Showing entry for Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004156
Protein NamePhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
Uniport IdO15357
GeneINPPL1
Gene Id3636
DomainExo_endo_phos; SAM_1; SH2
Pfam PF03372   PF00536   PF00017  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.1 Carbohydrate metabolism hsa00562 Inositol phosphate metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
3. Environmental Information Processing 3.2 Signal transduction hsa04070 Phosphatidylinositol signaling system
5. Organismal Systems 5.1 Immune system hsa04662 B cell receptor signaling pathway
5. Organismal Systems 5.1 Immune system hsa04666 Fc gamma R-mediated phagocytosis
5. Organismal Systems 5.2 Endocrine system hsa04910 Insulin signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007015 actin filament organization
Biological Process GO:0007155 cell adhesion
Biological Process GO:0019221 cytokine-mediated signaling pathway
Biological Process GO:0001958 endochondral ossification
Biological Process GO:0006897 endocytosis
Biological Process GO:0006006 glucose metabolic process
Biological Process GO:0002376 immune system process
Biological Process GO:0043647 inositol phosphate metabolic process
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0006661 phosphatidylinositol biosynthetic process
Biological Process GO:0046856 phosphatidylinositol dephosphorylation
Biological Process GO:0009791 post-embryonic development
Biological Process GO:0032868 response to insulin
Biological Process GO:0097178 ruffle assembly
molecular function GO:0003779 actin binding
molecular function GO:0016787 hydrolase activity
molecular function GO:0042169 SH2 domain binding
molecular function GO:0017124 SH3 domain binding
cellular component GO:0005856 cytoskeleton
cellular component GO:0005829 cytosol
cellular component GO:0030175 filopodium
cellular component GO:0005794 Golgi apparatus
cellular component GO:0030027 lamellipodium
cellular component GO:0016607 nuclear speck
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-1430728 Metabolism
R-HSA-1483249 Inositol phosphate metabolism
R-HSA-1483255 PI Metabolism
R-HSA-1483257 Phospholipid metabolism
R-HSA-1660499 Synthesis of PIPs at the plasma membrane
R-HSA-168256 Immune System
R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol
R-HSA-449147 Signaling by Interleukins
R-HSA-451927 Interleukin-2 family signaling
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-HSA-556833 Metabolism of lipids
R-HSA-912526 Interleukin receptor SHC signaling
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0005940 BXGD000352 Bone Diseases Musculoskeletal Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007107 BXGD000428 Malignant neoplasm of larynx Neoplasms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0008925 BXGD000575 Cleft Palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010417 BXGD000670 Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0013604 BXGD000859 Edema Pathological Conditions, Signs and Symptoms
C0016842 BXGD001083 Congenital pectus excavatum Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0018081 BXGD001171 Gonorrhea Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019209 BXGD001305 Hepatomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0020224 BXGD001366 Polyhydramnios Female Urogenital Diseases and Pregnancy Complications
C0020534 BXGD001421 Orbital separation excessive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0021655 BXGD001508 Insulin Resistance Nutritional and Metabolic Diseases
C0021670 BXGD001509 insulinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023440 BXGD001646 Acute Erythroblastic Leukemia Neoplasms; Hemic and Lymphatic Diseases
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0024236 BXGD001752 Lymphedema Hemic and Lymphatic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0025995 BXGD001885 Micromelia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0035229 BXGD002516 Respiratory Insufficiency Respiratory Tract Diseases
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0038002 BXGD002723 Splenomegaly Pathological Conditions, Signs and Symptoms
C0038356 BXGD002747 Stomach Neoplasms Digestive System Diseases; Neoplasms
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0041408 BXGD002923 Turner Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0085580 BXGD003191 Essential Hypertension Cardiovascular Diseases
C0162298 BXGD003933 Joint stiffness Musculoskeletal Diseases
C0221354 BXGD004446 Frontal bossing Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0221355 BXGD004447 Macrocephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0221357 BXGD004449 Brachydactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0221358 BXGD004450 Long narrow head
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0242339 BXGD005150 Dyslipidemias Nutritional and Metabolic Diseases
C0271561 BXGD006213 Somatotropin deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Endocrine System Diseases
C0271650 BXGD006227 Impaired glucose tolerance Nutritional and Metabolic Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280324 BXGD006740 Laryngeal Squamous Cell Carcinoma Neoplasms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0343284 BXGD007613 Chondrodysplasia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0426790 BXGD008577 Narrow thorax
C0426805 BXGD008580 Hooked clavicle
C0426817 BXGD008585 Short ribs
C0426886 BXGD008594 Tapering fingers (finding)
C0426891 BXGD008595 Broad thumbs
C0432194 BXGD008731 Schneckenbecken dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0432219 BXGD008741 Opsismodysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0432252 BXGD008755 Osteoporosis with pseudoglioma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0456132 BXGD008869 Large fontanelle
C0521525 BXGD009139 Short neck
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0541764 BXGD009259 Delayed bone age
C0542476 BXGD009276 Forgetful Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0542514 BXGD009277 Blue sclera Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0545053 BXGD009323 Advanced bone age
C0576226 BXGD009527 Short foot
C0595989 BXGD009632 Carcinoma of larynx Neoplasms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0856169 BXGD011096 Endothelial dysfunction
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1832119 BXGD013799 Fibular hypoplasia
C1835473 BXGD014033 Diaphyseal thickening
C1836542 BXGD014129 Depressed nasal bridge
C1837082 BXGD014194 Metaphyseal cupping
C1837279 BXGD014217 Hypoplastic toenails
C1837402 BXGD014228 Flat occiput
C1837483 BXGD014238 Posterior rib cupping
C1837485 BXGD014239 Flat acetabular roof
C1838186 BXGD014301 Squared iliac bones
C1840077 BXGD014434 Anteverted nostril
C1843108 BXGD014556 Short palm
C1846154 BXGD014788 Anterior rib cupping
C1846434 BXGD014814 Hypoplastic scapulae
C1848673 BXGD014963 Hypoplastic feet
C1849293 BXGD015030 Advanced tarsal ossification
C1849937 BXGD015091 Disproportionate short-limb short stature
C1850293 BXGD015126 Severe platyspondyly
C1854114 BXGD015383 Short nose
C1854912 BXGD015441 Short long bone
C1854928 BXGD015443 Protuberant abdomen
C1858085 BXGD015770 Malar flattening
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1859447 BXGD015892 Hypoplastic ischia
C1861218 BXGD016021 Hypoplastic ilia
C1863353 BXGD016168 Hypoplastic vertebral bodies
C1865014 BXGD016282 Long philtrum
C1865030 BXGD016288 Hypoplastic pubic bone
C1865186 BXGD016296 Bell-shaped thorax
C1866730 BXGD016419 Rhizomelia
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2749582 BXGD017627 Dumbbell-shaped long bone
C3806482 BXGD019514 Recurrent respiratory infections Infections; Respiratory Tract Diseases
C4020966 BXGD020515 Abnormally ossified vertebrae
C4021100 BXGD020554 Increased fibular diameter
C4021611 BXGD020697 Abnormality of epiphysis morphology
C4025814 BXGD021806 Abnormality of the metaphysis
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
BXGC0002722 Nitrate 62
BXGC0003705 Chloride 35.45
BXGC0018772 Pseudoephedrine 165.12
BXGC0030109 Ephedrine 165.12
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein