Showing entry for Voltage-dependent T-type calcium channel subunit alpha-1G


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004596
Protein NameVoltage-dependent T-type calcium channel subunit alpha-1G
Uniport IdO43497
GeneCACNA1G
Gene Id8913
DomainIon_trans
Pfam PF00520  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04010 MAPK signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04020 Calcium signaling pathway
5. Organismal Systems 5.10 Environmental adaptation hsa04713 Circadian entrainment
5. Organismal Systems 5.2 Endocrine system hsa04925 Aldosterone synthesis and secretion
5. Organismal Systems 5.2 Endocrine system hsa04927 Cortisol synthesis and secretion
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04930 Type II diabetes mellitus
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04934 Cushing syndrome
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0086016 AV node cell action potential
Biological Process GO:0086027 AV node cell to bundle of His cell signaling
Biological Process GO:0070509 calcium ion import
Biological Process GO:0070588 calcium ion transmembrane transport
Biological Process GO:0086002 cardiac muscle cell action potential involved in contraction
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:0086010 membrane depolarization during action potential
Biological Process GO:0086045 membrane depolarization during AV node cell action potential
Biological Process GO:0086046 membrane depolarization during SA node cell action potential
Biological Process GO:0019228 neuronal action potential
Biological Process GO:0045956 positive regulation of calcium ion-dependent exocytosis
Biological Process GO:0060371 regulation of atrial cardiac muscle cell membrane depolarization
Biological Process GO:0086091 regulation of heart rate by cardiac conduction
Biological Process GO:0034765 regulation of ion transmembrane transport
Biological Process GO:0042391 regulation of membrane potential
Biological Process GO:0010045 response to nickel cation
Biological Process GO:0086015 SA node cell action potential
Biological Process GO:0086018 SA node cell to atrial cardiac muscle cell signaling
molecular function GO:0005261 cation channel activity
molecular function GO:0008332 low voltage-gated calcium channel activity
molecular function GO:0097110 scaffold protein binding
molecular function GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential
molecular function GO:0086059 voltage-gated calcium channel activity involved SA node cell action potential
molecular function GO:0005248 voltage-gated sodium channel activity
cellular component GO:0005737 cytoplasm
cellular component GO:0043005 neuron projection
cellular component GO:0005886 plasma membrane
cellular component GO:0045202 synapse
cellular component GO:0005891 voltage-gated calcium channel complex
cellular component GO:0001518 voltage-gated sodium channel complex
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-375165 NCAM signaling for neurite out-growth
R-HSA-419037 NCAM1 interactions
R-HSA-422475 Axon guidance
R-HSA-9675108 Nervous system development
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001430 BXGD000054 Adenoma Neoplasms
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007758 BXGD000475 Cerebellar Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011168 BXGD000700 Deglutition Disorders Digestive System Diseases; Otorhinolaryngologic Diseases
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0012569 BXGD000777 Diplopia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0013362 BXGD000817 Dysarthria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013421 BXGD000837 Dystonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014548 BXGD000928 Epilepsy, Generalized Nervous System Diseases
C0014553 BXGD000931 Absence Epilepsy Nervous System Diseases
C0017178 BXGD001102 Gastrointestinal Diseases Digestive System Diseases
C0018790 BXGD001221 Cardiac Arrest Cardiovascular Diseases
C0019572 BXGD001338 Hirsutism Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0020490 BXGD001403 Hyperopia Eye Diseases
C0020534 BXGD001421 Orbital separation excessive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0020796 BXGD001468 Profound Mental Retardation Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0025363 BXGD001867 Mental Retardation, Psychosocial Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0034935 BXGD002497 Babinski Reflex
C0036220 BXGD002587 Kaposi Sarcoma Neoplasms; Infections
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036857 BXGD002638 Severe intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0038379 BXGD002752 Strabismus Eye Diseases; Nervous System Diseases
C0039075 BXGD002788 Syndactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0042024 BXGD002949 Urinary Incontinence Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0042571 BXGD002991 Vertigo Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0085606 BXGD003201 Urgency of micturition Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0087012 BXGD003318 Ataxia, Spinocerebellar Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0149721 BXGD003349 Left Ventricular Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0231686 BXGD004508 Gait, Unsteady Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0231687 BXGD004509 Spastic gait Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234162 BXGD004627 Cerebellar Dysmetria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234379 BXGD004662 Resting Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0239882 BXGD005004 Head tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0242350 BXGD005154 Erectile dysfunction Male Urogenital Diseases; Mental Disorders
C0262985 BXGD005277 Psoriasiform eczema Skin and Connective Tissue Diseases
C0265610 BXGD005555 Clinodactyly of fingers Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0266470 BXGD005678 Cerebellar Hypoplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0270736 BXGD006096 Essential Tremor Nervous System Diseases
C0270850 BXGD006117 Idiopathic generalized epilepsy Nervous System Diseases
C0271270 BXGD006178 Oculovestibuloauditory syndrome Eye Diseases; Nervous System Diseases; Cardiovascular Diseases
C0271385 BXGD006193 Horizontal Nystagmus Eye Diseases; Nervous System Diseases
C0333983 BXGD006975 Hyperplastic Polyp Pathological Conditions, Signs and Symptoms
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0399526 BXGD008251 Class III malocclusion Stomatognathic Diseases
C0423082 BXGD008468 Hypometric saccades
C0423109 BXGD008470 Upward slant of palpebral fissure
C0423224 BXGD008475 Sunken eyes Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0424503 BXGD008532 Dysmorphic facies
C0524528 BXGD009229 Pervasive Development Disorder Mental Disorders
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0557874 BXGD009444 Global developmental delay
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0683322 BXGD009782 Mental impairment
C0740279 BXGD009973 Cerebellar atrophy
C0742028 BXGD010051 Cerebellar vermis atrophy
C0751122 BXGD010325 Infantile Severe Myoclonic Epilepsy Nervous System Diseases
C0751265 BXGD010370 Learning Disabilities Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0751837 BXGD010604 Gait Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0752120 BXGD010668 Spinocerebellar Ataxia Type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0752121 BXGD010669 Spinocerebellar Ataxia Type 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0752122 BXGD010670 Spinocerebellar Ataxia Type 4 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0752123 BXGD010671 Spinocerebellar Ataxia Type 5 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0752124 BXGD010672 Spinocerebellar Ataxia Type 6 (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0752125 BXGD010673 Spinocerebellar Ataxia Type 7 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0917816 BXGD011419 Mental deficiency Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0936223 BXGD011477 Metastatic Prostate Carcinoma Neoplasms; Male Urogenital Diseases
C1282496 BXGD012147 Metastasis from malignant tumor of prostate
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1836038 BXGD014073 Poor head control Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1836479 BXGD014121 Saccadic smooth pursuit
C1837770 BXGD014270 Sparse hair
C1839333 BXGD014369 EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 2 Nervous System Diseases
C1849146 BXGD015013 Loss of Purkinje cells in the cerebellar vermis
C1849156 BXGD015017 Spastic Ataxia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Musculoskeletal Diseases; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C1853394 BXGD015333 Gaze-evoked horizontal nystagmus Eye Diseases; Nervous System Diseases
C1853743 BXGD015358 Muscular hypotonia of the trunk Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1854114 BXGD015383 Short nose
C1854372 BXGD015395 Impaired vibration sensation at ankles
C1854494 BXGD015409 Slow progression
C1857055 BXGD015672 Anteverted ears
C1867138 BXGD016442 Upper limb postural tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2675021 BXGD017264 Narrow palpebral fissure
C2938912 BXGD018165 Hyperintensity of cerebral white matter on MRI Pathological Conditions, Signs and Symptoms
C3489733 BXGD018945 Oculomotor apraxia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases; Behavior and Behavior Mechanisms; Cardiovascular Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4021790 BXGD020782 Abnormality of the skeletal system
C4022737 BXGD020973 Neurodevelopmental abnormality
C4022761 BXGD020988 Reduced brain N-acetyl aspartate level by MRS
C4024900 BXGD021463 Atrophy/Degeneration affecting the brainstem
C4087347 BXGD022144 Autosomal dominant cerebellar ataxia
C4225205 BXGD022175 SPINOCEREBELLAR ATAXIA 42
C4281785 BXGD022415 Childhood Absence Epilepsy Nervous System Diseases
C4324277 BXGD022754 Myokymia of eyelid Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4551485 BXGD023312 Clinodactyly
C4553743 BXGD023548 Spasticity, CTCAE
C4553976 BXGD023554 Urinary Urgency, CTCAE 5
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4748120 BXGD023984 SPINOCEREBELLAR ATAXIA 42, EARLY-ONSET, SEVERE, WITH NEURODEVELOPMENTAL DEFICITS
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
BXGC0003611 Latex 416.57
BXGC0006372 Ergocalciferol 396.65
BXGC0008667 6-Prenylnaringenin 340.38
BXGC0024988 Nifedipine 346.12
BXGC0027854 Ethosuximide 141.08
BXGC0029662 Sophoraflavanone G 424.19
BXGC0034783 Doxorubicin 543.17
BXGC0040150 Cannabidiol 314.22
BXGC0042479 8-Prenylnaringenin 340.13
BXGC0044017 Verapamil 454.28
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein