Showing entry for Inhibitor of nuclear factor kappa-B kinase subunit beta


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004110
Protein NameInhibitor of nuclear factor kappa-B kinase subunit beta
Uniport IdO14920
GeneIKBKB
Gene Id3551
DomainIKBKB_SDD; IKKbetaNEMObind; Pkinase
Pfam PF18397   PF12179   PF00069  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
6. Human Diseases 6.12 Drug resistance: Antineoplastic hsa01523 Antifolate resistance
3. Environmental Information Processing 3.2 Signal transduction hsa04010 MAPK signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04014 Ras signaling pathway
5. Organismal Systems 5.1 Immune system hsa04062 Chemokine signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04064 NF-kappa B signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04068 FoxO signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04150 mTOR signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04151 PI3K-Akt signaling pathway
4. Cellular Processes 4.2 Cell growth and death hsa04210 Apoptosis
5. Organismal Systems 5.8 Development hsa04380 Osteoclast differentiation
5. Organismal Systems 5.1 Immune system hsa04620 Toll-like receptor signaling pathway
5. Organismal Systems 5.1 Immune system hsa04621 NOD-like receptor signaling pathway
5. Organismal Systems 5.1 Immune system hsa04622 RIG-I-like receptor signaling pathway
5. Organismal Systems 5.1 Immune system hsa04623 Cytosolic DNA-sensing pathway
5. Organismal Systems 5.1 Immune system hsa04625 C-type lectin receptor signaling pathway
5. Organismal Systems 5.1 Immune system hsa04657 IL-17 signaling pathway
5. Organismal Systems 5.1 Immune system hsa04658 Th1 and Th2 cell differentiation
5. Organismal Systems 5.1 Immune system hsa04659 Th17 cell differentiation
5. Organismal Systems 5.1 Immune system hsa04660 T cell receptor signaling pathway
5. Organismal Systems 5.1 Immune system hsa04662 B cell receptor signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04668 TNF signaling pathway
5. Organismal Systems 5.6 Nervous system hsa04722 Neurotrophin signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04910 Insulin signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04920 Adipocytokine signaling pathway
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04930 Type II diabetes mellitus
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04931 Insulin resistance
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04932 Non-alcoholic fatty liver disease (NAFLD)
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05120 Epithelial cell signaling in Helicobacter pylori infection
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05131 Shigellosis
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05135 Yersinia infection
6. Human Diseases 6.10 Infectious diseases: Parasitic hsa05142 Chagas disease (American trypanosomiasis)
6. Human Diseases 6.10 Infectious diseases: Parasitic hsa05145 Toxoplasmosis
6. Human Diseases 6.9 Infectious diseases: Viral hsa05160 Hepatitis C
6. Human Diseases 6.9 Infectious diseases: Viral hsa05161 Hepatitis B
6. Human Diseases 6.9 Infectious diseases: Viral hsa05162 Measles
6. Human Diseases 6.9 Infectious diseases: Viral hsa05163 Human cytomegalovirus infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05164 Influenza A
6. Human Diseases 6.9 Infectious diseases: Viral hsa05165 Human papillomavirus infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05166 Human T-cell leukemia virus 1 infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05167 Kaposi sarcoma-associated herpesvirus infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05168 Herpes simplex virus 1 infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05169 Epstein-Barr virus infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05170 Human immunodeficiency virus 1 infection
6. Human Diseases 6.1 Cancers: Overview hsa05200 Pathways in cancer
6. Human Diseases 6.1 Cancers: Overview hsa05206 MicroRNAs in cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05212 Pancreatic cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05215 Prostate cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05220 Chronic myeloid leukemia
6. Human Diseases 6.2 Cancers: Specific types hsa05221 Acute myeloid leukemia
6. Human Diseases 6.2 Cancers: Specific types hsa05222 Small cell lung cancer
6. Human Diseases 6.1 Cancers: Overview hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
6. Human Diseases 6.6 Cardiovascular diseases hsa05418 Fluid shear stress and atherosclerosis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
Biological Process GO:0071356 cellular response to tumor necrosis factor
Biological Process GO:0030866 cortical actin cytoskeleton organization
Biological Process GO:0038095 Fc-epsilon receptor signaling pathway
Biological Process GO:0007249 I-kappaB kinase/NF-kappaB signaling
Biological Process GO:0006954 inflammatory response
Biological Process GO:0045087 innate immune response
Biological Process GO:0070498 interleukin-1-mediated signaling pathway
Biological Process GO:0002756 MyD88-independent toll-like receptor signaling pathway
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:1903347 negative regulation of bicellular tight junction assembly
Biological Process GO:0035509 negative regulation of myosin-light-chain-phosphatase activity
Biological Process GO:0018105 peptidyl-serine phosphorylation
Biological Process GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
Biological Process GO:0051092 positive regulation of NF-kappaB transcription factor activity
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0072659 protein localization to plasma membrane
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:1903140 regulation of establishment of endothelial barrier
Biological Process GO:0042325 regulation of phosphorylation
Biological Process GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
Biological Process GO:0009615 response to virus
Biological Process GO:0002223 stimulatory C-type lectin receptor signaling pathway
Biological Process GO:0051403 stress-activated MAPK cascade
Biological Process GO:0050852 T cell receptor signaling pathway
Biological Process GO:0035666 TRIF-dependent toll-like receptor signaling pathway
Biological Process GO:0033209 tumor necrosis factor-mediated signaling pathway
Biological Process GO:0016032 viral process
molecular function GO:0005524 ATP binding
molecular function GO:0042802 identical protein binding
molecular function GO:0008384 IkappaB kinase activity
molecular function GO:0046982 protein heterodimerization activity
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0004672 protein kinase activity
molecular function GO:0019901 protein kinase binding
molecular function GO:0004674 protein serine/threonine kinase activity
molecular function GO:0097110 scaffold protein binding
molecular function GO:1990459 transferrin receptor binding
cellular component GO:0035631 CD40 receptor complex
cellular component GO:0005737 cytoplasm
cellular component GO:0009898 cytoplasmic side of plasma membrane
cellular component GO:0005829 cytosol
cellular component GO:0008385 IkappaB kinase complex
cellular component GO:0045121 membrane raft
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR)
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR)
R-HSA-1169091 Activation of NF-kappaB in B cells
R-HSA-1169091 Activation of NF-kappaB in B cells
R-HSA-1236974 ER-Phagosome pathway
R-HSA-1236975 Antigen processing-Cross presentation
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-1280218 Adaptive Immune System
R-HSA-1280218 Adaptive Immune System
R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane
R-HSA-166166 MyD88-independent TLR4 cascade
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-168256 Immune System
R-HSA-168638 NOD1/2 Signaling Pathway
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
R-HSA-168898 Toll-like Receptor Cascades
R-HSA-168927 TICAM1, RIP1-mediated IKK complex recruitment
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta
R-HSA-1810476 RIP-mediated NFkB activation via ZBP1
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA
R-HSA-193639 p75NTR signals via NF-kB
R-HSA-193704 p75 NTR receptor-mediated signalling
R-HSA-202403 TCR signaling
R-HSA-202424 Downstream TCR signaling
R-HSA-209543 p75NTR recruits signalling complexes
R-HSA-209560 NF-kB is activated and signals survival
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-HSA-446652 Interleukin-1 family signaling
R-HSA-448424 Interleukin-17 signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-450294 MAP kinase activation
R-HSA-5260271 Diseases of Immune System
R-HSA-5357905 Regulation of TNFR1 signaling
R-HSA-5357956 TNFR1-induced NFkappaB signaling pathway
R-HSA-5602358 Diseases associated with the TLR signaling cascade
R-HSA-5602636 IKBKB deficiency causes SCID
R-HSA-5603027 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
R-HSA-5603029 IkBA variant leads to EDA-ID
R-HSA-5607764 CLEC7A (Dectin-1) signaling
R-HSA-5621481 C-type lectin receptors (CLRs)
R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation
R-HSA-73887 Death Receptor Signalling
R-HSA-75893 TNF signaling
R-HSA-9020702 Interleukin-1 signaling
R-HSA-933542 TRAF6 mediated NF-kB activation
R-HSA-933543 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
R-HSA-937039 IRAK1 recruits IKK complex
R-HSA-937041 IKK complex recruitment mediated by RIP1
R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-HSA-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
R-HSA-975155 MyD88 dependent cascade initiated on endosome
R-HSA-975871 MyD88 cascade initiated on plasma membrane
R-HSA-983169 Class I MHC mediated antigen processing & presentation
R-HSA-983705 Signaling by the B Cell Receptor (BCR)
R-HSA-983705 Signaling by the B Cell Receptor (BCR)
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0001768 BXGD000075 Agammaglobulinemia Immune System Diseases; Hemic and Lymphatic Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007114 BXGD000431 Malignant neoplasm of skin Neoplasms; Skin and Connective Tissue Diseases
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007758 BXGD000475 Cerebellar Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0007787 BXGD000487 Transient Ischemic Attack Nervous System Diseases; Cardiovascular Diseases
C0008354 BXGD000533 Cholera Infections
C0009241 BXGD000595 Cognition Disorders Mental Disorders
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0010823 BXGD000690 Cytomegalovirus Infections Infections
C0011265 BXGD000708 Presenile dementia Nervous System Diseases; Mental Disorders
C0011603 BXGD000734 Dermatitis Skin and Connective Tissue Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0011884 BXGD000762 Diabetic Retinopathy Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0017658 BXGD001138 Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0017661 BXGD001139 IGA Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Immune System Diseases
C0017665 BXGD001141 Membranous glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Immune System Diseases
C0018129 BXGD001175 Graft Rejection
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0020255 BXGD001369 Hydrocephalus Nervous System Diseases
C0020443 BXGD001385 Hypercholesterolemia Nutritional and Metabolic Diseases
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020507 BXGD001413 Hyperplasia Pathological Conditions, Signs and Symptoms
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020557 BXGD001432 Hypertriglyceridemia Nutritional and Metabolic Diseases
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0021655 BXGD001508 Insulin Resistance Nutritional and Metabolic Diseases
C0022568 BXGD001552 Keratitis Eye Diseases
C0023267 BXGD001626 Fibroid Tumor Neoplasms
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023492 BXGD001671 Leukemia, T-Cell Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023493 BXGD001672 Adult T-Cell Lymphoma/Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024305 BXGD001763 Lymphoma, Non-Hodgkin Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026846 BXGD001939 Muscular Atrophy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026918 BXGD001948 Mycobacterium Infections Infections
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027697 BXGD002022 Nephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0028043 BXGD002066 Nicotine Dependence Chemically-Induced Disorders; Mental Disorders
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0029453 BXGD002154 Osteopenia Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029882 BXGD002177 Otitis Media Otorhinolaryngologic Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0032300 BXGD002346 Lobar Pneumonia Infections; Respiratory Tract Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0034067 BXGD002456 Pulmonary Emphysema Respiratory Tract Diseases
C0035222 BXGD002513 Respiratory Distress Syndrome, Adult Respiratory Tract Diseases
C0035243 BXGD002522 Respiratory Tract Infections Infections; Respiratory Tract Diseases
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0036920 BXGD002645 Sezary Syndrome Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0037199 BXGD002671 Sinusitis Infections; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0037286 BXGD002681 Skin Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C0038362 BXGD002749 Stomatitis Stomatognathic Diseases
C0039103 BXGD002791 Synovitis Musculoskeletal Diseases
C0039483 BXGD002813 Giant Cell Arteritis Skin and Connective Tissue Diseases; Immune System Diseases; Nervous System Diseases; Cardiovascular Diseases
C0041341 BXGD002918 Tuberous Sclerosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C0042133 BXGD002960 Uterine Fibroids Neoplasms
C0042769 BXGD002999 Virus Diseases Infections
C0043144 BXGD003032 Wheezing Pathological Conditions, Signs and Symptoms
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079772 BXGD003099 T-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079773 BXGD003100 Lymphoma, T-Cell, Cutaneous Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085109 BXGD003125 Corneal Neovascularization Pathological Conditions, Signs and Symptoms; Eye Diseases
C0085110 BXGD003126 Severe Combined Immunodeficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0151936 BXGD003505 Disorder of tendon Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0152132 BXGD003547 Hypertensive Retinopathy Eye Diseases; Cardiovascular Diseases
C0153381 BXGD003626 Malignant neoplasm of mouth Neoplasms; Stomatognathic Diseases
C0153690 BXGD003684 Secondary malignant neoplasm of bone Pathological Conditions, Signs and Symptoms; Neoplasms; Musculoskeletal Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0202236 BXGD004086 Triglycerides measurement
C0206694 BXGD004245 Mucoepidermoid Carcinoma Neoplasms
C0220641 BXGD004305 Lip and Oral Cavity Carcinoma Neoplasms; Stomatognathic Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0238790 BXGD004956 bone destruction
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0242706 BXGD005191 Hyperoxia Pathological Conditions, Signs and Symptoms
C0271650 BXGD006227 Impaired glucose tolerance Nutritional and Metabolic Diseases
C0278488 BXGD006515 Carcinoma breast stage IV
C0278498 BXGD006521 Malignant neoplasm of stomach stage IV
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0278996 BXGD006621 Malignant Head and Neck Neoplasm Neoplasms
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0333307 BXGD006946 Superficial ulcer Pathological Conditions, Signs and Symptoms
C0333516 BXGD006957 Tumor necrosis Pathological Conditions, Signs and Symptoms
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0339143 BXGD007226 Thyroid associated opthalmopathies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Immune System Diseases; Endocrine System Diseases
C0342649 BXGD007522 Vascular calcification Nutritional and Metabolic Diseases
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0349632 BXGD007939 Splenic Marginal Zone B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0398650 BXGD008212 Immune thrombocytopenic purpura Pathological Conditions, Signs and Symptoms; Immune System Diseases; Hemic and Lymphatic Diseases
C0398686 BXGD008215 Primary immune deficiency disorder Immune System Diseases
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0401151 BXGD008274 Chronic diarrhea Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0428474 BXGD008631 Serum LDL cholesterol measurement
C0494261 BXGD009023 Combined immunodeficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0497327 BXGD009061 Dementia Nervous System Diseases; Mental Disorders
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598766 BXGD009669 Leukemogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677886 BXGD009734 Epithelial ovarian cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0751688 BXGD010551 Malignant Squamous Cell Neoplasm Neoplasms
C0856169 BXGD011096 Endothelial dysfunction
C0857007 BXGD011131 Hyperbilirubinemia, Neonatal Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0887898 BXGD011401 Experimental Lung Inflammation Infections; Respiratory Tract Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1167791 BXGD011776 Skin toxicity
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1257763 BXGD011803 Overnutrition Nutritional and Metabolic Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1290884 BXGD012198 Inflammatory disorder Pathological Conditions, Signs and Symptoms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332201 BXGD012502 Adult Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1335302 BXGD012775 Pancreatic Ductal Adenocarcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1504431 BXGD013144 Idiopathic pneumonia syndrome Infections; Respiratory Tract Diseases
C1519680 BXGD013244 Tumor Immunity Pathological Conditions, Signs and Symptoms
C1519689 BXGD013245 Tumor Promotion Pathological Conditions, Signs and Symptoms; Neoplasms
C1565885 BXGD013403 Direct Hyperbilirubinemia, Neonatal Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1565886 BXGD013404 Indirect Hyperbilirubinemia, Neonatal Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1568272 BXGD013421 Tendinopathy Musculoskeletal Diseases; Wounds and Injuries
C1568868 BXGD013423 Oral Mucositis Stomatognathic Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1708773 BXGD013611 Lung Melanoma Neoplasms; Respiratory Tract Diseases
C1737250 BXGD013725 Progression of non-small cell lung cancer
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1844384 BXGD014629 Recurrent fungal infections
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2938924 BXGD018167 Oestrogen receptor positive breast cancer
C3714636 BXGD019421 Pneumonitis Infections; Respiratory Tract Diseases
C3839280 BXGD019772 High grade serous carcinoma
C3875321 BXGD019874 Inflammatory dermatosis Skin and Connective Tissue Diseases
C3887461 BXGD019876 Head and Neck Carcinoma Neoplasms
C3887524 BXGD019892 Skin Erosion Skin and Connective Tissue Diseases
C4529962 BXGD023178 Fatty Liver Disease
C4703473 BXGD023650 Atherosclerotic lesion Cardiovascular Diseases
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4747743 BXGD023972 IMMUNODEFICIENCY 15B
C4748694 BXGD024010 IMMUNODEFICIENCY 15A
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000528 Salicylic acid 138.12
BXGC0000537 Acetylsalicylic acid 180.16
BXGC0000655 Harmalol 200.24
BXGC0001544 Harmaline 214.26
BXGC0001545 Harmine 212.25
BXGC0004115 Norharman 168.19
BXGC0004580 Carbanilide 212.25
BXGC0004705 Diphenylamine 169.22
BXGC0007014 Harman 182.22
BXGC0012352 Chelerythrine 348.12
BXGC0014682 Bergenin 328.08
BXGC0015579 3,3'-didemethoxynectandrin B 284.14
BXGC0017933 Sulfuretin 270.05
BXGC0019226 (+)-Conocarpan 266.13
BXGC0020368 Gambogic Acid 628.3
BXGC0021006 2-(4-Hydroxyphenyl)-5-(E)-Propenylbenzofuran 250.1
BXGC0021835 7,8-Dihydroxyflavone 254.06
BXGC0022964 (-)-Larreatricin 284.14
BXGC0023872 Adenine 135.05
BXGC0024554 D-luciferin 280
BXGC0025362 Peperomin E 412.12
BXGC0028696 Cichoric Acid 474.08
BXGC0029976 2-(2,4-Dihydroxyphenyl)-5-(E)-Propenylbenzofuran 266.09
BXGC0033112 Acetylcysteine 163.03
BXGC0034256 Rottlerin 516.18
BXGC0037002 Eurycomalactone 348.16
BXGC0039634 4-[5-(3-Hydroxypropyl)-1-Benzofuran-2-Yl]-3-Methoxyphenol 298.12
BXGC0040254 Rataniaphenol I 280.11
BXGC0043599 2-[5-(3-Hydroxypropyl)-1-Benzofuran-2-Yl]-5-Methoxyphenol 298.12
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0047082 Rataniaphenol Iii 280.11
BXGC0047692 Gefitinib 446.15
BXGC0048569 Rataniaphenol Ii 264.12
BXGC0049832 isosclerone 178.06
BXGC0050099 (2E,5S,6S,8Z,11S)-5,6,15-Trihydroxy-17-Methoxy-11-Methyl-12-Oxabicyclo[12.4.0]Octadeca-1(14),2,8,15,17-Pentaene-7,13-Dione 362.14
BXGC0051306 4-((2S,3R)-3-(Hydroxymethyl)-5-((E)-Prop-1-Enyl)-2,3-Dihydrobenzofuran-2-Yl)Phenol 282.13
BXGC0051873 Sl-0101 516.13
BXGC0051995 Wedelolactone 314.04
BXGC0053184 n.a 464.22
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein