Showing entry for Ryanodine receptor 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT003191
Protein NameRyanodine receptor 2
Uniport IdE9Q401
GeneRyr2
Gene Id20191
DomainEF-hand_8; Ins145_P3_rec; Ion_trans; MIR; RIH_assoc; RR_TM4-6; RYDR_ITPR; RyR; SPRY
Pfam PF08709   PF00520   PF02815   PF08454   PF06459   PF01365   PF02026   PF00622  
OrganismMus musculus (Mouse)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0070588 calcium ion transmembrane transport
Biological Process GO:0006816 calcium ion transport
Biological Process GO:0060402 calcium ion transport into cytosol
Biological Process GO:0019722 calcium-mediated signaling
Biological Process GO:0035584 calcium-mediated signaling using intracellular calcium source
Biological Process GO:0060048 cardiac muscle contraction
Biological Process GO:0003300 cardiac muscle hypertrophy
Biological Process GO:0006874 cellular calcium ion homeostasis
Biological Process GO:0071313 cellular response to caffeine
Biological Process GO:0071872 cellular response to epinephrine stimulus
Biological Process GO:0060401 cytosolic calcium ion transport
Biological Process GO:0005513 detection of calcium ion
Biological Process GO:0003143 embryonic heart tube morphogenesis
Biological Process GO:0072599 establishment of protein localization to endoplasmic reticulum
Biological Process GO:0034220 ion transmembrane transport
Biological Process GO:0003220 left ventricular cardiac muscle tissue morphogenesis
Biological Process GO:0071421 manganese ion transmembrane transport
Biological Process GO:0051481 negative regulation of cytosolic calcium ion concentration
Biological Process GO:1901896 positive regulation of ATPase-coupled calcium transmembrane transporter activity
Biological Process GO:0010460 positive regulation of heart rate
Biological Process GO:0051284 positive regulation of sequestering of calcium ion
Biological Process GO:0098735 positive regulation of the force of heart contraction
Biological Process GO:0086029 Purkinje myocyte to ventricular cardiac muscle cell signaling
Biological Process GO:0098910 regulation of atrial cardiac muscle cell action potential
Biological Process GO:0098904 regulation of AV node cell action potential
Biological Process GO:0055117 regulation of cardiac muscle contraction
Biological Process GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling
Biological Process GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
Biological Process GO:0051480 regulation of cytosolic calcium ion concentration
Biological Process GO:0002027 regulation of heart rate
Biological Process GO:0098907 regulation of SA node cell action potential
Biological Process GO:0098911 regulation of ventricular cardiac muscle cell action potential
Biological Process GO:0051209 release of sequestered calcium ion into cytosol
Biological Process GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
Biological Process GO:0031000 response to caffeine
Biological Process GO:0051592 response to calcium ion
Biological Process GO:0001666 response to hypoxia
Biological Process GO:0032026 response to magnesium ion
Biological Process GO:0014850 response to muscle activity
Biological Process GO:0035994 response to muscle stretch
Biological Process GO:0051775 response to redox state
Biological Process GO:0070296 sarcoplasmic reticulum calcium ion transport
Biological Process GO:0097050 type B pancreatic cell apoptotic process
Biological Process GO:0086005 ventricular cardiac muscle cell action potential
molecular function GO:0005262 calcium channel activity
molecular function GO:0048763 calcium-induced calcium release activity
molecular function GO:0005509 calcium ion binding
molecular function GO:0015278 calcium-release channel activity
molecular function GO:0005516 calmodulin binding
molecular function GO:0019899 enzyme binding
molecular function GO:0042802 identical protein binding
molecular function GO:0097159 organic cyclic compound binding
molecular function GO:0034236 protein kinase A catalytic subunit binding
molecular function GO:0034237 protein kinase A regulatory subunit binding
molecular function GO:0019901 protein kinase binding
molecular function GO:0043621 protein self-association
molecular function GO:0005219 ryanodine-sensitive calcium-release channel activity
molecular function GO:0097110 scaffold protein binding
molecular function GO:0043924 suramin binding
cellular component GO:0031672 A band
cellular component GO:0034704 calcium channel complex
cellular component GO:0005737 cytoplasm
cellular component GO:0030659 cytoplasmic vesicle membrane
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
cellular component GO:0016021 integral component of membrane
cellular component GO:0016020 membrane
cellular component GO:0043005 neuron projection
cellular component GO:0005635 nuclear envelope
cellular component GO:0005886 plasma membrane
cellular component GO:0032991 protein-containing complex
cellular component GO:0042383 sarcolemma
cellular component GO:0030017 sarcomere
cellular component GO:0016529 sarcoplasmic reticulum
cellular component GO:0033017 sarcoplasmic reticulum membrane
cellular component GO:0005790 smooth endoplasmic reticulum
cellular component GO:0030018 Z disc
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002591 Potassium 39.1
BXGC0003705 Chloride 35.45
BXGC0004266 2-Propanol 60.1
BXGC0004277 Acetic acid 60.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein