adisease

Showing entry for Sicca Syndrome

General Disease Information
BXGD Id	BXGD003317
Disease Name	Sicca Syndrome
Disease CUI Id	C0086981
MeSH Codes	C11 C17 C05 C20 C07
Disease Class Name	Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id
Human Phenotype Ontology Term
Disease Ontology Id	DOID:7
Disease Ontology Class Name	disease of anatomical entity
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O15455	BXGT004171	Toll-like receptor 3	7098	reviewed	Receptor
O60858	BXGT004903	E3 ubiquitin-protein ligase TRIM13	10206	reviewed
P00734	BXGT005630	Prothrombin	2147	reviewed	Enzyme
P00751	BXGT005643	Complement factor B	629	reviewed
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01579	BXGT005770	Interferon gamma	3458	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P01589	BXGT005773	Interleukin-2 receptor subunit alpha	3559	reviewed	Receptor
P02753	BXGT005945	Retinol-binding protein 4	5950	reviewed	Transporter
P02768	BXGT005955	Serum albumin	213	reviewed	Transporter
P03372	BXGT006059	Estrogen receptor	2099	reviewed	Nuclear receptor
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P05107	BXGT006316	Integrin beta-2	3689	reviewed	Receptor
P05362	BXGT006350	Intercellular adhesion molecule 1	3383	reviewed
P07204	BXGT006567	Thrombomodulin	7056	reviewed
P07996	BXGT006710	Thrombospondin-1	7057	reviewed
P08253	BXGT006757	72 kDa type IV collagenase	4313	reviewed	Enzyme
P08254	BXGT006758	Stromelysin-1	4314	reviewed	Enzyme
P09601	BXGT006909	Heme oxygenase 1	3162	reviewed
P09958	BXGT006950	Furin	5045	reviewed	Enzyme
P10145	BXGT007542	Interleukin-8	3576	reviewed	Signaling
P10323	BXGT007557	Acrosin	49	reviewed	Enzyme
P10415	BXGT007567	Apoptosis regulator Bcl-2	596	reviewed	Signaling
P10644	BXGT007597	cAMP-dependent protein kinase type I-alpha regulatory subunit	5573	reviewed
P10646	BXGT007598	Tissue factor pathway inhibitor	7035	reviewed	Enzyme modulator
P11274	BXGT007681	Breakpoint cluster region protein	613	reviewed	Enzyme modulator
P11308	BXGT007684	Transcriptional regulator ERG	2078	reviewed	Transcription factor
P11498	BXGT007714	Pyruvate carboxylase, mitochondrial	5091	reviewed	Enzyme
P11511	BXGT007717	Aromatase	1588	reviewed	Enzyme
P12318	BXGT007799	Low affinity immunoglobulin gamma Fc region receptor II-a	2212	reviewed	Cell adhesion
P12821	BXGT007849	Angiotensin-converting enzyme	1636	reviewed	Enzyme
P14174	BXGT007991	Macrophage migration inhibitory factor	4282	reviewed
P14598	BXGT008024	Neutrophil cytosol factor 1	653361	reviewed
P14780	BXGT008053	Matrix metalloproteinase-9	4318	reviewed	Enzyme
P14902	BXGT008065	Indoleamine 2,3-dioxygenase 1	3620	reviewed
P15941	BXGT008176	Mucin-1	4582	reviewed
P16410	BXGT008224	Cytotoxic T-lymphocyte protein 4	1493	reviewed
P16581	BXGT008245	E-selectin	6401	reviewed
P19320	BXGT008470	Vascular cell adhesion protein 1	7412	reviewed
P21580	BXGT008666	Tumor necrosis factor alpha-induced protein 3	7128	reviewed	Enzyme
P22004	BXGT008718	Bone morphogenetic protein 6	654	reviewed	Signaling
P25103	BXGT009020	Substance-P receptor	6869	reviewed	G-protein coupled receptor
P25774	BXGT009066	Cathepsin S	1520	reviewed	Enzyme
P25963	BXGT009080	NF-kappa-B inhibitor alpha	4792	reviewed
P31645	BXGT009558	Sodium-dependent serotonin transporter	6532	reviewed	Transporter
P40763	BXGT010202	Signal transducer and activator of transcription 3	6774	reviewed	Nucleic acid binding
P41180	BXGT010230	Extracellular calcium-sensing receptor	846	reviewed	G-protein coupled receptor
P42898	BXGT010344	Methylenetetrahydrofolate reductase	4524	reviewed
P48023	BXGT010604	Tumor necrosis factor ligand superfamily member 6	356	reviewed	Signaling
P48061	BXGT010616	Stromal cell-derived factor 1	6387	reviewed
P51449	BXGT010846	Nuclear receptor ROR-gamma	6097	reviewed	Nuclear receptor
P51451	BXGT010848	Tyrosine-protein kinase Blk	640	reviewed	Kinase
P51686	BXGT010881	C-C chemokine receptor type 9	10803	reviewed	G-protein coupled receptor
P55085	BXGT011104	Proteinase-activated receptor 2	2150	reviewed	G-protein coupled receptor
P60568	BXGT011315	Interleukin-2	3558	reviewed
P61626	BXGT011382	Lysozyme C	4069	reviewed
P61769	BXGT011383	Beta-2-microglobulin	567	reviewed	Immune response
P68871	BXGT011615	Hemoglobin subunit beta	3043	reviewed
P69891	BXGT011646	Hemoglobin subunit gamma-1	3047	reviewed
P69892	BXGT011647	Hemoglobin subunit gamma-2	3048	reviewed
P69905	BXGT011649	Hemoglobin subunit alpha	3040	reviewed
P78310	BXGT011830	Coxsackievirus and adenovirus receptor	1525	reviewed
Q01094	BXGT012568	Transcription factor E2F1	1869	reviewed	Nucleic acid binding
Q04760	BXGT012782	Lactoylglutathione lyase	2739	reviewed
Q14994	BXGT013519	Nuclear receptor subfamily 1 group I member 3	9970	reviewed	Nuclear receptor
Q15848	BXGT013609	Adiponectin	9370	reviewed
Q16698	BXGT013659	2,4-dienoyl-CoA reductase, mitochondrial	1666	reviewed	Enzyme
Q7Z7D3	BXGT017262	V-set domain-containing T-cell activation inhibitor 1	79679	reviewed	Enzyme modulator
Q8WWQ0	BXGT019003	PH-interacting protein	55023	reviewed	Epigenetic regulator
Q99558	BXGT019934	Mitogen-activated protein kinase kinase kinase 14	9020	reviewed	Kinase
Q9GZX6	BXGT020428	Interleukin-22	50616	reviewed
Q9HBE5	BXGT020518	Interleukin-21 receptor	50615	reviewed	Receptor
Q9NZM3	BXGT021278	Intersectin-2	50618	reviewed	Enzyme modulator
Q9UHX1	BXGT021707	Poly(U)-binding-splicing factor PUF60	22827	reviewed
Q9UQF0	BXGT021812	Syncytin-1	30816	reviewed
Q9Y251	BXGT022215	Heparanase	10855	reviewed	Enzyme
Q9Y275	BXGT022223	Tumor necrosis factor ligand superfamily member 13B	10673	reviewed
Q9Y5Y6	BXGT022308	Suppressor of tumorigenicity 14 protein	6768	reviewed	Enzyme
P52824	BXGT022672	Diacylglycerol kinase theta	1609	reviewed	Kinase
Q16552	BXGT023419	Interleukin-17A	3605	reviewed

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}