Showing entry for Glaucoma, Primary Open Angle


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD007271
Disease NameGlaucoma, Primary Open Angle
Disease CUI IdC0339573
MeSH Codes C11  
Disease Class NameEye Diseases
Semantic TypeDisease or Syndrome
Human Phenotype Ontology Id HP:0000478  
Human Phenotype Ontology TermAbnormality of the eye
Disease Ontology Id DOID:7  
Disease Ontology Class Namedisease of anatomical entity
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
F7VJQ1 BXGT003310 Alternative prion protein 5621 reviewed
O00206 BXGT003894 Toll-like receptor 4 7099 reviewed
O00212 BXGT003895 Rho-related GTP-binding protein RhoD 29984 reviewed Enzyme modulator
O00311 BXGT003908 Cell division cycle 7-related protein kinase 8317 reviewed Kinase
O00571 BXGT003938 ATP-dependent RNA helicase DDX3X 1654 reviewed
O15075 BXGT004124 Serine/threonine-protein kinase DCLK1 9201 reviewed Kinase
O15123 BXGT004130 Angiopoietin-2 285 reviewed Signaling
O15439 BXGT004169 Multidrug resistance-associated protein 4 10257 reviewed Transporter
O15527 BXGT004176 N-glycosylase/DNA lyase 4968 reviewed
O60313 BXGT004871 Dynamin-like 120 kDa protein, mitochondrial 4976 reviewed Enzyme modulator
O60547 BXGT004881 GDP-mannose 4,6 dehydratase 2762 reviewed Enzyme
O60603 BXGT004887 Toll-like receptor 2 7097 reviewed
O60760 BXGT004899 Hematopoietic prostaglandin D synthase 27306 reviewed
O60895 BXGT004907 Receptor activity-modifying protein 2 10266 reviewed Receptor
O75116 BXGT005100 Rho-associated protein kinase 2 9475 reviewed Kinase
O75369 BXGT005119 Filamin-B 2317 reviewed
O76054 BXGT005172 SEC14-like protein 2 23541 reviewed
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase 8654 reviewed
O95477 BXGT005383 Phospholipid-transporting ATPase ABCA1 19 reviewed Transporter
P00439 BXGT005539 Phenylalanine-4-hydroxylase 5053 reviewed
P00441 BXGT005540 Superoxide dismutase [Cu-Zn] 6647 reviewed Enzyme
P00533 BXGT005575 Epidermal growth factor receptor 1956 reviewed Kinase
P00747 BXGT005639 Plasminogen 5340 reviewed Enzyme
P01011 BXGT005715 Alpha-1-antichymotrypsin 12 reviewed Enzyme modulator
P01024 BXGT005719 Complement C3 718 reviewed Enzyme modulator
P01034 BXGT005721 Cystatin-C 1471 reviewed
P01130 BXGT005735 Low-density lipoprotein receptor 3949 reviewed
P01137 BXGT005737 Transforming growth factor beta-1 proprotein 7040 reviewed Signaling
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01579 BXGT005770 Interferon gamma 3458 reviewed
P01583 BXGT005771 Interleukin-1 alpha 3552 reviewed
P01584 BXGT005772 Interleukin-1 beta 3553 reviewed
P01589 BXGT005773 Interleukin-2 receptor subunit alpha 3559 reviewed Receptor
P01911 BXGT005816 HLA class II histocompatibility antigen, DRB1-15 beta chain 3123 reviewed Immune response
P01920 BXGT005817 HLA class II histocompatibility antigen, DQ beta 1 chain 3119 reviewed Immune response
P02452 BXGT005878 Collagen alpha-1(I) chain 1277 reviewed
P02511 BXGT005885 Alpha-crystallin B chain 1410 reviewed
P02649 BXGT005909 Apolipoprotein E 348 reviewed
P02656 BXGT005913 Apolipoprotein C-III 345 reviewed
P02751 BXGT005943 Fibronectin 2335 reviewed Signaling
P02768 BXGT005955 Serum albumin 213 reviewed Transporter
P03372 BXGT006059 Estrogen receptor 2099 reviewed Nuclear receptor
P03891 BXGT006110 NADH-ubiquinone oxidoreductase chain 2 4536 reviewed
P03956 BXGT006120 Interstitial collagenase 4312 reviewed Enzyme
P04040 BXGT006132 Catalase 847 reviewed Enzyme
P04150 BXGT006154 Glucocorticoid receptor 2908 reviewed Nuclear receptor
P04156 BXGT006156 Major prion protein 5621 reviewed
P04179 BXGT006163 Superoxide dismutase [Mn], mitochondrial 6648 reviewed Enzyme
P04278 BXGT006182 Sex hormone-binding globulin 6462 reviewed
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P04731 BXGT006251 Metallothionein-1A 4489 reviewed
P04732 BXGT006252 Metallothionein-1E 4493 reviewed
P04733 BXGT006253 Metallothionein-1F 4494 reviewed
P04792 BXGT006264 Heat shock protein beta-1 3315 reviewed
P04798 BXGT006265 Cytochrome P450 1A1 1543 reviewed Enzyme
P05067 BXGT006306 Amyloid-beta precursor protein 351 reviewed Enzyme modulator
P05121 BXGT006320 Plasminogen activator inhibitor 1 5054 reviewed Enzyme modulator
P05164 BXGT006333 Myeloperoxidase 4353 reviewed Enzyme
P05231 BXGT006345 Interleukin-6 3569 reviewed
P06756 BXGT006499 Integrin alpha-V 3685 reviewed
P07339 BXGT006604 Cathepsin D 1509 reviewed Enzyme
P07438 BXGT006625 Metallothionein-1B 4490 reviewed
P07550 BXGT006636 Beta-2 adrenergic receptor 154 reviewed G-protein coupled receptor
P07996 BXGT006710 Thrombospondin-1 7057 reviewed
P08183 BXGT006741 ATP-dependent translocase ABCB1 5243 reviewed Transporter
P08253 BXGT006757 72 kDa type IV collagenase 4313 reviewed Enzyme
P08254 BXGT006758 Stromelysin-1 4314 reviewed Enzyme
P08648 BXGT006804 Integrin alpha-5 3678 reviewed
P08758 BXGT006821 Annexin A5 308 reviewed
P08922 BXGT006843 Proto-oncogene tyrosine-protein kinase ROS 6098 reviewed Kinase
P09211 BXGT006869 Glutathione S-transferase P 2950 reviewed
P09455 BXGT006890 Retinol-binding protein 1 5947 reviewed
P09486 BXGT006897 SPARC 6678 reviewed Signaling
P09488 BXGT006899 Glutathione S-transferase Mu 1 2944 reviewed
P09874 BXGT006934 Poly [ADP-ribose] polymerase 1 142 reviewed
P0DMV8 BXGT007509 Heat shock 70 kDa protein 1A 3304 reviewed
P0DMV9 BXGT007510 Heat shock 70 kDa protein 1B 3304 reviewed
P10600 BXGT007584 Transforming growth factor beta-3 proprotein 7043 reviewed Signaling
P10635 BXGT007595 Cytochrome P450 2D6 1565 reviewed
P10809 BXGT007617 60 kDa heat shock protein, mitochondrial 3329 reviewed
P10909 BXGT007630 Clusterin 1191 reviewed
P11021 BXGT007644 Endoplasmic reticulum chaperone BiP 3309 reviewed
P11226 BXGT007675 Mannose-binding protein C 4153 reviewed Receptor
P11473 BXGT007709 Vitamin D3 receptor 7421 reviewed Nuclear receptor
P12821 BXGT007849 Angiotensin-converting enzyme 1636 reviewed Enzyme
P12830 BXGT007852 Cadherin-1 999 reviewed
P13236 BXGT007891 C-C motif chemokine 4 6351 reviewed
P13500 BXGT007916 C-C motif chemokine 2 6347 reviewed Signaling
P13640 BXGT007935 Metallothionein-1G 4495 reviewed
P14780 BXGT008053 Matrix metalloproteinase-9 4318 reviewed Enzyme
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P16278 BXGT008213 Beta-galactosidase 2720 reviewed Enzyme
P16442 BXGT008227 Histo-blood group ABO system transferase 28 reviewed Enzyme
P18146 BXGT008384 Early growth response protein 1 1958 reviewed Nucleic acid binding
P18887 BXGT008437 DNA repair protein XRCC1 7515 reviewed
P19838 BXGT008526 Nuclear factor NF-kappa-B p105 subunit 4790 reviewed Transcription factor
P21980 BXGT008715 Protein-glutamine gamma-glutamyltransferase 2 7052 reviewed Enzyme
P23219 BXGT008837 Prostaglandin G/H synthase 1 5742 reviewed Enzyme
P23560 BXGT008883 Brain-derived neurotrophic factor 627 reviewed Signaling
P25101 BXGT009018 Endothelin-1 receptor 1909 reviewed G-protein coupled receptor
P25942 BXGT009079 Tumor necrosis factor receptor superfamily member 5 958 reviewed
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase 328 reviewed
P28161 BXGT009234 Glutathione S-transferase Mu 2 2946 reviewed
P29474 BXGT009352 Nitric oxide synthase, endothelial 4846 reviewed
P30405 BXGT009423 Peptidyl-prolyl cis-trans isomerase F, mitochondrial 10105 reviewed
P30530 BXGT009431 Tyrosine-protein kinase receptor UFO 558 reviewed Kinase
P30711 BXGT009460 Glutathione S-transferase theta-1 2952 reviewed
P31749 BXGT009574 RAC-alpha serine/threonine-protein kinase 207 reviewed Kinase
P31948 BXGT009590 Stress-induced-phosphoprotein 1 10963 reviewed
P33261 BXGT009707 Cytochrome P450 2C19 1557 reviewed
P34130 BXGT009752 Neurotrophin-4 4909 reviewed Signaling
P34932 BXGT009772 Heat shock 70 kDa protein 4 3308 reviewed
P35228 BXGT009800 Nitric oxide synthase, inducible 4843 reviewed
P35354 BXGT009816 Prostaglandin G/H synthase 2 5743 reviewed Enzyme
P35442 BXGT009832 Thrombospondin-2 7058 reviewed
P35555 BXGT009845 Fibrillin-1 2200 reviewed Calcium-binding protein
P35610 BXGT009855 Sterol O-acyltransferase 1 6646 reviewed Enzyme
P35858 BXGT009876 Insulin-like growth factor-binding protein complex acid labile subunit 3483 reviewed Receptor
P35968 BXGT009887 Vascular endothelial growth factor receptor 2 3791 reviewed Kinase
P38398 BXGT010037 Breast cancer type 1 susceptibility protein 672 reviewed Enzyme
P38936 BXGT010074 Cyclin-dependent kinase inhibitor 1 1026 reviewed
P39060 BXGT010088 Collagen alpha-1(XVIII) chain 80781 reviewed
P39900 BXGT010148 Macrophage metalloelastase 4321 reviewed Enzyme
P40967 BXGT010212 Melanocyte protein PMEL 6490 reviewed Signaling
P41214 BXGT010236 Eukaryotic translation initiation factor 2D 1939 reviewed Receptor
P41279 BXGT010254 Mitogen-activated protein kinase kinase kinase 8 1326 reviewed Kinase
P42898 BXGT010344 Methylenetetrahydrofolate reductase 4524 reviewed
P47712 BXGT010577 Cytosolic phospholipase A2 5321 reviewed Enzyme
P48039 BXGT010607 Melatonin receptor type 1A 4543 reviewed G-protein coupled receptor
P49767 BXGT010739 Vascular endothelial growth factor C 7424 reviewed Signaling
P49888 BXGT010756 Estrogen sulfotransferase 6783 reviewed
P50213 BXGT010779 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 3419 reviewed Enzyme
P50542 BXGT010808 Peroxisomal targeting signal 1 receptor 5830 reviewed Transporter
P50750 BXGT010818 Cyclin-dependent kinase 9 1025 reviewed Kinase
P52789 BXGT010954 Hexokinase-2 3099 reviewed Kinase
P54289 BXGT011040 Voltage-dependent calcium channel subunit alpha-2/delta-1 781 reviewed Ion channel
P54803 BXGT011082 Galactocerebrosidase 2581 reviewed
P60484 BXGT011307 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN 5728 reviewed Enzyme
P60568 BXGT011315 Interleukin-2 3558 reviewed
P60709 BXGT011322 Actin, cytoplasmic 1 60 reviewed Cellular structure
P61586 BXGT011375 Transforming protein RhoA 387 reviewed Enzyme modulator
P62826 BXGT011463 GTP-binding nuclear protein Ran 5901 reviewed Enzyme modulator
P63261 BXGT011512 Actin, cytoplasmic 2 71 reviewed Cellular structure
P80294 BXGT011890 Metallothionein-1H 4496 reviewed
P80297 BXGT011891 Metallothionein-1X 4501 reviewed
Q00653 BXGT012541 Nuclear factor NF-kappa-B p100 subunit 4791 reviewed Transcription factor
Q02108 BXGT012634 Guanylate cyclase soluble subunit alpha-1 2982 reviewed
Q02763 BXGT012667 Angiopoietin-1 receptor 7010 reviewed Kinase
Q03518 BXGT012723 Antigen peptide transporter 1 6890 reviewed Transporter
Q07021 BXGT012915 Complement component 1 Q subcomponent-binding protein, mitochondrial 708 reviewed
Q11130 BXGT013216 Alpha-(1,3)-fucosyltransferase 7 2529 reviewed Enzyme
Q12913 BXGT013279 Receptor-type tyrosine-protein phosphatase eta 5795 reviewed Enzyme
Q13131 BXGT013314 5'-AMP-activated protein kinase catalytic subunit alpha-1 5562 reviewed Kinase
Q13224 BXGT013328 Glutamate receptor ionotropic, NMDA 2B 2904 reviewed Ion channel
Q13233 BXGT013330 Mitogen-activated protein kinase kinase kinase 1 4214 reviewed Kinase
Q13464 BXGT013357 Rho-associated protein kinase 1 6093 reviewed Kinase
Q13625 BXGT013384 Apoptosis-stimulating of p53 protein 2 7159 reviewed Enzyme modulator
Q13936 BXGT013404 Voltage-dependent L-type calcium channel subunit alpha-1C 775 reviewed Ion channel
Q14469 BXGT013473 Transcription factor HES-1 3280 reviewed Transcription factor
Q14573 BXGT013486 Inositol 1,4,5-trisphosphate receptor type 3 3710 reviewed Ion channel
Q14624 BXGT013491 Inter-alpha-trypsin inhibitor heavy chain H4 3700 reviewed Enzyme modulator
Q15020 BXGT013522 Squamous cell carcinoma antigen recognized by T-cells 3 9733 reviewed Nucleic acid binding
Q15109 BXGT013537 Advanced glycosylation end product-specific receptor 177 reviewed Receptor
Q16611 BXGT013644 Bcl-2 homologous antagonist/killer 578 reviewed Signaling
Q16678 BXGT013656 Cytochrome P450 1B1 1545 reviewed Enzyme
Q5Y7D3 BXGT015912 HLA class II histocompatibility antigen DQ beta chain 3119 unreviewed
Q6P2Q9 BXGT016446 Pre-mRNA-processing-splicing factor 8 10594 reviewed Nucleic acid binding
Q7KZF4 BXGT016989 Staphylococcal nuclease domain-containing protein 1 27044 reviewed Transcription factor
Q8N339 BXGT018503 Metallothionein-1M 4499 reviewed
Q8WY64 BXGT019017 E3 ubiquitin-protein ligase MYLIP 29116 reviewed
Q92731 BXGT019366 Estrogen receptor beta 2100 reviewed Nuclear receptor
Q96AZ6 BXGT019621 Interferon-stimulated gene 20 kDa protein 3669 reviewed
Q96EB6 BXGT019646 NAD-dependent protein deacetylase sirtuin-1 23411 reviewed Epigenetic regulator
Q99700 BXGT019949 Ataxin-2 6311 reviewed Nucleic acid binding
Q99972 BXGT019979 Myocilin 4653 reviewed Cellular structure
Q9NNW7 BXGT021139 Thioredoxin reductase 2, mitochondrial 10587 reviewed Enzyme
Q9UBN7 BXGT021658 Histone deacetylase 6 10013 reviewed Epigenetic regulator
Q9UHD2 BXGT021697 Serine/threonine-protein kinase TBK1 29110 reviewed Kinase
Q9UIF7 BXGT021717 Adenine DNA glycosylase 4595 reviewed Enzyme
Q9ULW0 BXGT021766 Targeting protein for Xklp2 22974 reviewed Cellular structure
Q9Y2J8 BXGT022237 Protein-arginine deiminase type-2 11240 reviewed
Q9Y2Q3 BXGT022242 Glutathione S-transferase kappa 1 373156 reviewed
Q9Y4K0 BXGT022280 Lysyl oxidase homolog 2 4017 reviewed
Q9Y6A2 BXGT022324 Cholesterol 24-hydroxylase 10858 reviewed Enzyme
P04439 BXGT022649 HLA class I histocompatibility antigen, A-3 alpha chain 3105 reviewed
Q9NYP7 BXGT022661 Elongation of very long chain fatty acids protein 5 60481 reviewed Enzyme
Q96KN7 BXGT022801 X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 57096 reviewed Enzyme modulator
O15467 BXGT023188 C-C motif chemokine 16 6360 reviewed Signaling
P00395 BXGT023596 Cytochrome c oxidase subunit 1 4512 reviewed Enzyme
Q9P121 BXGT025711 Neurotrimin 50863 reviewed
P00403 BXGT026137 Cytochrome c oxidase subunit 2 4513 reviewed Enzyme
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease