Showing entry for Beta-mannosidase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT003925
Protein NameBeta-mannosidase
Uniport IdO00462
GeneMANBA
Gene Id4126
DomainGlyco_hydro_2_C; Ig_mannosidase; Mannosidase_ig
Pfam PF02836   PF17753   PF17786  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.7 Glycan biosynthesis and metabolism hsa00511 Other glycan degradation
4. Cellular Processes 4.1 Transport and catabolism hsa04142 Lysosome
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006464 cellular protein modification process
Biological Process GO:0006516 glycoprotein catabolic process
Biological Process GO:0043312 neutrophil degranulation
Biological Process GO:0009313 oligosaccharide catabolic process
molecular function GO:0004567 beta-mannosidase activity
molecular function GO:0005537 mannose binding
cellular component GO:0035577 azurophil granule membrane
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0043202 lysosomal lumen
cellular component GO:0005764 lysosome
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-6798695 Neutrophil degranulation
R-HSA-71387 Metabolism of carbohydrates
R-HSA-8853383 Lysosomal oligosaccharide catabolism
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001807 BXGD000077 Aggressive behavior Behavior and Behavior Mechanisms
C0002985 BXGD000164 Angiokeratoma Neoplasms
C0002986 BXGD000165 Fabry Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Cardiovascular Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0008312 BXGD000527 Primary biliary cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0008313 BXGD000528 Cholangitis, Sclerosing Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009806 BXGD000633 Constipation Pathological Conditions, Signs and Symptoms
C0017654 BXGD001136 Glomerular Filtration Rate
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0036202 BXGD002581 Sarcoidosis Hemic and Lymphatic Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037822 BXGD002706 Speech Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0085078 BXGD003118 Lysosomal Storage Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0200635 BXGD004041 Lymphocyte Count measurement
C0201976 BXGD004063 Creatinine measurement, serum (procedure)
C0239998 BXGD005012 Recurrent infections Pathological Conditions, Signs and Symptoms; Infections; Musculoskeletal Diseases
C0270612 BXGD006081 Leukoencephalopathy Nervous System Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0424503 BXGD008532 Dysmorphic facies
C0494475 BXGD009030 Tonic - clonic seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1527304 BXGD013266 Allergic Reaction Immune System Diseases
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1855391 BXGD015494 Tortuosity of conjunctival vessels
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2931893 BXGD018092 Lysosomal beta-mannosidase deficiency
C2985280 BXGD018223 Blood Protein Measurement
C3279407 BXGD018756 Hypoplasia of the abdominal wall musculature
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3806482 BXGD019514 Recurrent respiratory infections Infections; Respiratory Tract Diseases
C4021768 BXGD020766 Abnormality of metabolism/homeostasis
C4023062 BXGD021090 Increased urinary disaccharide excretion
C4048196 BXGD021892 beta-Mannosidosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0030236 Deoxymannojirimycin 163.08
BXGC0032319 L-Ido-1-Deoxynojirimycin 163.08
BXGC0041132 Duvoglustat 163.08
BXGC0049562 L-1-Deoxynojirimycin 163.08
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein