Showing entry for Replicase polyprotein 1a


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT003812
Protein NameReplicase polyprotein 1a
Uniport IdK9N638
Gene1a
Gene Id
DomainCorona_NSP4_C; Macro; NAR; NSP10; nsp7; nsp8; nsp9; Peptidase_C30; SUD-M; Viral_protease
Pfam PF16348   PF01661   PF16251   PF09401   PF08716   PF08717   PF08710   PF05409   PF11633   PF08715  
OrganismMiddle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (Betacoronavirus England 1) (Human coronavirus EMC)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0039595 induction by virus of catabolism of host mRNA
Biological Process GO:0039520 induction by virus of host autophagy
Biological Process GO:0039648 modulation by virus of host protein ubiquitination
Biological Process GO:0039548 suppression by virus of host IRF3 activity
Biological Process GO:0039579 suppression by virus of host ISG15 activity
Biological Process GO:0039502 suppression by virus of host type I interferon-mediated signaling pathway
Biological Process GO:0019079 viral genome replication
Biological Process GO:0019082 viral protein processing
molecular function GO:0004197 cysteine-type endopeptidase activity
molecular function GO:0003727 single-stranded RNA binding
molecular function GO:0036459 thiol-dependent ubiquitinyl hydrolase activity
molecular function GO:0016740 transferase activity
molecular function GO:0008270 zinc ion binding
cellular component GO:0033644 host cell membrane
cellular component GO:0044220 host cell perinuclear region of cytoplasm
cellular component GO:0016021 integral component of membrane
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002586 Calcium 40.08
BXGC0002588 Magnesium 24.31
BXGC0030612 tetraethylene glycol 194.12
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein