Showing entry for Arachidonate 15-lipoxygenase B


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004148
Protein NameArachidonate 15-lipoxygenase B
Uniport IdO15296
GeneALOX15B
Gene Id247
DomainLipoxygenase; PLAT
Pfam PF00305   PF01477  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00590 Arachidonic acid metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
5. Organismal Systems 5.6 Nervous system hsa04726 Serotonergic synapse
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006915 apoptotic process
Biological Process GO:0019369 arachidonic acid metabolic process
Biological Process GO:1901696 cannabinoid biosynthetic process
Biological Process GO:0071926 endocannabinoid signaling pathway
Biological Process GO:0051122 hepoxilin biosynthetic process
Biological Process GO:0043651 linoleic acid metabolic process
Biological Process GO:0006629 lipid metabolic process
Biological Process GO:0034440 lipid oxidation
Biological Process GO:2001303 lipoxin A4 biosynthetic process
Biological Process GO:0019372 lipoxygenase pathway
Biological Process GO:0045786 negative regulation of cell cycle
Biological Process GO:0030336 negative regulation of cell migration
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0045926 negative regulation of growth
Biological Process GO:0006644 phospholipid metabolic process
Biological Process GO:0090197 positive regulation of chemokine secretion
Biological Process GO:0045618 positive regulation of keratinocyte differentiation
Biological Process GO:0010744 positive regulation of macrophage derived foam cell differentiation
Biological Process GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway
Biological Process GO:0030850 prostate gland development
Biological Process GO:0030856 regulation of epithelial cell differentiation
molecular function GO:0050473 arachidonate 15-lipoxygenase activity
molecular function GO:0036403 arachidonate 8(S)-lipoxygenase activity
molecular function GO:0005509 calcium ion binding
molecular function GO:0005506 iron ion binding
molecular function GO:0016165 linoleate 13S-lipoxygenase activity
molecular function GO:1990136 linoleate 9S-lipoxygenase activity
molecular function GO:0008289 lipid binding
molecular function GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
cellular component GO:0005912 adherens junction
cellular component GO:0005856 cytoskeleton
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0019898 extrinsic component of membrane
cellular component GO:0005925 focal adhesion
cellular component GO:0016020 membrane
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-2142753 Arachidonic acid metabolism
R-HSA-2142770 Synthesis of 15-eicosatetraenoic acid derivatives
R-HSA-556833 Metabolism of lipids
R-HSA-8978868 Fatty acid metabolism
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007112 BXGD000429 Adenocarcinoma of prostate Neoplasms; Male Urogenital Diseases
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0014859 BXGD000961 Esophageal Neoplasms Digestive System Diseases; Neoplasms
C0020443 BXGD001385 Hypercholesterolemia Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0032927 BXGD002381 Precancerous Conditions Neoplasms
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0152018 BXGD003518 Esophageal carcinoma Digestive System Diseases; Neoplasms
C0175754 BXGD004015 Agenesis of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0206667 BXGD004228 Adrenal Cortical Adenoma Neoplasms; Endocrine System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0278996 BXGD006621 Malignant Head and Neck Neoplasm Neoplasms
C0282160 BXGD006797 Aplasia Cutis Congenita Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0546837 BXGD009343 Malignant neoplasm of esophagus Digestive System Diseases; Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1704272 BXGD013537 Benign Prostatic Hyperplasia Male Urogenital Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2937421 BXGD018162 Prostatic Hyperplasia Male Urogenital Diseases
C3714948 BXGD019440 PACHYONYCHIA CONGENITA 3
C3887461 BXGD019876 Head and Neck Carcinoma Neoplasms
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000194 Sanguinarine 332.33
BXGC0000332 Fisetin 286.24
BXGC0000340 Kaempferol 286.24
BXGC0000392 Eriodictyol 288.26
BXGC0000430 Gossypol 518.55
BXGC0000436 Glycerol 92.09
BXGC0000461 Tricetin 302.24
BXGC0000470 Chalconaringenin 272.25
BXGC0000764 L-Ascorbic acid 176.12
BXGC0001002 1,2-Benzenediol 110.11
BXGC0001417 Isotetrandrine 622.75
BXGC0001545 Harmine 212.25
BXGC0001725 2(3H)-Benzothiazolethione 167.25
BXGC0001746 Theaflavin 3,3'-digallate 868.7
BXGC0001767 (E)-Resveratrol 228.25
BXGC0001940 Daphnetin 178.14
BXGC0001991 Juglone 174.15
BXGC0002094 Rhamnetin 316.26
BXGC0002144 Tetradecanoic acid 228.37
BXGC0002298 Glycerol 2-hexadecanoate 330.5
BXGC0002390 Spermine 202.34
BXGC0002586 Calcium 40.08
BXGC0002906 Caffeic acid ester 284.31
BXGC0003066 Phenols 199.27
BXGC0003249 5-Hexyl-2-methylpyridine 270.37
BXGC0003707 Estrogen 268.36
BXGC0004139 Sperminidine 145.25
BXGC0004335 6-Hydroxydaidzein 270.24
BXGC0004378 3-Hydroxyflavone 238.24
BXGC0004965 Rhein 284.22
BXGC0004969 1,4,5-Naphthalenetriol 176.17
BXGC0005659 Arachidonic acid 304.47
BXGC0005682 3,3',4,4'-Tetrahydroxylignan 302.36
BXGC0005683 Quercetin 302.24
BXGC0005793 Baicalein 270.24
BXGC0005982 Curcumin 368.38
BXGC0005985 Piceatannol 244.25
BXGC0006035 Gambogic acid 628.75
BXGC0006107 alpha-Linolenic acid 278.43
BXGC0006193 Ellagic acid 302.19
BXGC0006212 Hypericin 504.44
BXGC0006306 Myricetin 318.24
BXGC0006635 Luteolin 286.24
BXGC0007014 Harman 182.22
BXGC0007028 beta-Thujaplicin 164.2
BXGC0007035 Cryptotanshinone 296.36
BXGC0007471 3H-1,2-Dithiole-3-thione 134.24
BXGC0008101 Sodium nitrite 69
BXGC0008184 Phloretin 274.27
BXGC0012352 Chelerythrine 348.12
BXGC0012974 Formonetin 284.07
BXGC0013582 Curcumin 368.13
BXGC0014455 Fanchinin 622.3
BXGC0014695 Loratadine 382.14
BXGC0015879 Chlorhexidine 504.2
BXGC0016247 3,5-Dihydroxy-2-Phenylchromen-4-One 254.06
BXGC0016891 Nortriptyline 263.17
BXGC0017277 Aurin 290.09
BXGC0017313 (2R)-1-(Propan-2-Ylamino)-3-(2-Prop-2-Enylphenoxy)Propan-2-Ol 249.17
BXGC0018073 2-Phenylethyl (Z)-3-(3,4-Dihydroxyphenyl)Prop-2-Enoate 284.1
BXGC0018252 Embelin 294.18
BXGC0018772 Pseudoephedrine 165.12
BXGC0018843 Quinalizarin 272.03
BXGC0021835 7,8-Dihydroxyflavone 254.06
BXGC0021893 Norepinephrine 169.07
BXGC0022677 (9Z,11E)-13-Oxooctadeca-9,11-Dienoic Acid 294.22
BXGC0023292 Gingkolic Acid 346.25
BXGC0023547 Methyl 2-Hydroxy-4-Methoxy-6-Methylbenzoate 196.07
BXGC0024915 Dehydroglaucine 353.16
BXGC0024988 Nifedipine 346.12
BXGC0027102 Esculin 340.08
BXGC0028001 Beta-Lapachone 242.09
BXGC0029291 Diphyllin 380.09
BXGC0030815 (S)-Verapamil 454.28
BXGC0032290 Anandamide 347.28
BXGC0032634 Chlorothalonil 263.88
BXGC0033389 Zinc;1-Oxidopyridine-2-Thione 126
BXGC0034968 Dienestrol 266.13
BXGC0036681 7,11B-Dihydro-6H-Indeno[2,1-C]Chromene-3,6A,9,10-Tetrol 286.08
BXGC0037152 (Z)-1-[6-[(3-Acetyl-2,4,6-Trihydroxy-5-Methylphenyl)Methyl]-5,7-Dihydroxy-2,2-Dimethylchromen-8-Yl]-3-Phenylprop-2-En-1-One 516.18
BXGC0037407 Lithocholic Acid 376.3
BXGC0038169 (-)-Lobeline 337.2
BXGC0038329 iodoform 393.72
BXGC0038577 Magnolol 266.13
BXGC0039306 Carnosic Acid 332.2
BXGC0039397 Athraquinones A 240.04
BXGC0040109 3,7-Dihydroxyflavone 254.06
BXGC0040213 CEPHARANTHINE 606.27
BXGC0042091 Dequalinium 456.33
BXGC0042143 Methyl 6,18-Dimethoxy-17-(3,4,5-Trimethoxybenzoyl)Oxy-1,3,11,12,14,15,16,17,18,19,20,21-Dodecahydroyohimban-19-Carboxylate 608.27
BXGC0042222 Propranolol 259.16
BXGC0042437 Dalbergione, 4-Methoxy-4'-Hydroxy- 270.09
BXGC0042510 Fluoxetine 309.13
BXGC0042870 Piceatannol 244.07
BXGC0045254 Sb-202190 331.11
BXGC0045746 Diphenyleneiodonium 278.97
BXGC0045812 Trifluoperazine 407.16
BXGC0046737 Berbamine 608.29
BXGC0047692 Gefitinib 446.15
BXGC0047871 7-Hydroxyflavone 238.06
BXGC0048661 Nicardipine Hydrochloride 479.21
BXGC0049263 4-Methoxydalbergione 254.09
BXGC0050599 tetrandrine 622.3
BXGC0051096 (2S,3S,11Bs)-2-[[(1R)-6,7-Dimethoxy-1,2,3,4-Tetrahydroisoquinolin-1-Yl]Methyl]-3-Ethyl-9,10-Dimethoxy-2,3,4,6,7,11B-Hexahydro-1H-Benzo[A]Quinolizine 480.3
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein