Showing entry for 5-oxoprolinase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004105
Protein Name5-oxoprolinase
Uniport IdO14841
GeneOPLAH
Gene Id26873
DomainHydantoinase_A; Hydantoinase_B; Hydant_A_N
Pfam PF05378   PF01968   PF02538  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.6 Metabolism of other amino acids hsa00480 Glutathione metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006750 glutathione biosynthetic process
Biological Process GO:0006749 glutathione metabolic process
molecular function GO:0017168 5-oxoprolinase (ATP-hydrolyzing) activity
molecular function GO:0005524 ATP binding
molecular function GO:0042802 identical protein binding
cellular component GO:0005829 cytosol
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-156580 Phase II - Conjugation of compounds
R-HSA-156590 Glutathione conjugation
R-HSA-1643685 Disease
R-HSA-174403 Glutathione synthesis and recycling
R-HSA-211859 Biological oxidations
R-HSA-5578998 Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD)
R-HSA-5579029 Metabolic disorders of biological oxidation enzymes
R-HSA-5668914 Diseases of metabolism
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000737 BXGD000005 Abdominal Pain Pathological Conditions, Signs and Symptoms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0014356 BXGD000910 Enterocolitis Digestive System Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0042963 BXGD003018 Vomiting Pathological Conditions, Signs and Symptoms
C0268525 BXGD005971 5-oxoprolinase deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0268534 BXGD005975 Prolinuria
C0398746 BXGD008224 Gluthathione synthetase deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C1833683 BXGD013938 NEPHROLITHIASIS, CALCIUM OXALATE Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C4703642 BXGD023674 Increased level of L-pyroglutamic acid in urine
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0006162 L-Glutamic acid 147.13
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein