Showing entry for Orexin receptor type 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004606
Protein NameOrexin receptor type 2
Uniport IdO43614
GeneHCRTR2
Gene Id3062
Domain7tm_1; Orexin_rec2
Pfam PF00001   PF03827  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:0022410 circadian sleep/wake cycle process
Biological Process GO:0007631 feeding behavior
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0007218 neuropeptide signaling pathway
Biological Process GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
Biological Process GO:0010840 regulation of circadian sleep/wake cycle, wakefulness
Biological Process GO:0051480 regulation of cytosolic calcium ion concentration
molecular function GO:0004930 G protein-coupled receptor activity
molecular function GO:0008188 neuropeptide receptor activity
molecular function GO:0016499 orexin receptor activity
molecular function GO:0017046 peptide hormone binding
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0045202 synapse
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-372790 Signaling by GPCR
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-388396 GPCR downstream signalling
R-HSA-389397 Orexin and neuropeptides FF and QRFP bind to their respective receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-500792 GPCR ligand binding
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001430 BXGD000054 Adenoma Neoplasms
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003123 BXGD000178 Anorexia Pathological Conditions, Signs and Symptoms
C0005845 BXGD000341 Blood urea nitrogen measurement
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0008810 BXGD000572 Circadian Rhythms
C0009088 BXGD000585 Cluster Headache Nervous System Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0027404 BXGD001984 Narcolepsy Nervous System Diseases; Mental Disorders
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0028043 BXGD002066 Nicotine Dependence Chemically-Induced Disorders; Mental Disorders
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030319 BXGD002208 Panic Disorder Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037317 BXGD002689 Sleep disturbances Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0085281 BXGD003152 Addictive Behavior Behavior and Behavior Mechanisms
C0086132 BXGD003264 Depressive Symptoms Behavior and Behavior Mechanisms
C0149931 BXGD003388 Migraine Disorders Nervous System Diseases
C0206687 BXGD004242 Carcinoma, Endometrioid Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0424574 BXGD008534 Duration of sleep
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0700201 BXGD009880 Dyssomnias Nervous System Diseases; Mental Disorders
C0751362 BXGD010411 Narcolepsy-Cataplexy Syndrome Nervous System Diseases; Mental Disorders
C0851578 BXGD010925 Sleep Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0917801 BXGD011412 Sleeplessness Nervous System Diseases; Mental Disorders
C1851841 BXGD015242 ECTRODACTYLY, ECTODERMAL DYSPLASIA, AND CLEFT LIP/PALATE SYNDROME 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Stomatognathic Diseases
C1861305 BXGD016027 TARSAL-CARPAL COALITION SYNDROME Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C2830004 BXGD017804 Somnolence Pathological Conditions, Signs and Symptoms
C4053506 BXGD021965 ROHHAD syndrome Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4543926 BXGD023281 Narcolepsy type 1 Nervous System Diseases; Mental Disorders
C4551761 BXGD023405 Excessive daytime sleepiness
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0030248 2-(4-Hydroxyphenyl)Chromen-4-One 238.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein