Showing entry for Microsomal glutathione S-transferase 3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004108
Protein NameMicrosomal glutathione S-transferase 3
Uniport IdO14880
GeneMGST3
Gene Id4259
DomainMAPEG
Pfam PF01124  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.6 Metabolism of other amino acids hsa00480 Glutathione metabolism
1. Metabolism 1.11 Xenobiotics biodegradation and metabolism hsa00980 Metabolism of xenobiotics by cytochrome P450
1. Metabolism 1.11 Xenobiotics biodegradation and metabolism hsa00982 Drug metabolism - cytochrome P450
1. Metabolism 1.11 Xenobiotics biodegradation and metabolism hsa00983 Drug metabolism - other enzymes
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
6. Human Diseases 6.12 Drug resistance: Antineoplastic hsa01524 Platinum drug resistance
6. Human Diseases 6.1 Cancers: Overview hsa05200 Pathways in cancer
6. Human Diseases 6.1 Cancers: Overview hsa05204 Chemical carcinogenesis
6. Human Diseases 6.2 Cancers: Specific types hsa05225 Hepatocellular carcinoma
6. Human Diseases 6.6 Cardiovascular diseases hsa05418 Fluid shear stress and atherosclerosis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:1901687 glutathione derivative biosynthetic process
Biological Process GO:0019370 leukotriene biosynthetic process
Biological Process GO:0006629 lipid metabolic process
Biological Process GO:0010243 response to organonitrogen compound
Biological Process GO:0006805 xenobiotic metabolic process
molecular function GO:0004602 glutathione peroxidase activity
molecular function GO:0042802 identical protein binding
molecular function GO:0004464 leukotriene-C4 synthase activity
molecular function GO:0016740 transferase activity
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0016021 integral component of membrane
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0016020 membrane
cellular component GO:0005635 nuclear envelope
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-156580 Phase II - Conjugation of compounds
R-HSA-156590 Glutathione conjugation
R-HSA-211859 Biological oxidations
R-HSA-5423646 Aflatoxin activation and detoxification
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0162565 BXGD003957 Acute intermittent porphyria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000926 5-HETE 320.47
BXGC0000989 Glutathione 307.32
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein