Showing entry for Sjogren's Syndrome


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD013271
Disease NameSjogren's Syndrome
Disease CUI IdC1527336
MeSH Codes C11   C17   C05   C20   C07  
Disease Class NameEye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
Semantic TypeDisease or Syndrome
Human Phenotype Ontology Id   
Human Phenotype Ontology Term
Disease Ontology Id DOID:7  
Disease Ontology Class Namedisease of anatomical entity
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
O00329 BXGT003909 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 5293 reviewed Kinase
O14733 BXGT004087 Dual specificity mitogen-activated protein kinase kinase 7 5609 reviewed Kinase
O14786 BXGT004099 Neuropilin-1 8829 reviewed
O14931 BXGT004113 Natural cytotoxicity triggering receptor 3 259197 reviewed
O15245 BXGT004141 Solute carrier family 22 member 1 6580 reviewed Transporter
O43557 BXGT004600 Tumor necrosis factor ligand superfamily member 14 8740 reviewed Signaling
O75369 BXGT005119 Filamin-B 2317 reviewed
O76054 BXGT005172 SEC14-like protein 2 23541 reviewed
O94759 BXGT005327 Transient receptor potential cation channel subfamily M member 2 7226 reviewed Ion channel
O94811 BXGT005336 Tubulin polymerization-promoting protein 11076 reviewed Cellular structure
O95477 BXGT005383 Phospholipid-transporting ATPase ABCA1 19 reviewed Transporter
O95716 BXGT005391 Ras-related protein Rab-3D 9545 reviewed
O95786 BXGT005396 Probable ATP-dependent RNA helicase DDX58 23586 reviewed
P00450 BXGT005544 Ceruloplasmin 1356 reviewed Enzyme
P00505 BXGT005560 Aspartate aminotransferase, mitochondrial 2806 reviewed
P00533 BXGT005575 Epidermal growth factor receptor 1956 reviewed Kinase
P00740 BXGT005634 Coagulation factor IX 2158 reviewed Enzyme
P00813 BXGT005667 Adenosine deaminase 100 reviewed Enzyme
P00915 BXGT005689 Carbonic anhydrase 1 759 reviewed
P00918 BXGT005690 Carbonic anhydrase 2 760 reviewed
P00973 BXGT005711 2'-5'-oligoadenylate synthase 1 4938 reviewed Enzyme
P01009 BXGT005714 Alpha-1-antitrypsin 5265 reviewed Enzyme modulator
P01024 BXGT005719 Complement C3 718 reviewed Enzyme modulator
P01034 BXGT005721 Cystatin-C 1471 reviewed
P01106 BXGT005730 Myc proto-oncogene protein 4609 reviewed Transcription factor
P01133 BXGT005736 Pro-epidermal growth factor 1950 reviewed
P01137 BXGT005737 Transforming growth factor beta-1 proprotein 7040 reviewed Signaling
P01138 BXGT005738 Beta-nerve growth factor 4803 reviewed Signaling
P01236 BXGT005744 Prolactin 5617 reviewed Signaling
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01574 BXGT005768 Interferon beta 3456 reviewed
P01579 BXGT005770 Interferon gamma 3458 reviewed
P01583 BXGT005771 Interleukin-1 alpha 3552 reviewed
P01584 BXGT005772 Interleukin-1 beta 3553 reviewed
P01589 BXGT005773 Interleukin-2 receptor subunit alpha 3559 reviewed Receptor
P01730 BXGT005781 T-cell surface glycoprotein CD4 920 reviewed
P01732 BXGT005782 T-cell surface glycoprotein CD8 alpha chain 925 reviewed
P01889 BXGT005809 HLA class I histocompatibility antigen, B-7 alpha chain 3106 reviewed
P01903 BXGT005814 HLA class II histocompatibility antigen, DR alpha chain 3122 reviewed Immune response
P01909 BXGT005815 HLA class II histocompatibility antigen, DQ alpha 1 chain 3117 reviewed Immune response
P01911 BXGT005816 HLA class II histocompatibility antigen, DRB1-15 beta chain 3123 reviewed Immune response
P02741 BXGT005936 C-reactive protein 1401 reviewed
P02749 BXGT005941 Beta-2-glycoprotein 1 350 reviewed
P02766 BXGT005953 Transthyretin 7276 reviewed Transporter
P02768 BXGT005955 Serum albumin 213 reviewed Transporter
P02775 BXGT005960 Platelet basic protein 5473 reviewed Signaling
P02788 BXGT005963 Lactotransferrin 4057 reviewed Enzyme
P03372 BXGT006059 Estrogen receptor 2099 reviewed Nuclear receptor
P04066 BXGT006142 Tissue alpha-L-fucosidase 2517 reviewed
P04150 BXGT006154 Glucocorticoid receptor 2908 reviewed Nuclear receptor
P04440 BXGT006216 HLA class II histocompatibility antigen, DP beta 1 chain 3115 reviewed Immune response
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P04745 BXGT006255 Alpha-amylase 1 278 reviewed
P04798 BXGT006265 Cytochrome P450 1A1 1543 reviewed Enzyme
P05107 BXGT006316 Integrin beta-2 3689 reviewed Receptor
P05109 BXGT006318 Protein S100-A8 6279 reviewed Calcium-binding protein
P05164 BXGT006333 Myeloperoxidase 4353 reviewed Enzyme
P05187 BXGT006339 Alkaline phosphatase, placental type 250 reviewed Enzyme
P05231 BXGT006345 Interleukin-6 3569 reviewed
P05362 BXGT006350 Intercellular adhesion molecule 1 3383 reviewed
P06396 BXGT006435 Gelsolin 2934 reviewed Cellular structure
P06702 BXGT006476 Protein S100-A9 6280 reviewed Calcium-binding protein
P06729 BXGT006486 T-cell surface antigen CD2 914 reviewed
P06858 BXGT006515 Lipoprotein lipase 4023 reviewed Enzyme
P07339 BXGT006604 Cathepsin D 1509 reviewed Enzyme
P07858 BXGT006689 Cathepsin B 1508 reviewed Enzyme
P07996 BXGT006710 Thrombospondin-1 7057 reviewed
P08253 BXGT006757 72 kDa type IV collagenase 4313 reviewed Enzyme
P08254 BXGT006758 Stromelysin-1 4314 reviewed Enzyme
P08842 BXGT006830 Steryl-sulfatase 412 reviewed Enzyme
P08887 BXGT006835 Interleukin-6 receptor subunit alpha 3570 reviewed Signaling
P09429 BXGT006889 High mobility group protein B1 3146 reviewed Nucleic acid binding
P09466 BXGT006892 Glycodelin 5047 reviewed Enzyme
P09488 BXGT006899 Glutathione S-transferase Mu 1 2944 reviewed
P09601 BXGT006909 Heme oxygenase 1 3162 reviewed
P10145 BXGT007542 Interleukin-8 3576 reviewed Signaling
P10323 BXGT007557 Acrosin 49 reviewed Enzyme
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P10599 BXGT007583 Thioredoxin 7295 reviewed
P11226 BXGT007675 Mannose-binding protein C 4153 reviewed Receptor
P11473 BXGT007709 Vitamin D3 receptor 7421 reviewed Nuclear receptor
P11511 BXGT007717 Aromatase 1588 reviewed Enzyme
P12318 BXGT007799 Low affinity immunoglobulin gamma Fc region receptor II-a 2212 reviewed Cell adhesion
P13501 BXGT007917 C-C motif chemokine 5 6352 reviewed Signaling
P13569 BXGT007923 Cystic fibrosis transmembrane conductance regulator 1080 reviewed Ion channel
P14598 BXGT008024 Neutrophil cytosol factor 1 653361 reviewed
P14616 BXGT008026 Insulin receptor-related protein 3645 reviewed Kinase
P14780 BXGT008053 Matrix metalloproteinase-9 4318 reviewed Enzyme
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P15941 BXGT008176 Mucin-1 4582 reviewed
P16070 BXGT008186 CD44 antigen 960 reviewed
P16410 BXGT008224 Cytotoxic T-lymphocyte protein 4 1493 reviewed
P16581 BXGT008245 E-selectin 6401 reviewed
P16871 BXGT008269 Interleukin-7 receptor subunit alpha 3575 reviewed Receptor
P17706 BXGT008330 Tyrosine-protein phosphatase non-receptor type 2 5771 reviewed
P17861 BXGT008348 X-box-binding protein 1 7494 reviewed
P18850 BXGT008433 Cyclic AMP-dependent transcription factor ATF-6 alpha 22926 reviewed
P19320 BXGT008470 Vascular cell adhesion protein 1 7412 reviewed
P19438 BXGT008480 Tumor necrosis factor receptor superfamily member 1A 7132 reviewed
P19525 BXGT008492 Interferon-induced, double-stranded RNA-activated protein kinase 5610 reviewed Kinase
P19838 BXGT008526 Nuclear factor NF-kappa-B p105 subunit 4790 reviewed Transcription factor
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 1131 reviewed G-protein coupled receptor
P20338 BXGT008564 Ras-related protein Rab-4A 5867 reviewed
P20701 BXGT008591 Integrin alpha-L 3683 reviewed
P20810 BXGT008602 Calpastatin 831 reviewed
P21579 BXGT008665 Synaptotagmin-1 6857 reviewed Transporter
P21580 BXGT008666 Tumor necrosis factor alpha-induced protein 3 7128 reviewed Enzyme
P22004 BXGT008718 Bone morphogenetic protein 6 654 reviewed Signaling
P23280 BXGT008844 Carbonic anhydrase 6 765 reviewed
P23560 BXGT008883 Brain-derived neurotrophic factor 627 reviewed Signaling
P24158 BXGT008951 Myeloblastin 5657 reviewed Enzyme
P24298 BXGT008960 Alanine aminotransferase 1 2875 reviewed Enzyme
P24855 BXGT008998 Deoxyribonuclease-1 1773 reviewed
P25024 BXGT009005 C-X-C chemokine receptor type 1 3577 reviewed G-protein coupled receptor
P25025 BXGT009006 C-X-C chemokine receptor type 2 3579 reviewed G-protein coupled receptor
P25101 BXGT009018 Endothelin-1 receptor 1909 reviewed G-protein coupled receptor
P25774 BXGT009066 Cathepsin S 1520 reviewed Enzyme
P25942 BXGT009079 Tumor necrosis factor receptor superfamily member 5 958 reviewed
P25963 BXGT009080 NF-kappa-B inhibitor alpha 4792 reviewed
P27797 BXGT009206 Calreticulin 811 reviewed Calcium-binding protein
P28161 BXGT009234 Glutathione S-transferase Mu 2 2946 reviewed
P28482 BXGT009263 Mitogen-activated protein kinase 1 5594 reviewed Kinase
P28908 BXGT009302 Tumor necrosis factor receptor superfamily member 8 943 reviewed
P29323 BXGT009334 Ephrin type-B receptor 2 2048 reviewed Kinase
P29466 BXGT009349 Caspase-1 834 reviewed Enzyme
P29965 BXGT009388 CD40 ligand 959 reviewed Signaling
P30536 BXGT009435 Translocator protein 706 reviewed
P30559 BXGT009442 Oxytocin receptor 5021 reviewed G-protein coupled receptor
P30711 BXGT009460 Glutathione S-transferase theta-1 2952 reviewed
P31025 BXGT009500 Lipocalin-1 3933 reviewed Enzyme
P32302 BXGT009619 C-X-C chemokine receptor type 5 643 reviewed G-protein coupled receptor
P34932 BXGT009772 Heat shock 70 kDa protein 4 3308 reviewed
P35610 BXGT009855 Sterol O-acyltransferase 1 6646 reviewed Enzyme
P35968 BXGT009887 Vascular endothelial growth factor receptor 2 3791 reviewed Kinase
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma 5468 reviewed Nuclear receptor
P40763 BXGT010202 Signal transducer and activator of transcription 3 6774 reviewed Nucleic acid binding
P41182 BXGT010231 B-cell lymphoma 6 protein 604 reviewed
P42224 BXGT010286 Signal transducer and activator of transcription 1-alpha/beta 6772 reviewed Nucleic acid binding
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 5290 reviewed Kinase
P42338 BXGT010303 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 5291 reviewed Kinase
P42345 BXGT010304 Serine/threonine-protein kinase mTOR 2475 reviewed Kinase
P42574 BXGT010317 Caspase-3 836 reviewed Enzyme
P43354 BXGT010381 Nuclear receptor subfamily 4 group A member 2 4929 reviewed Nuclear receptor
P45983 BXGT010494 Mitogen-activated protein kinase 8 5599 reviewed Kinase
P47989 BXGT010602 Xanthine dehydrogenase/oxidase 7498 reviewed Enzyme
P48023 BXGT010604 Tumor necrosis factor ligand superfamily member 6 356 reviewed Signaling
P48061 BXGT010616 Stromal cell-derived factor 1 6387 reviewed
P48357 BXGT010627 Leptin receptor 3953 reviewed Signaling
P48736 BXGT010658 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 5294 reviewed Kinase
P51449 BXGT010846 Nuclear receptor ROR-gamma 6097 reviewed Nuclear receptor
P51451 BXGT010848 Tyrosine-protein kinase Blk 640 reviewed Kinase
P51580 BXGT010864 Thiopurine S-methyltransferase 7172 reviewed
P51617 BXGT010868 Interleukin-1 receptor-associated kinase 1 3654 reviewed Kinase
P51686 BXGT010881 C-C chemokine receptor type 9 10803 reviewed G-protein coupled receptor
P52758 BXGT010951 2-iminobutanoate/2-iminopropanoate deaminase 10247 reviewed
P54646 BXGT011062 5'-AMP-activated protein kinase catalytic subunit alpha-2 5563 reviewed Kinase
P55087 BXGT011105 Aquaporin-4 361 reviewed Ion channel
P55774 BXGT011124 C-C motif chemokine 18 6362 reviewed Signaling
P60484 BXGT011307 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN 5728 reviewed Enzyme
P60568 BXGT011315 Interleukin-2 3558 reviewed
P60981 BXGT011344 Destrin 11034 reviewed
P61073 BXGT011352 C-X-C chemokine receptor type 4 7852 reviewed G-protein coupled receptor
P61626 BXGT011382 Lysozyme C 4069 reviewed
P78330 BXGT011833 Phosphoserine phosphatase 5723 reviewed Enzyme
P78536 BXGT011847 Disintegrin and metalloproteinase domain-containing protein 17 6868 reviewed
Q01082 BXGT012567 Spectrin beta chain, non-erythrocytic 1 6711 reviewed
Q01094 BXGT012568 Transcription factor E2F1 1869 reviewed Nucleic acid binding
Q03518 BXGT012723 Antigen peptide transporter 1 6890 reviewed Transporter
Q04206 BXGT012754 Transcription factor p65 5970 reviewed Transcription factor
Q06187 BXGT012860 Tyrosine-protein kinase BTK 695 reviewed Kinase
Q06787 BXGT012890 Synaptic functional regulator FMR1 2332 reviewed Nucleic acid binding
Q07011 BXGT012912 Tumor necrosis factor receptor superfamily member 9 3604 reviewed
Q07108 BXGT012919 Early activation antigen CD69 969 reviewed
Q07812 BXGT012940 Apoptosis regulator BAX 581 reviewed Signaling
Q07869 BXGT012945 Peroxisome proliferator-activated receptor alpha 5465 reviewed Nuclear receptor
Q08945 BXGT013014 FACT complex subunit SSRP1 6749 reviewed
Q09028 BXGT013025 Histone-binding protein RBBP4 5928 reviewed
Q12879 BXGT013275 Glutamate receptor ionotropic, NMDA 2A 2903 reviewed Ion channel
Q13131 BXGT013314 5'-AMP-activated protein kinase catalytic subunit alpha-1 5562 reviewed Kinase
Q13478 BXGT013362 Interleukin-18 receptor 1 8809 reviewed Receptor
Q13586 BXGT013380 Stromal interaction molecule 1 6786 reviewed
Q14116 BXGT013442 Interleukin-18 3606 reviewed
Q14164 BXGT013451 Inhibitor of nuclear factor kappa-B kinase subunit epsilon 9641 reviewed Kinase
Q14573 BXGT013486 Inositol 1,4,5-trisphosphate receptor type 3 3710 reviewed Ion channel
Q14643 BXGT013493 Inositol 1,4,5-trisphosphate receptor type 1 3708 reviewed Ion channel
Q14994 BXGT013519 Nuclear receptor subfamily 1 group I member 3 9970 reviewed Nuclear receptor
Q15109 BXGT013537 Advanced glycosylation end product-specific receptor 177 reviewed Receptor
Q15116 BXGT013539 Programmed cell death protein 1 5133 reviewed
Q15848 BXGT013609 Adiponectin 9370 reviewed
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha 3091 reviewed Transcription factor
Q16666 BXGT013654 Gamma-interferon-inducible protein 16 3428 reviewed Transcription factor
Q5VWK5 BXGT015891 Interleukin-23 receptor 149233 reviewed Signaling
Q6N021 BXGT016378 Methylcytosine dioxygenase TET2 54790 reviewed
Q7L266 BXGT016993 Isoaspartyl peptidase/L-asparaginase 80150 reviewed Enzyme
Q8IU57 BXGT018332 Interferon lambda receptor 1 163702 reviewed Receptor
Q8NER1 BXGT018556 Transient receptor potential cation channel subfamily V member 1 7442 reviewed Ion channel
Q8NFP7 BXGT018562 Diphosphoinositol polyphosphate phosphohydrolase 3-alpha 170685 reviewed Enzyme
Q8WWQ0 BXGT019003 PH-interacting protein 55023 reviewed Epigenetic regulator
Q96AZ6 BXGT019621 Interferon-stimulated gene 20 kDa protein 3669 reviewed
Q96E93 BXGT019645 Killer cell lectin-like receptor subfamily G member 1 10219 reviewed
Q96EQ8 BXGT019652 E3 ubiquitin-protein ligase RNF125 54941 reviewed
Q96P20 BXGT019704 NACHT, LRR and PYD domains-containing protein 3 114548 reviewed
Q96PD4 BXGT019705 Interleukin-17F 112744 reviewed
Q96RJ3 BXGT019729 Tumor necrosis factor receptor superfamily member 13C 115650 reviewed
Q99558 BXGT019934 Mitogen-activated protein kinase kinase kinase 14 9020 reviewed Kinase
Q99572 BXGT019935 P2X purinoceptor 7 5027 reviewed Ion channel
Q99653 BXGT019945 Calcineurin B homologous protein 1 11261 reviewed
Q99836 BXGT019970 Myeloid differentiation primary response protein MyD88 4615 reviewed Enzyme modulator
Q9BTY2 BXGT020128 Plasma alpha-L-fucosidase 2519 reviewed
Q9BY64 BXGT020182 UDP-glucuronosyltransferase 2B28 54490 reviewed
Q9BZP6 BXGT020201 Acidic mammalian chitinase 27159 reviewed
Q9BZS1 BXGT020203 Forkhead box protein P3 50943 reviewed
Q9GZX6 BXGT020428 Interleukin-22 50616 reviewed
Q9H0A0 BXGT020434 RNA cytidine acetyltransferase 55226 reviewed
Q9H4A3 BXGT020473 Serine/threonine-protein kinase WNK1 65125 reviewed Kinase
Q9NV35 BXGT021222 Nucleotide triphosphate diphosphatase NUDT15 55270 reviewed
Q9NYK1 BXGT021258 Toll-like receptor 7 51284 reviewed
Q9NZM3 BXGT021278 Intersectin-2 50618 reviewed Enzyme modulator
Q9NZQ7 BXGT021281 Programmed cell death 1 ligand 1 29126 reviewed Receptor
Q9UDY8 BXGT021670 Mucosa-associated lymphoid tissue lymphoma translocation protein 1 10892 reviewed Enzyme
Q9UH17 BXGT021691 DNA dC->dU-editing enzyme APOBEC-3B 9582 reviewed Enzyme
Q9UHD2 BXGT021697 Serine/threonine-protein kinase TBK1 29110 reviewed Kinase
Q9UHX1 BXGT021707 Poly(U)-binding-splicing factor PUF60 22827 reviewed
Q9UJU2 BXGT021730 Lymphoid enhancer-binding factor 1 51176 reviewed
Q9UKU7 BXGT021749 Isobutyryl-CoA dehydrogenase, mitochondrial 27034 reviewed Enzyme
Q9UM07 BXGT021771 Protein-arginine deiminase type-4 23569 reviewed
Q9UNQ0 BXGT021792 ATP-binding cassette sub-family G member 2 9429 reviewed Transporter
Q9Y239 BXGT022213 Nucleotide-binding oligomerization domain-containing protein 1 10392 reviewed Enzyme
Q9Y243 BXGT022214 RAC-gamma serine/threonine-protein kinase 10000 reviewed Kinase
Q9Y275 BXGT022223 Tumor necrosis factor ligand superfamily member 13B 10673 reviewed
Q9Y3B4 BXGT022255 Splicing factor 3B subunit 6 51639 reviewed
Q9Y478 BXGT022271 5'-AMP-activated protein kinase subunit beta-1 5564 reviewed Kinase
Q9Y5L0 BXGT022296 Transportin-3 23534 reviewed Transporter
Q9Y5Y6 BXGT022308 Suppressor of tumorigenicity 14 protein 6768 reviewed Enzyme
P04439 BXGT022649 HLA class I histocompatibility antigen, A-3 alpha chain 3105 reviewed
P52824 BXGT022672 Diacylglycerol kinase theta 1609 reviewed Kinase
Q92482 BXGT022676 Aquaporin-3 360 reviewed Ion channel
Q9GZQ8 BXGT023414 Microtubule-associated proteins 1A/1B light chain 3B 81631 reviewed Cellular structure
Q16552 BXGT023419 Interleukin-17A 3605 reviewed
Q9BQQ3 BXGT024065 Golgi reassembly-stacking protein 1 64689 reviewed
O95140 BXGT024482 Mitofusin-2 9927 reviewed Enzyme
P21926 BXGT024578 CD9 antigen 928 reviewed
P25090 BXGT025102 N-formyl peptide receptor 2 2358 reviewed G-protein coupled receptor
Q96MS0 BXGT025241 Roundabout homolog 3 64221 reviewed Receptor
P19474 BXGT025520 E3 ubiquitin-protein ligase TRIM21 6737 reviewed
Q969H8 BXGT025606 Myeloid-derived growth factor 56005 reviewed
Q7LBE3 BXGT026071 Solute carrier family 26 member 9 115019 reviewed Transporter
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease