Showing entry for Phosphoribosylformylglycinamidine synthase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004123
Protein NamePhosphoribosylformylglycinamidine synthase
Uniport IdO15067
GenePFAS
Gene Id5198
DomainAIRS_C; FGAR-AT_linker; FGAR-AT_N; GATase_5
Pfam PF02769   PF18072   PF18076  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.4 Nucleotide metabolism hsa00230 Purine metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006189 'de novo' IMP biosynthetic process
Biological Process GO:0097065 anterior head development
Biological Process GO:0006541 glutamine metabolic process
Biological Process GO:0009168 purine ribonucleoside monophosphate biosynthetic process
Biological Process GO:0042493 response to drug
molecular function GO:0005524 ATP binding
molecular function GO:0046872 metal ion binding
molecular function GO:0004642 phosphoribosylformylglycinamidine synthase activity
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-15869 Metabolism of nucleotides
R-HSA-73817 Purine ribonucleoside monophosphate biosynthesis
R-HSA-8956320 Nucleobase biosynthesis
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002792 BXGD000129 anaphylaxis Immune System Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0014772 BXGD000948 Red Blood Cell Count measurement
C0015923 BXGD001023 Fetal Alcohol Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Chemically-Induced Disorders
C0018935 BXGD001252 Hematocrit procedure
C0023487 BXGD001669 Acute Promyelocytic Leukemia Neoplasms
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0206624 BXGD004190 Hepatoblastoma Neoplasms
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0518015 BXGD009068 Hemoglobin measurement
C0596887 BXGD009648 mathematical ability
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2316159 BXGD017024 Oral allergy syndrome Immune System Diseases
C2676033 BXGD017322 Hepatoblastoma Caused By Somatic Mutation Digestive System Diseases; Neoplasms
C2745900 BXGD017568 Promyelocytic leukemia
C4528257 BXGD023159 Corpuscular Hemoglobin Concentration Mean
C4554344 BXGD023564 IgE-mediated food allergy Immune System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0006162 L-Glutamic acid 147.13
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein