Showing entry for Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004574
Protein NameSia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase
Uniport IdO43173
GeneST8SIA3
Gene Id51046
DomainGlyco_transf_29
Pfam PF00777  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0001574 ganglioside biosynthetic process
Biological Process GO:0009100 glycoprotein metabolic process
Biological Process GO:0006688 glycosphingolipid biosynthetic process
Biological Process GO:0006491 N-glycan processing
Biological Process GO:0009311 oligosaccharide metabolic process
Biological Process GO:0006486 protein glycosylation
Biological Process GO:1990743 protein sialylation
molecular function GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
molecular function GO:0042802 identical protein binding
molecular function GO:0033691 sialic acid binding
molecular function GO:0008373 sialyltransferase activity
cellular component GO:0000139 Golgi membrane
cellular component GO:0016021 integral component of membrane
Reactome
Pathway Id Pathway Name
R-HSA-392499 Metabolism of proteins
R-HSA-4085001 Sialic acid metabolism
R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
R-HSA-446203 Asparagine N-linked glycosylation
R-HSA-446219 Synthesis of substrates in N-glycan biosythesis
R-HSA-597592 Post-translational protein modification
R-HSA-948021 Transport to the Golgi and subsequent modification
R-HSA-975576 N-glycan antennae elongation in the medial/trans-Golgi
R-HSA-975577 N-Glycan antennae elongation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004782 BXGD000292 Basal Ganglia Diseases Nervous System Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0006198 Citric acid 192.12
BXGC0018397 beta-1,4-mannan 180.06
BXGC0050194 alpha-D-Mannose 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein