adisease

Showing entry for Obesity, Morbid

General Disease Information
BXGD Id	BXGD002083
Disease Name	Obesity, Morbid
Disease CUI Id	C0028756
MeSH Codes	C23 C18
Disease Class Name	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id
Human Phenotype Ontology Term
Disease Ontology Id	DOID:0014667
Disease Ontology Class Name	disease of metabolism
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00519	BXGT003934	Fatty-acid amide hydrolase 1	2166	reviewed
O00763	BXGT003947	Acetyl-CoA carboxylase 2	32	reviewed
O00767	BXGT003949	Acyl-CoA desaturase	6319	reviewed
O14594	BXGT004073	Neurocan core protein	1463	reviewed	Extracellular structure
O15123	BXGT004130	Angiopoietin-2	285	reviewed	Signaling
O60240	BXGT004860	Perilipin-1	5346	reviewed
O60603	BXGT004887	Toll-like receptor 2	7097	reviewed
O95644	BXGT005389	Nuclear factor of activated T-cells, cytoplasmic 1	4772	reviewed	Transcription factor
P00156	BXGT005469	Cytochrome b	4519	reviewed
P00390	BXGT005526	Glutathione reductase, mitochondrial	2936	reviewed	Enzyme
P00505	BXGT005560	Aspartate aminotransferase, mitochondrial	2806	reviewed
P00747	BXGT005639	Plasminogen	5340	reviewed	Enzyme
P01106	BXGT005730	Myc proto-oncogene protein	4609	reviewed	Transcription factor
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01189	BXGT005742	Pro-opiomelanocortin	5443	reviewed
P01236	BXGT005744	Prolactin	5617	reviewed	Signaling
P01275	BXGT005747	Glucagon	2641	reviewed
P01303	BXGT005748	Pro-neuropeptide Y	4852	reviewed	Signaling
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P02741	BXGT005936	C-reactive protein	1401	reviewed
P03372	BXGT006059	Estrogen receptor	2099	reviewed	Nuclear receptor
P04278	BXGT006182	Sex hormone-binding globulin	6462	reviewed
P04626	BXGT006238	Receptor tyrosine-protein kinase erbB-2	2064	reviewed	Kinase
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P05121	BXGT006320	Plasminogen activator inhibitor 1	5054	reviewed	Enzyme modulator
P05231	BXGT006345	Interleukin-6	3569	reviewed
P06213	BXGT006425	Insulin receptor	3643	reviewed	Kinase
P06858	BXGT006515	Lipoprotein lipase	4023	reviewed	Enzyme
P07203	BXGT006566	Glutathione peroxidase 1	2876	reviewed	Enzyme
P07550	BXGT006636	Beta-2 adrenergic receptor	154	reviewed	G-protein coupled receptor
P09601	BXGT006909	Heme oxygenase 1	3162	reviewed
P10809	BXGT007617	60 kDa heat shock protein, mitochondrial	3329	reviewed
P10909	BXGT007630	Clusterin	1191	reviewed
P12104	BXGT007773	Fatty acid-binding protein, intestinal	2169	reviewed
P12643	BXGT007830	Bone morphogenetic protein 2	650	reviewed	Signaling
P12821	BXGT007849	Angiotensin-converting enzyme	1636	reviewed	Enzyme
P13945	BXGT007972	Beta-3 adrenergic receptor	155	reviewed	G-protein coupled receptor
P14416	BXGT008011	D(2) dopamine receptor	1813	reviewed	G-protein coupled receptor
P14616	BXGT008026	Insulin receptor-related protein	3645	reviewed	Kinase
P14672	BXGT008037	Solute carrier family 2, facilitated glucose transporter member 4	6517	reviewed	Transporter
P16671	BXGT008255	Platelet glycoprotein 4	948	reviewed	Receptor
P17936	BXGT008357	Insulin-like growth factor-binding protein 3	3486	reviewed	Enzyme modulator
P19440	BXGT008481	Glutathione hydrolase 1 proenzyme	2678	reviewed	Enzyme
P19838	BXGT008526	Nuclear factor NF-kappa-B p105 subunit	4790	reviewed	Transcription factor
P20702	BXGT008592	Integrin alpha-X	3687	reviewed
P21554	BXGT008662	Cannabinoid receptor 1	1268	reviewed	G-protein coupled receptor
P22303	BXGT008751	Acetylcholinesterase	43	reviewed	Enzyme
P22413	BXGT008764	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	5167	reviewed	Enzyme
P22897	BXGT008816	Macrophage mannose receptor 1	4360	reviewed
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P24298	BXGT008960	Alanine aminotransferase 1	2875	reviewed	Enzyme
P25440	BXGT009044	Bromodomain-containing protein 2	6046	reviewed	Epigenetic regulator
P27169	BXGT009161	Serum paraoxonase/arylesterase 1	5444	reviewed
P27487	BXGT009187	Dipeptidyl peptidase 4	1803	reviewed	Enzyme
P32245	BXGT009614	Melanocortin receptor 4	4160	reviewed	G-protein coupled receptor
P35372	BXGT009823	Mu-type opioid receptor	4988	reviewed	G-protein coupled receptor
P37231	BXGT009972	Peroxisome proliferator-activated receptor gamma	5468	reviewed	Nuclear receptor
P37268	BXGT009975	Squalene synthase	2222	reviewed
P40189	BXGT010164	Interleukin-6 receptor subunit beta	3572	reviewed	Signaling
P40763	BXGT010202	Signal transducer and activator of transcription 3	6774	reviewed	Nucleic acid binding
P41968	BXGT010275	Melanocortin receptor 3	4159	reviewed	G-protein coupled receptor
P43220	BXGT010367	Glucagon-like peptide 1 receptor	2740	reviewed	G-protein coupled receptor
P43490	BXGT010395	Nicotinamide phosphoribosyltransferase	10135	reviewed	Signaling
P48357	BXGT010627	Leptin receptor	3953	reviewed	Signaling
P49146	BXGT010681	Neuropeptide Y receptor type 2	4887	reviewed	G-protein coupled receptor
P52594	BXGT010936	Arf-GAP domain and FG repeat-containing protein 1	3267	reviewed
P55087	BXGT011105	Aquaporin-4	361	reviewed	Ion channel
P60484	BXGT011307	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	5728	reviewed	Enzyme
P61981	BXGT011400	14-3-3 protein gamma	7532	reviewed	Chaperone
P62491	BXGT011430	Ras-related protein Rab-11A	8766	reviewed
P63092	BXGT011495	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	2778	reviewed
P80188	BXGT011882	Neutrophil gelatinase-associated lipocalin	3934	reviewed	Enzyme
P81172	BXGT011935	Hepcidin	57817	reviewed
Q03181	BXGT012701	Peroxisome proliferator-activated receptor delta	5467	reviewed	Nuclear receptor
Q04771	BXGT012783	Activin receptor type-1	90	reviewed	Kinase
Q05329	BXGT012814	Glutamate decarboxylase 2	2572	reviewed	Enzyme
Q07869	BXGT012945	Peroxisome proliferator-activated receptor alpha	5465	reviewed	Nuclear receptor
Q12791	BXGT013264	Calcium-activated potassium channel subunit alpha-1	3778	reviewed	Ion channel
Q13501	BXGT013365	Sequestosome-1	8878	reviewed
Q13546	BXGT013372	Receptor-interacting serine/threonine-protein kinase 1	8737	reviewed	Kinase
Q14032	BXGT013438	Bile acid-CoA:amino acid N-acyltransferase	570	reviewed
Q15389	BXGT013564	Angiopoietin-1	284	reviewed	Signaling
Q15848	BXGT013609	Adiponectin	9370	reviewed
Q16568	BXGT013640	Cocaine- and amphetamine-regulated transcript protein	9607	reviewed
Q16665	BXGT013653	Hypoxia-inducible factor 1-alpha	3091	reviewed	Transcription factor
Q16875	BXGT013686	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	5209	reviewed	Kinase
Q5VZ30	BXGT015894	Glutamate decarboxylase 2 (Pancreatic islets and brain, 65kDa)	2572	unreviewed
Q6VAB6	BXGT016576	Kinase suppressor of Ras 2	283455	reviewed	Kinase
Q8NBP7	BXGT018541	Proprotein convertase subtilisin/kexin type 9	255738	reviewed	Enzyme
Q92731	BXGT019366	Estrogen receptor beta	2100	reviewed	Nuclear receptor
Q96EB6	BXGT019646	NAD-dependent protein deacetylase sirtuin-1	23411	reviewed	Epigenetic regulator
Q96RI1	BXGT019727	Bile acid receptor	9971	reviewed	Nuclear receptor
Q9C0B1	BXGT020209	Alpha-ketoglutarate-dependent dioxygenase FTO	79068	reviewed
Q9GZX6	BXGT020428	Interleukin-22	50616	reviewed
Q9NRF2	BXGT021185	SH2B adapter protein 1	25970	reviewed
Q9NZ45	BXGT021269	CDGSH iron-sulfur domain-containing protein 1	55847	reviewed
Q9Y4B6	BXGT022272	DDB1- and CUL4-associated factor 1	9730	reviewed
Q9Y618	BXGT022315	Nuclear receptor corepressor 2	9612	reviewed	Transcription factor
Q9Y6Q9	BXGT022338	Nuclear receptor coactivator 3	8202	reviewed	Kinase
Q9UKG1	BXGT022975	DCC-interacting protein 13-alpha	26060	reviewed
O95140	BXGT024482	Mitofusin-2	9927	reviewed	Enzyme
O14520	BXGT024716	Aquaporin-7	364	reviewed	Ion channel
P23511	BXGT025343	Nuclear transcription factor Y subunit alpha	4800	reviewed	Nucleic acid binding
Q7Z3B1	BXGT025707	Neuronal growth regulator 1	257194	reviewed
Q8NI99	BXGT025986	Angiopoietin-related protein 6	83854	reviewed	Signaling

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}