protein

Showing entry for Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1

　　　　　　　　　　　　

General Target Information
BXGT Id	BXGT004578
Protein Name	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
Uniport Id	O43252
Gene	PAPSS1
Gene Id	9061
Domain	APS_kinase; ATP-sulfurylase; PUA_2
Pfam	PF01747 PF14306
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name
1. Metabolism	1.4 Nucleotide metabolism	hsa00230	Purine metabolism
1. Metabolism	1.6 Metabolism of other amino acids	hsa00450	Selenocompound metabolism
1. Metabolism	1.2 Energy metabolism	hsa00920	Sulfur metabolism
1. Metabolism	1.0 Global and overview maps	hsa01100	Metabolic pathways

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0050428	3'-phosphoadenosine 5'-phosphosulfate biosynthetic process
Biological Process	GO:0001501	skeletal system development
Biological Process	GO:0000103	sulfate assimilation
molecular function	GO:0004020	adenylylsulfate kinase activity
molecular function	GO:0005524	ATP binding
molecular function	GO:0016779	nucleotidyltransferase activity
molecular function	GO:0042803	protein homodimerization activity
molecular function	GO:0004781	sulfate adenylyltransferase (ATP) activity
cellular component	GO:0005829	cytosol

Reactome

Pathway Id	Pathway Name
R-HSA-1430728	Metabolism
R-HSA-1430728	Metabolism
R-HSA-156580	Phase II - Conjugation of compounds
R-HSA-156584	Cytosolic sulfonation of small molecules
R-HSA-1630316	Glycosaminoglycan metabolism
R-HSA-1643685	Disease
R-HSA-174362	Transport and synthesis of PAPS
R-HSA-211859	Biological oxidations
R-HSA-2408522	Selenoamino acid metabolism
R-HSA-2408550	Metabolism of ingested H2SeO4 and H2SeO3 into H2Se
R-HSA-5663202	Diseases of signal transduction by growth factor receptors and second messengers
R-HSA-6802952	Signaling by BRAF and RAF fusions
R-HSA-6802957	Oncogenic MAPK signaling
R-HSA-71291	Metabolism of amino acids and derivatives
R-HSA-71387	Metabolism of carbohydrates

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0006826	BXGD000408	Malignant Neoplasms	Neoplasms
C0007131	BXGD000441	Non-Small Cell Lung Carcinoma	Neoplasms; Respiratory Tract Diseases
C0019163	BXGD001295	Hepatitis B	Digestive System Diseases; Infections
C0024121	BXGD001735	Lung Neoplasms	Neoplasms; Respiratory Tract Diseases
C0027651	BXGD002009	Neoplasms	Neoplasms
C0152013	BXGD003516	Adenocarcinoma of lung (disorder)	Neoplasms
C0424605	BXGD008535	Developmental delay (disorder)	Mental Disorders
C0557874	BXGD009444	Global developmental delay
C1306459	BXGD012361	Primary malignant neoplasm	Neoplasms
C2239176	BXGD016965	Liver carcinoma	Digestive System Diseases; Neoplasms

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0000436	Glycerol		92.09
BXGC0002588	Magnesium		24.31
BXGC0002591	Potassium		39.1
BXGC0003705	Chloride		35.45

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}