Showing entry for Ficolin-1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT003940
Protein NameFicolin-1
Uniport IdO00602
GeneFCN1
Gene Id2219
DomainCollagen; Fibrinogen_C
Pfam PF01391   PF00147  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0002752 cell surface pattern recognition receptor signaling pathway
Biological Process GO:0006956 complement activation
Biological Process GO:0001867 complement activation, lectin pathway
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0046597 negative regulation of viral entry into host cell
Biological Process GO:0043312 neutrophil degranulation
Biological Process GO:0032757 positive regulation of interleukin-8 production
Biological Process GO:0034394 protein localization to cell surface
Biological Process GO:0043654 recognition of apoptotic cell
molecular function GO:0003823 antigen binding
molecular function GO:0030246 carbohydrate binding
molecular function GO:0097367 carbohydrate derivative binding
molecular function GO:0001664 G protein-coupled receptor binding
molecular function GO:0046872 metal ion binding
molecular function GO:0038187 pattern recognition receptor activity
molecular function GO:0033691 sialic acid binding
molecular function GO:0005102 signaling receptor binding
cellular component GO:0062023 collagen-containing extracellular matrix
cellular component GO:0005581 collagen trimer
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:0031232 extrinsic component of external side of plasma membrane
cellular component GO:1904813 ficolin-1-rich granule lumen
cellular component GO:0034774 secretory granule lumen
Reactome
Pathway Id Pathway Name
R-HSA-166658 Complement cascade
R-HSA-166662 Lectin pathway of complement activation
R-HSA-166663 Initial triggering of complement
R-HSA-166786 Creation of C4 and C2 activators
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-2855086 Ficolins bind to repetitive carbohydrate structures on the target cell surface
R-HSA-6798695 Neutrophil degranulation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007785 BXGD000485 Cerebral Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0007786 BXGD000486 Brain Ischemia Nervous System Diseases; Cardiovascular Diseases
C0007787 BXGD000487 Transient Ischemic Attack Nervous System Diseases; Cardiovascular Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0015674 BXGD001012 Chronic Fatigue Syndrome Infections; Musculoskeletal Diseases; Nervous System Diseases
C0020473 BXGD001396 Hyperlipidemia Nutritional and Metabolic Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0022661 BXGD001572 Kidney Failure, Chronic Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022681 BXGD001577 Medullary sponge kidney Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023343 BXGD001635 Leprosy Infections
C0023348 BXGD001636 Leprosy, Lepromatous Infections
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0024115 BXGD001732 Lung diseases Respiratory Tract Diseases
C0024143 BXGD001741 Lupus Nephritis Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases; Male Urogenital Diseases; Immune System Diseases
C0026691 BXGD001917 Mucocutaneous Lymph Node Syndrome Skin and Connective Tissue Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0029118 BXGD002111 Opportunistic Infections Infections
C0035436 BXGD002550 Rheumatic Fever Infections; Musculoskeletal Diseases
C0035439 BXGD002551 Rheumatic Heart Disease Infections; Cardiovascular Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0038525 BXGD002768 Subarachnoid Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0042384 BXGD002979 Vasculitis Cardiovascular Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0520459 BXGD009084 Necrotizing Enterocolitis Digestive System Diseases
C0917805 BXGD011414 Transient Cerebral Ischemia Nervous System Diseases; Cardiovascular Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1536220 BXGD013341 ST segment elevation myocardial infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1623038 BXGD013475 Cirrhosis Pathological Conditions, Signs and Symptoms
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2316810 BXGD017030 Chronic kidney disease stage 5 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2347126 BXGD017036 Microscopic Polyarteritis Immune System Diseases; Nervous System Diseases; Cardiovascular Diseases
C3151085 BXGD018392 MASP2 Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases
C4082937 BXGD022095 Necrotizing enterocolitis in fetus OR newborn Digestive System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
BXGC0004266 2-Propanol 60.1
BXGC0039153 N-Acetylneuraminic Acid 309.11
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein