human Phenotype Ontology Id
Human Phenotype Ontology Term
Disease Ontology Id
Disease Ontology Class Name
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
A1Z1Q3	BXGT001069	ADP-ribose glycohydrolase MACROD2	140733	reviewed
O00519	BXGT003934	Fatty-acid amide hydrolase 1	2166	reviewed
O15439	BXGT004169	Multidrug resistance-associated protein 4	10257	reviewed	Transporter
O43612	BXGT004605	Orexin	3060	reviewed
O75385	BXGT005121	Serine/threonine-protein kinase ULK1	8408	reviewed	Kinase
O75751	BXGT005150	Solute carrier family 22 member 3	6581	reviewed	Transporter
P01189	BXGT005742	Pro-opiomelanocortin	5443	reviewed
P01275	BXGT005747	Glucagon	2641	reviewed
P01303	BXGT005748	Pro-neuropeptide Y	4852	reviewed	Signaling
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P02649	BXGT005909	Apolipoprotein E	348	reviewed
P04150	BXGT006154	Glucocorticoid receptor	2908	reviewed	Nuclear receptor
P05026	BXGT006296	Sodium/potassium-transporting ATPase subunit beta-1	481	reviewed	Transporter
P05164	BXGT006333	Myeloperoxidase	4353	reviewed	Enzyme
P05231	BXGT006345	Interleukin-6	3569	reviewed
P06213	BXGT006425	Insulin receptor	3643	reviewed	Kinase
P06850	BXGT006511	Corticoliberin	1392	reviewed	Signaling
P07108	BXGT006551	Acyl-CoA-binding protein	1622	reviewed	Enzyme modulator
P08172	BXGT006737	Muscarinic acetylcholine receptor M2	1129	reviewed	G-protein coupled receptor
P08908	BXGT006837	5-hydroxytryptamine receptor 1A	3350	reviewed	G-protein coupled receptor
P10635	BXGT007595	Cytochrome P450 2D6	1565	reviewed
P12821	BXGT007849	Angiotensin-converting enzyme	1636	reviewed	Enzyme
P13569	BXGT007923	Cystic fibrosis transmembrane conductance regulator	1080	reviewed	Ion channel
P14416	BXGT008011	D(2) dopamine receptor	1813	reviewed	G-protein coupled receptor
P15884	BXGT008166	Transcription factor 4	6925	reviewed	Transcription factor
P16220	BXGT008206	Cyclic AMP-responsive element-binding protein 1	1385	reviewed
P19113	BXGT008458	Histidine decarboxylase	3067	reviewed
P19838	BXGT008526	Nuclear factor NF-kappa-B p105 subunit	4790	reviewed	Transcription factor
P21554	BXGT008662	Cannabinoid receptor 1	1268	reviewed	G-protein coupled receptor
P21917	BXGT008707	D(4) dopamine receptor	1815	reviewed	G-protein coupled receptor
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P24723	BXGT008989	Protein kinase C eta type	5583	reviewed	Kinase
P25942	BXGT009079	Tumor necrosis factor receptor superfamily member 5	958	reviewed
P28223	BXGT009239	5-hydroxytryptamine receptor 2A	3356	reviewed	G-protein coupled receptor
P28907	BXGT009301	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	952	reviewed	Enzyme
P30532	BXGT009433	Neuronal acetylcholine receptor subunit alpha-5	1138	reviewed	Ion channel
P31645	BXGT009558	Sodium-dependent serotonin transporter	6532	reviewed	Transporter
P32297	BXGT009616	Neuronal acetylcholine receptor subunit alpha-3	1136	reviewed	Ion channel
P35372	BXGT009823	Mu-type opioid receptor	4988	reviewed	G-protein coupled receptor
P40967	BXGT010212	Melanocyte protein PMEL	6490	reviewed	Signaling
P41143	BXGT010223	Delta-type opioid receptor	4985	reviewed	G-protein coupled receptor
P41212	BXGT010235	Transcription factor ETV6	2120	reviewed	Transcription factor
P41594	BXGT010266	Metabotropic glutamate receptor 5	2915	reviewed	G-protein coupled receptor
P42261	BXGT010293	Glutamate receptor 1	2890	reviewed	Ion channel
P42345	BXGT010304	Serine/threonine-protein kinase mTOR	2475	reviewed	Kinase
P42898	BXGT010344	Methylenetetrahydrofolate reductase	4524	reviewed
P43005	BXGT010349	Excitatory amino acid transporter 3	6505	reviewed	Transporter
P48058	BXGT010614	Glutamate receptor 4	2893	reviewed	Ion channel
P49789	BXGT010742	Bis(5'-adenosyl)-triphosphatase	2272	reviewed
P50135	BXGT010776	Histamine N-methyltransferase	3176	reviewed
P50993	BXGT010826	Sodium/potassium-transporting ATPase subunit alpha-2	477	reviewed	Transporter
P80365	BXGT011895	Corticosteroid 11-beta-dehydrogenase isozyme 2	3291	reviewed	Enzyme
P98164	BXGT012230	Low-density lipoprotein receptor-related protein 2	4036	reviewed
Q00653	BXGT012541	Nuclear factor NF-kappa-B p100 subunit	4791	reviewed	Transcription factor
Q02156	BXGT012639	Protein kinase C epsilon type	5581	reviewed	Kinase
Q06187	BXGT012860	Tyrosine-protein kinase BTK	695	reviewed	Kinase
Q06787	BXGT012890	Synaptic functional regulator FMR1	2332	reviewed	Nucleic acid binding
Q12791	BXGT013264	Calcium-activated potassium channel subunit alpha-1	3778	reviewed	Ion channel
Q12879	BXGT013275	Glutamate receptor ionotropic, NMDA 2A	2903	reviewed	Ion channel
Q12908	BXGT013278	Ileal sodium/bile acid cotransporter	6555	reviewed	Transporter
Q13002	BXGT013303	Glutamate receptor ionotropic, kainate 2	2898	reviewed	Ion channel
Q13224	BXGT013328	Glutamate receptor ionotropic, NMDA 2B	2904	reviewed	Ion channel
Q14123	BXGT013445	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	5137	reviewed
Q14831	BXGT013506	Metabotropic glutamate receptor 7	2917	reviewed	G-protein coupled receptor
Q15020	BXGT013522	Squamous cell carcinoma antigen recognized by T-cells 3	9733	reviewed	Nucleic acid binding
Q16665	BXGT013653	Hypoxia-inducible factor 1-alpha	3091	reviewed	Transcription factor
Q5KU26	BXGT015462	Collectin-12	81035	reviewed	Extracellular structure
Q7KZF4	BXGT016989	Staphylococcal nuclease domain-containing protein 1	27044	reviewed	Transcription factor
Q8WWY3	BXGT019006	U4/U6 small nuclear ribonucleoprotein Prp31	26121	reviewed	Nucleic acid binding
Q92499	BXGT019350	ATP-dependent RNA helicase DDX1	1653	reviewed
Q96QU1	BXGT019721	Protocadherin-15	65217	reviewed
Q99685	BXGT019948	Monoglyceride lipase	11343	reviewed	Enzyme
Q99700	BXGT019949	Ataxin-2	6311	reviewed	Nucleic acid binding
Q9BUB5	BXGT020133	MAP kinase-interacting serine/threonine-protein kinase 1	8569	reviewed	Kinase
Q9BY08	BXGT020177	Emopamil-binding protein-like	84650	reviewed	Enzyme
Q9H227	BXGT020447	Cytosolic beta-glucosidase	57733	reviewed	Enzyme
Q9H2G2	BXGT020452	STE20-like serine/threonine-protein kinase	9748	reviewed	Kinase
Q9NQX4	BXGT021173	Unconventional myosin-Vc	55930	reviewed	Cellular structure
Q9NT68	BXGT021210	Teneurin-2	57451	reviewed
Q9NVD7	BXGT021223	Alpha-parvin	55742	reviewed	Cellular structure
Q9NZQ7	BXGT021281	Programmed cell death 1 ligand 1	29126	reviewed	Receptor
Q9ULW0	BXGT021766	Targeting protein for Xklp2	22974	reviewed	Cellular structure
Q8NEU8	BXGT022976	DCC-interacting protein 13-beta	55198	reviewed
P17752	BXGT023118	Tryptophan 5-hydroxylase 1	7166	reviewed
O43172	BXGT026158	U4/U6 small nuclear ribonucleoprotein Prp4	9128	reviewed	Nucleic acid binding

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}