adisease

Showing entry for airway disease

General Disease Information
BXGD Id	BXGD009872
Disease Name	airway disease
Disease CUI Id	C0699949
MeSH Codes	C23 C08
Disease Class Name	Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id
Human Phenotype Ontology Term
Disease Ontology Id
Disease Ontology Class Name
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00206	BXGT003894	Toll-like receptor 4	7099	reviewed
O14842	BXGT004106	Free fatty acid receptor 1	2864	reviewed	G-protein coupled receptor
O15264	BXGT004144	Mitogen-activated protein kinase 13	5603	reviewed	Kinase
O43570	BXGT004601	Carbonic anhydrase 12	771	reviewed
O43914	BXGT004635	TYRO protein tyrosine kinase-binding protein	7305	reviewed
O76074	BXGT005174	cGMP-specific 3',5'-cyclic phosphodiesterase	8654	reviewed
P00441	BXGT005540	Superoxide dismutase [Cu-Zn]	6647	reviewed	Enzyme
P00533	BXGT005575	Epidermal growth factor receptor	1956	reviewed	Kinase
P01024	BXGT005719	Complement C3	718	reviewed	Enzyme modulator
P01133	BXGT005736	Pro-epidermal growth factor	1950	reviewed
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01138	BXGT005738	Beta-nerve growth factor	4803	reviewed	Signaling
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01579	BXGT005770	Interferon gamma	3458	reviewed
P01583	BXGT005771	Interleukin-1 alpha	3552	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P01589	BXGT005773	Interleukin-2 receptor subunit alpha	3559	reviewed	Receptor
P01911	BXGT005816	HLA class II histocompatibility antigen, DRB1-15 beta chain	3123	reviewed	Immune response
P01920	BXGT005817	HLA class II histocompatibility antigen, DQ beta 1 chain	3119	reviewed	Immune response
P02649	BXGT005909	Apolipoprotein E	348	reviewed
P03956	BXGT006120	Interstitial collagenase	4312	reviewed	Enzyme
P05107	BXGT006316	Integrin beta-2	3689	reviewed	Receptor
P05231	BXGT006345	Interleukin-6	3569	reviewed
P05362	BXGT006350	Intercellular adhesion molecule 1	3383	reviewed
P05771	BXGT006384	Protein kinase C beta type	5579	reviewed	Kinase
P07550	BXGT006636	Beta-2 adrenergic receptor	154	reviewed	G-protein coupled receptor
P07900	BXGT006696	Heat shock protein HSP 90-alpha	3320	reviewed	Chaperone
P08069	BXGT006723	Insulin-like growth factor 1 receptor	3480	reviewed	Kinase
P08588	BXGT006795	Beta-1 adrenergic receptor	153	reviewed	G-protein coupled receptor
P09382	BXGT006882	Galectin-1	3956	reviewed	Signaling
P09429	BXGT006889	High mobility group protein B1	3146	reviewed	Nucleic acid binding
P10145	BXGT007542	Interleukin-8	3576	reviewed	Signaling
P10747	BXGT007609	T-cell-specific surface glycoprotein CD28	940	reviewed
P11215	BXGT007672	Integrin alpha-M	3684	reviewed
P12004	BXGT007766	Proliferating cell nuclear antigen	5111	reviewed	Nucleic acid binding
P12724	BXGT007837	Eosinophil cationic protein	6037	reviewed
P13500	BXGT007916	C-C motif chemokine 2	6347	reviewed	Signaling
P13569	BXGT007923	Cystic fibrosis transmembrane conductance regulator	1080	reviewed	Ion channel
P13612	BXGT007928	Integrin alpha-4	3676	reviewed
P14784	BXGT008054	Interleukin-2 receptor subunit beta	3560	reviewed	Receptor
P15121	BXGT008083	Aldo-keto reductase family 1 member B1	231	reviewed	Enzyme
P15311	BXGT008106	Ezrin	7430	reviewed	Cellular structure
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P15813	BXGT008158	Antigen-presenting glycoprotein CD1d	912	reviewed
P16671	BXGT008255	Platelet glycoprotein 4	948	reviewed	Receptor
P17252	BXGT008294	Protein kinase C alpha type	5578	reviewed	Kinase
P18847	BXGT008431	Cyclic AMP-dependent transcription factor ATF-3	467	reviewed	Transcription factor
P18850	BXGT008433	Cyclic AMP-dependent transcription factor ATF-6 alpha	22926	reviewed
P19113	BXGT008458	Histidine decarboxylase	3067	reviewed
P19429	BXGT008479	Troponin I, cardiac muscle	7137	reviewed	Cellular structure
P20702	BXGT008592	Integrin alpha-X	3687	reviewed
P20930	BXGT008616	Filaggrin	2312	reviewed	Cellular structure
P21579	BXGT008665	Synaptotagmin-1	6857	reviewed	Transporter
P22455	BXGT008772	Fibroblast growth factor receptor 4	2264	reviewed	Kinase
P23458	BXGT008868	Tyrosine-protein kinase JAK1	3716	reviewed	Kinase
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P25025	BXGT009006	C-X-C chemokine receptor type 2	3579	reviewed	G-protein coupled receptor
P25105	BXGT009021	Platelet-activating factor receptor	5724	reviewed	G-protein coupled receptor
P27815	BXGT009208	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	5141	reviewed
P28562	BXGT009270	Dual specificity protein phosphatase 1	1843	reviewed
P28907	BXGT009301	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	952	reviewed	Enzyme
P32418	BXGT009635	Sodium/calcium exchanger 1	6546	reviewed	Transporter
P32929	BXGT009682	Cystathionine gamma-lyase	1491	reviewed	Enzyme
P35222	BXGT009799	Catenin beta-1	1499	reviewed
P35247	BXGT009804	Pulmonary surfactant-associated protein D	6441	reviewed	Surfactant
P35354	BXGT009816	Prostaglandin G/H synthase 2	5743	reviewed	Enzyme
P35367	BXGT009821	Histamine H1 receptor	3269	reviewed	G-protein coupled receptor
P35869	BXGT009877	Aryl hydrocarbon receptor	196	reviewed	Transcription factor
P36222	BXGT009914	Chitinase-3-like protein 1	1116	reviewed
P37231	BXGT009972	Peroxisome proliferator-activated receptor gamma	5468	reviewed	Nuclear receptor
P40763	BXGT010202	Signal transducer and activator of transcription 3	6774	reviewed	Nucleic acid binding
P40933	BXGT010209	Interleukin-15	3600	reviewed
P42226	BXGT010288	Signal transducer and activator of transcription 6	6778	reviewed	Nucleic acid binding
P49137	BXGT010680	MAP kinase-activated protein kinase 2	9261	reviewed	Kinase
P51677	BXGT010876	C-C chemokine receptor type 3	1232	reviewed	G-protein coupled receptor
P51692	BXGT010885	Signal transducer and activator of transcription 5B	6777	reviewed	Nucleic acid binding
P54707	BXGT011068	Potassium-transporting ATPase alpha chain 2	479	reviewed	Transporter
P55085	BXGT011104	Proteinase-activated receptor 2	2150	reviewed	G-protein coupled receptor
P60568	BXGT011315	Interleukin-2	3558	reviewed
P60709	BXGT011322	Actin, cytoplasmic 1	60	reviewed	Cellular structure
P61073	BXGT011352	C-X-C chemokine receptor type 4	7852	reviewed	G-protein coupled receptor
P84022	BXGT012027	Mothers against decapentaplegic homolog 3	4088	reviewed	Transcription factor
Q04206	BXGT012754	Transcription factor p65	5970	reviewed	Transcription factor
Q04721	BXGT012777	Neurogenic locus notch homolog protein 2	4853	reviewed
Q12778	BXGT013263	Forkhead box protein O1	2308	reviewed
Q13478	BXGT013362	Interleukin-18 receptor 1	8809	reviewed	Receptor
Q14011	BXGT013436	Cold-inducible RNA-binding protein	1153	reviewed	Nucleic acid binding
Q14116	BXGT013442	Interleukin-18	3606	reviewed
Q14627	BXGT013492	Interleukin-13 receptor subunit alpha-2	3598	reviewed	Signaling
Q15063	BXGT013531	Periostin	10631	reviewed	Signaling
Q15257	BXGT013554	Serine/threonine-protein phosphatase 2A activator	5524	reviewed	Enzyme modulator
Q16236	BXGT013624	Nuclear factor erythroid 2-related factor 2	4780	reviewed	Enzyme
Q460N5	BXGT014635	Protein mono-ADP-ribosyltransferase PARP14	54625	reviewed
Q5Y7D3	BXGT015912	HLA class II histocompatibility antigen DQ beta chain	3119	unreviewed
Q6P589	BXGT016452	Tumor necrosis factor alpha-induced protein 8-like protein 2	79626	reviewed
Q76MJ5	BXGT016871	Serine/threonine-protein kinase/endoribonuclease IRE2	10595	reviewed	Kinase
Q8N3J5	BXGT018506	Protein phosphatase 1K, mitochondrial	152926	reviewed	Enzyme
Q8NER1	BXGT018556	Transient receptor potential cation channel subfamily V member 1	7442	reviewed	Ion channel
Q92769	BXGT019370	Histone deacetylase 2	3066	reviewed	Epigenetic regulator
Q96AZ6	BXGT019621	Interferon-stimulated gene 20 kDa protein	3669	reviewed
Q96P20	BXGT019704	NACHT, LRR and PYD domains-containing protein 3	114548	reviewed
Q96PD4	BXGT019705	Interleukin-17F	112744	reviewed
Q99581	BXGT019937	Protein FEV	54738	reviewed	Transcription factor
Q9BZP6	BXGT020201	Acidic mammalian chitinase	27159	reviewed
Q9BZS1	BXGT020203	Forkhead box protein P3	50943	reviewed
Q9GZX6	BXGT020428	Interleukin-22	50616	reviewed
Q9H244	BXGT020448	P2Y purinoceptor 12	64805	reviewed	G-protein coupled receptor
Q9H4A3	BXGT020473	Serine/threonine-protein kinase WNK1	65125	reviewed	Kinase
Q9HBX9	BXGT020523	Relaxin receptor 1	59350	reviewed	G-protein coupled receptor
Q9NP55	BXGT021141	BPI fold-containing family A member 1	51297	reviewed
Q9NP99	BXGT021148	Triggering receptor expressed on myeloid cells 1	54210	reviewed
Q9UKV0	BXGT021750	Histone deacetylase 9	9734	reviewed	Epigenetic regulator
Q9Y271	BXGT022222	Cysteinyl leukotriene receptor 1	10800	reviewed	G-protein coupled receptor
Q16552	BXGT023419	Interleukin-17A	3605	reviewed
Q9BQQ3	BXGT024065	Golgi reassembly-stacking protein 1	64689	reviewed
A8K7I4	BXGT025277	Calcium-activated chloride channel regulator 1	1179	reviewed	Ion channel
Q969H8	BXGT025606	Myeloid-derived growth factor	56005	reviewed
Q7LBE3	BXGT026071	Solute carrier family 26 member 9	115019	reviewed	Transporter
P00403	BXGT026137	Cytochrome c oxidase subunit 2	4513	reviewed	Enzyme

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}