Showing entry for 1-acyl-sn-glycerol-3-phosphate acyltransferase beta


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004129
Protein Name1-acyl-sn-glycerol-3-phosphate acyltransferase beta
Uniport IdO15120
GeneAGPAT2
Gene Id10555
DomainAcyltransferase
Pfam PF01553  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00561 Glycerolipid metabolism
1. Metabolism 1.3 Lipid metabolism hsa00564 Glycerophospholipid metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
3. Environmental Information Processing 3.2 Signal transduction hsa04072 Phospholipase D signaling pathway
5. Organismal Systems 5.4 Digestive system hsa04975 Fat digestion and absorption
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0016024 CDP-diacylglycerol biosynthetic process
Biological Process GO:0008544 epidermis development
Biological Process GO:0043312 neutrophil degranulation
Biological Process GO:0006654 phosphatidic acid biosynthetic process
Biological Process GO:0006644 phospholipid metabolic process
Biological Process GO:0001961 positive regulation of cytokine-mediated signaling pathway
Biological Process GO:0001819 positive regulation of cytokine production
Biological Process GO:0042493 response to drug
molecular function GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0016021 integral component of membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0035579 specific granule membrane
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1483166 Synthesis of PA
R-HSA-1483206 Glycerophospholipid biosynthesis
R-HSA-1483257 Phospholipid metabolism
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-556833 Metabolism of lipids
R-HSA-6798695 Neutrophil degranulation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000889 BXGD000018 Acanthosis Nigricans Skin and Connective Tissue Diseases
C0001339 BXGD000041 Acute pancreatitis Digestive System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0005937 BXGD000350 Bone Cysts Neoplasms; Musculoskeletal Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007103 BXGD000426 Malignant neoplasm of endometrium Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0007194 BXGD000452 Hypertrophic Cardiomyopathy Cardiovascular Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013390 BXGD000828 Dysmenorrhea Pathological Conditions, Signs and Symptoms
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0019209 BXGD001305 Hepatomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0019572 BXGD001338 Hirsutism Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0020458 BXGD001393 Hyperhidrosis disorder Skin and Connective Tissue Diseases
C0020459 BXGD001394 Hyperinsulinism Nutritional and Metabolic Diseases
C0020505 BXGD001412 Hyperphagia Pathological Conditions, Signs and Symptoms
C0020557 BXGD001432 Hypertriglyceridemia Nutritional and Metabolic Diseases
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0021655 BXGD001508 Insulin Resistance Nutritional and Metabolic Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0023487 BXGD001669 Acute Promyelocytic Leukemia Neoplasms
C0023787 BXGD001698 Lipodystrophy Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0024003 BXGD001726 Lordosis Musculoskeletal Diseases
C0025362 BXGD001866 Mental Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0028949 BXGD002100 Oligomenorrhea Pathological Conditions, Signs and Symptoms
C0029453 BXGD002154 Osteopenia Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0030252 BXGD002199 Palpitations Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0030305 BXGD002206 Pancreatitis Digestive System Diseases
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0034013 BXGD002450 Precocious Puberty Endocrine System Diseases
C0034194 BXGD002472 Pyloric Stenosis Digestive System Diseases
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0038002 BXGD002723 Splenomegaly Pathological Conditions, Signs and Symptoms
C0038449 BXGD002758 Stricture of artery Cardiovascular Diseases
C0085605 BXGD003200 Liver Failure Digestive System Diseases
C0151639 BXGD003452 Decreased fertility in females Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0152421 BXGD003586 Macrotia
C0156394 BXGD003856 Hypertrophy of clitoris Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0158981 BXGD003914 Neonatal diabetes mellitus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Endocrine System Diseases
C0221032 BXGD004374 Familial generalized lipodystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0221170 BXGD004400 Muscular stiffness Nervous System Diseases
C0232940 BXGD004569 Secondary physiologic amenorrhea Pathological Conditions, Signs and Symptoms
C0235986 BXGD004799 Growth hormone excess Musculoskeletal Diseases; Nervous System Diseases; Endocrine System Diseases
C0239998 BXGD005012 Recurrent infections Pathological Conditions, Signs and Symptoms; Infections; Musculoskeletal Diseases
C0241240 BXGD005089 Tall stature
C0268731 BXGD006029 Renal glomerular disease Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0271561 BXGD006213 Somatotropin deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Endocrine System Diseases
C0271694 BXGD006239 Familial partial lipodystrophy Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0281361 BXGD006774 Adenocarcinoma of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0333068 BXGD006920 Flexion contracture Musculoskeletal Diseases
C0340279 BXGD007314 Ventricular hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0392525 BXGD008052 Nephrolithiasis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0399526 BXGD008251 Class III malocclusion Stomatognathic Diseases
C0404531 BXGD008321 Hypertrophy of labia
C0425957 BXGD008555 Secondary amenorrhea Pathological Conditions, Signs and Symptoms
C0426870 BXGD008592 Large hand
C0428977 BXGD008644 Bradycardia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0432291 BXGD008767 Mandibuloacral dysostosis Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0494360 BXGD009026 Lipodystrophy, not elsewhere classified Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0541764 BXGD009259 Delayed bone age
C0545053 BXGD009323 Advanced bone age
C0576225 BXGD009526 Long foot Musculoskeletal Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0683322 BXGD009782 Mental impairment
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1260926 BXGD011844 Abnormal pigmentation
C1280433 BXGD012125 Lipoatrophy Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306503 BXGD012363 Congenital exomphalos Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1531647 BXGD013301 Cerebral ventriculomegaly Nervous System Diseases
C1560305 BXGD013362 Prolonged QTc interval
C1565489 BXGD013401 Renal Insufficiency Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1623038 BXGD013475 Cirrhosis Pathological Conditions, Signs and Symptoms
C1720862 BXGD013691 Congenital Generalized Lipodystrophy Type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C1720863 BXGD013692 Congenital Generalized Lipodystrophy Type 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C1835884 BXGD014061 Triangular face
C1836156 BXGD014085 Progressive proximal muscle weakness
C1837764 BXGD014268 Loss of subcutaneous adipose tissue in limbs
C1837792 BXGD014272 Insulin-resistant diabetes mellitus at puberty
C1837795 BXGD014273 Prominent umbilicus
C1837799 BXGD014274 Generalized muscular appearance from birth
C1837802 BXGD014275 Decreased serum leptin
C1842060 BXGD014491 Prominent supraorbital ridges
C1848701 BXGD014967 Elevated hepatic transaminase
C1849211 BXGD015023 Generalized hirsutism Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C1850830 BXGD015181 Exercise-induced myalgia Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1857276 BXGD015688 Trichohepatoenteric Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases
C1857657 BXGD015732 Reduced subcutaneous adipose tissue
C1858025 BXGD015760 Spinal rigidity
C1859592 BXGD015912 ATRICHIA WITH PAPULAR LESIONS Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C1866241 BXGD016389 Broad foot Musculoskeletal Diseases
C1963217 BXGD016689 Prolonged QTc Interval, CTCAE
C2265792 BXGD017012 Skeletal muscle hypertrophy
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2973725 BXGD018205 Pulmonary arterial hypertension Respiratory Tract Diseases; Cardiovascular Diseases
C3160712 BXGD018467 Palpitations, CTCAE
C3203102 BXGD018555 Idiopathic pulmonary arterial hypertension Respiratory Tract Diseases
C3278923 BXGD018748 Dilated ventricles (finding)
C3495427 BXGD018984 Fanconi-Bickel Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3714796 BXGD019434 Isolated somatotropin deficiency
C3805574 BXGD019481 Increased fracture rate
C4021749 BXGD020754 Cystic angiomatosis of bone Neoplasms; Musculoskeletal Diseases
C4023051 BXGD021084 Abnormality of skeletal muscle fiber size
C4025887 BXGD021847 Abnormal oral cavity morphology
C4317112 BXGD022726 Generalized Lipodystrophy Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C4476537 BXGD022822 Reduced intrathoracic adipose tissue
C4476602 BXGD022838 Reduced intraabdominal adipose tissue
C4511302 BXGD022999 Genetic lipodystrophy Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C4521256 BXGD023058 Glomerulopathy Assessment
C4551472 BXGD023303 Hypertrophic obstructive cardiomyopathy Cardiovascular Diseases
C4551838 BXGD023417 Talipes transversoplanus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C4721453 BXGD023744 Peripheral Nervous System Diseases Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0020756 4-(1,3-Benzothiazol-2-Yl)-2-Methylaniline 240.07
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein