Showing entry for Replicase polyprotein 1ab


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT003813
Protein NameReplicase polyprotein 1ab
Uniport IdK9N7C7
Generep
Gene Id
DomainA_12; A_30; Corona_NSP4_C; Corona_RPol_N; Macro; NAR; NSP10; NSP11; NSP16; nsp7; nsp8; nsp9; Peptidase_C30; RdRP_1; SUD-M; Viral_protease
Pfam PF13087   PF16348   PF06478   PF01661   PF16251   PF09401   PF06471   PF06460   PF08716   PF08717   PF08710   PF05409   PF00680   PF11633   PF08715  
OrganismMiddle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (Betacoronavirus England 1) (Human coronavirus EMC)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0039595 induction by virus of catabolism of host mRNA
Biological Process GO:0039520 induction by virus of host autophagy
Biological Process GO:0032259 methylation
Biological Process GO:0039648 modulation by virus of host protein ubiquitination
Biological Process GO:0071108 protein K48-linked deubiquitination
Biological Process GO:0070536 protein K63-linked deubiquitination
Biological Process GO:0039503 suppression by virus of host innate immune response
Biological Process GO:0039579 suppression by virus of host ISG15 activity
Biological Process GO:0039644 suppression by virus of host NF-kappaB transcription factor activity
Biological Process GO:0039653 suppression by virus of host transcription
Biological Process GO:0039604 suppression by virus of host translation
Biological Process GO:0039502 suppression by virus of host type I interferon-mediated signaling pathway
Biological Process GO:0006351 transcription, DNA-templated
Biological Process GO:0019082 viral protein processing
Biological Process GO:0039694 viral RNA genome replication
molecular function GO:0005524 ATP binding
molecular function GO:0004197 cysteine-type endopeptidase activity
molecular function GO:0003678 DNA helicase activity
molecular function GO:0004519 endonuclease activity
molecular function GO:0004527 exonuclease activity
molecular function GO:0008168 methyltransferase activity
molecular function GO:0003968 RNA-directed 5'-3' RNA polymerase activity
molecular function GO:0003724 RNA helicase activity
molecular function GO:0003727 single-stranded RNA binding
molecular function GO:0036459 thiol-dependent ubiquitinyl hydrolase activity
molecular function GO:0008270 zinc ion binding
cellular component GO:0044172 host cell endoplasmic reticulum-Golgi intermediate compartment
cellular component GO:0033644 host cell membrane
cellular component GO:0044220 host cell perinuclear region of cytoplasm
cellular component GO:0016021 integral component of membrane
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0004266 2-Propanol 60.1
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein