Showing entry for Cleft palate, isolated


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD014207
Disease NameCleft palate, isolated
Disease CUI IdC1837218
MeSH Codes C16   C05   C07  
Disease Class NameCongenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
Semantic TypeCongenital Abnormality
Human Phenotype Ontology Id   
Human Phenotype Ontology Term
Disease Ontology Id DOID:225   DOID:0080015  
Disease Ontology Class Namesyndrome; physical disorder
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
O14770 BXGT004095 Homeobox protein Meis2 4212 reviewed Enzyme
O14936 BXGT004114 Peripheral plasma membrane protein CASK 8573 reviewed Kinase
O15111 BXGT004126 Inhibitor of nuclear factor kappa-B kinase subunit alpha 1147 reviewed Kinase
O15119 BXGT004128 T-box transcription factor TBX3 6926 reviewed Transcription factor
O15550 BXGT004179 Lysine-specific demethylase 6A 7403 reviewed Epigenetic regulator
O43255 BXGT004579 E3 ubiquitin-protein ligase SIAH2 6478 reviewed
O43318 BXGT004586 Mitogen-activated protein kinase kinase kinase 7 6885 reviewed Kinase
O43597 BXGT004602 Protein sprouty homolog 2 10253 reviewed Signaling
O60271 BXGT004866 C-Jun-amino-terminal kinase-interacting protein 4 9043 reviewed Enzyme modulator
P00441 BXGT005540 Superoxide dismutase [Cu-Zn] 6647 reviewed Enzyme
P00488 BXGT005552 Coagulation factor XIII A chain 2162 reviewed Enzyme
P00519 BXGT005570 Tyrosine-protein kinase ABL1 25 reviewed Kinase
P00742 BXGT005636 Coagulation factor X 2159 reviewed Enzyme
P01106 BXGT005730 Myc proto-oncogene protein 4609 reviewed Transcription factor
P01133 BXGT005736 Pro-epidermal growth factor 1950 reviewed
P01137 BXGT005737 Transforming growth factor beta-1 proprotein 7040 reviewed Signaling
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01583 BXGT005771 Interleukin-1 alpha 3552 reviewed
P01584 BXGT005772 Interleukin-1 beta 3553 reviewed
P02458 BXGT005879 Collagen alpha-1(II) chain 1280 reviewed
P02741 BXGT005936 C-reactive protein 1401 reviewed
P02753 BXGT005945 Retinol-binding protein 4 5950 reviewed Transporter
P02766 BXGT005953 Transthyretin 7276 reviewed Transporter
P03372 BXGT006059 Estrogen receptor 2099 reviewed Nuclear receptor
P04040 BXGT006132 Catalase 847 reviewed Enzyme
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P04792 BXGT006264 Heat shock protein beta-1 3315 reviewed
P04818 BXGT006269 Thymidylate synthase 7298 reviewed Enzyme
P05177 BXGT006336 Cytochrome P450 1A2 1544 reviewed Enzyme
P05187 BXGT006339 Alkaline phosphatase, placental type 250 reviewed Enzyme
P05231 BXGT006345 Interleukin-6 3569 reviewed
P06401 BXGT006436 Progesterone receptor 5241 reviewed Nuclear receptor
P07099 BXGT006546 Epoxide hydrolase 1 2052 reviewed
P07711 BXGT006661 Cathepsin L1 1514 reviewed Enzyme
P08151 BXGT006731 Zinc finger protein GLI1 2735 reviewed
P08253 BXGT006757 72 kDa type IV collagenase 4313 reviewed Enzyme
P08254 BXGT006758 Stromelysin-1 4314 reviewed Enzyme
P09038 BXGT006851 Fibroblast growth factor 2 2247 reviewed Signaling
P09211 BXGT006869 Glutathione S-transferase P 2950 reviewed
P09488 BXGT006899 Glutathione S-transferase Mu 1 2944 reviewed
P09619 BXGT006911 Platelet-derived growth factor receptor beta 5159 reviewed Kinase
P0CG47 BXGT007467 Polyubiquitin-B 7314 reviewed Nucleic acid binding
P0DN79 BXGT007511 Cystathionine beta-synthase-like protein 875 reviewed
P10070 BXGT007534 Zinc finger protein GLI2 2736 reviewed
P10145 BXGT007542 Interleukin-8 3576 reviewed Signaling
P10276 BXGT007553 Retinoic acid receptor alpha 5914 reviewed Nuclear receptor
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P10600 BXGT007584 Transforming growth factor beta-3 proprotein 7043 reviewed Signaling
P11021 BXGT007644 Endoplasmic reticulum chaperone BiP 3309 reviewed
P11362 BXGT007693 Fibroblast growth factor receptor 1 2260 reviewed Kinase
P12004 BXGT007766 Proliferating cell nuclear antigen 5111 reviewed Nucleic acid binding
P12643 BXGT007830 Bone morphogenetic protein 2 650 reviewed Signaling
P12830 BXGT007852 Cadherin-1 999 reviewed
P13631 BXGT007929 Retinoic acid receptor gamma 5916 reviewed Nuclear receptor
P14921 BXGT008068 Protein C-ets-1 2113 reviewed Transcription factor
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P16234 BXGT008209 Platelet-derived growth factor receptor alpha 5156 reviewed Kinase
P16410 BXGT008224 Cytotoxic T-lymphocyte protein 4 1493 reviewed
P18440 BXGT008404 Arylamine N-acetyltransferase 1 9 reviewed Enzyme
P20702 BXGT008592 Integrin alpha-X 3687 reviewed
P21589 BXGT008669 5'-nucleotidase 4907 reviewed Enzyme
P21802 BXGT008691 Fibroblast growth factor receptor 2 2263 reviewed Kinase
P22607 BXGT008784 Fibroblast growth factor receptor 3 2261 reviewed Kinase
P22897 BXGT008816 Macrophage mannose receptor 1 4360 reviewed
P27482 BXGT009185 Calmodulin-like protein 3 810 reviewed Calcium-binding protein
P28472 BXGT009260 Gamma-aminobutyric acid receptor subunit beta-3 2562 reviewed Ion channel
P29323 BXGT009334 Ephrin type-B receptor 2 2048 reviewed Kinase
P29474 BXGT009352 Nitric oxide synthase, endothelial 4846 reviewed
P29965 BXGT009388 CD40 ligand 959 reviewed Signaling
P30711 BXGT009460 Glutathione S-transferase theta-1 2952 reviewed
P35222 BXGT009799 Catenin beta-1 1499 reviewed
P35520 BXGT009842 Cystathionine beta-synthase 875 reviewed
P35869 BXGT009877 Aryl hydrocarbon receptor 196 reviewed Transcription factor
P37173 BXGT009970 TGF-beta receptor type-2 7048 reviewed Kinase
P39019 BXGT010082 40S ribosomal protein S19 6223 reviewed Nucleic acid binding
P40763 BXGT010202 Signal transducer and activator of transcription 3 6774 reviewed Nucleic acid binding
P41440 BXGT010261 Folate transporter 1 6573 reviewed Transporter
P42345 BXGT010304 Serine/threonine-protein kinase mTOR 2475 reviewed Kinase
P42574 BXGT010317 Caspase-3 836 reviewed Enzyme
P42898 BXGT010344 Methylenetetrahydrofolate reductase 4524 reviewed
P46527 BXGT010525 Cyclin-dependent kinase inhibitor 1B 1027 reviewed
P46531 BXGT010526 Neurogenic locus notch homolog protein 1 4851 reviewed
P49116 BXGT010678 Nuclear receptor subfamily 2 group C member 2 7182 reviewed Nuclear receptor
P49914 BXGT010762 5-formyltetrahydrofolate cyclo-ligase 10588 reviewed Enzyme
P54753 BXGT011073 Ephrin type-B receptor 3 2049 reviewed Kinase
P54764 BXGT011078 Ephrin type-A receptor 4 2043 reviewed Kinase
P56524 BXGT011176 Histone deacetylase 4 9759 reviewed Epigenetic regulator
P60568 BXGT011315 Interleukin-2 3558 reviewed
P61073 BXGT011352 C-X-C chemokine receptor type 4 7852 reviewed G-protein coupled receptor
P63165 BXGT011506 Small ubiquitin-related modifier 1 7341 reviewed
P81605 BXGT011954 Dermcidin 117159 reviewed
P84022 BXGT012027 Mothers against decapentaplegic homolog 3 4088 reviewed Transcription factor
Q01196 BXGT012575 Runt-related transcription factor 1 861 reviewed Transcription factor
Q01974 BXGT012628 Tyrosine-protein kinase transmembrane receptor ROR2 4920 reviewed Kinase
Q07973 BXGT012952 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial 1591 reviewed Enzyme
Q12959 BXGT013283 Disks large homolog 1 1739 reviewed Receptor
Q13464 BXGT013357 Rho-associated protein kinase 1 6093 reviewed Kinase
Q13951 BXGT013407 Core-binding factor subunit beta 865 reviewed
Q14116 BXGT013442 Interleukin-18 3606 reviewed
Q14392 BXGT013465 Transforming growth factor beta activator LRRC32 2615 reviewed Receptor
Q14683 BXGT013500 Structural maintenance of chromosomes protein 1A 8243 reviewed
Q15029 BXGT013524 116 kDa U5 small nuclear ribonucleoprotein component 9343 reviewed Enzyme
Q15109 BXGT013537 Advanced glycosylation end product-specific receptor 177 reviewed Receptor
Q15223 BXGT013551 Nectin-1 5818 reviewed
Q15796 BXGT013599 Mothers against decapentaplegic homolog 2 4087 reviewed Transcription factor
Q2M1P5 BXGT014129 Kinesin-like protein KIF7 374654 reviewed
Q676U5 BXGT016177 Autophagy-related protein 16-1 55054 reviewed
Q7L266 BXGT016993 Isoaspartyl peptidase/L-asparaginase 80150 reviewed Enzyme
Q8IVA8 BXGT018342 Glutamate decarboxylase 1 (Brain, 67kDa) 2571 unreviewed
Q8IWS0 BXGT018356 PHD finger protein 6 84295 reviewed Nucleic acid binding
Q8NFD5 BXGT018560 AT-rich interactive domain-containing protein 1B 57492 reviewed
Q8WVQ1 BXGT018996 Soluble calcium-activated nucleotidase 1 124583 reviewed
Q92769 BXGT019370 Histone deacetylase 2 3066 reviewed Epigenetic regulator
Q93088 BXGT019458 Betaine--homocysteine S-methyltransferase 1 635 reviewed
Q96PU5 BXGT019711 E3 ubiquitin-protein ligase NEDD4-like 23327 reviewed Enzyme
Q99259 BXGT019915 Glutamate decarboxylase 1 2571 reviewed Enzyme
Q99707 BXGT019952 Methionine synthase 4548 reviewed
Q99828 BXGT019967 Calcium and integrin-binding protein 1 10519 reviewed
Q99836 BXGT019970 Myeloid differentiation primary response protein MyD88 4615 reviewed Enzyme modulator
Q99873 BXGT019972 Protein arginine N-methyltransferase 1 3276 reviewed Epigenetic regulator
Q9BZE4 BXGT020197 Nucleolar GTP-binding protein 1 23560 reviewed
Q9H0A0 BXGT020434 RNA cytidine acetyltransferase 55226 reviewed
Q9H2M3 BXGT020456 S-methylmethionine--homocysteine S-methyltransferase BHMT2 23743 reviewed
Q9NRW4 BXGT021196 Dual specificity protein phosphatase 22 56940 reviewed
Q9NTI5 BXGT021212 Sister chromatid cohesion protein PDS5 homolog B 23047 reviewed Nucleic acid binding
Q9UJU2 BXGT021730 Lymphoid enhancer-binding factor 1 51176 reviewed
Q9ULV1 BXGT021764 Frizzled-4 8322 reviewed G-protein coupled receptor
Q9UPP1 BXGT021800 Histone lysine demethylase PHF8 23133 reviewed
Q9UPZ9 BXGT021804 Serine/threonine-protein kinase ICK 22858 reviewed Kinase
Q9Y219 BXGT022206 Protein jagged-2 3714 reviewed
Q9Y2Q3 BXGT022242 Glutathione S-transferase kappa 1 373156 reviewed
Q7Z4S6 BXGT023001 Kinesin-like protein KIF21A 55605 reviewed Cellular structure
Q16552 BXGT023419 Interleukin-17A 3605 reviewed
Q99958 BXGT023732 Forkhead box protein C2 2303 reviewed Transcription factor
Q9H611 BXGT024211 ATP-dependent DNA helicase PIF1 80119 reviewed
Q8NEZ4 BXGT024850 Histone-lysine N-methyltransferase 2C 58508 reviewed
Q13635 BXGT024910 Protein patched homolog 1 5727 reviewed
P51608 BXGT025073 Methyl-CpG-binding protein 2 4204 reviewed Epigenetic regulator
P58215 BXGT026106 Lysyl oxidase homolog 3 84695 reviewed
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease