Showing entry for Alpha-actinin-4


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004616
Protein NameAlpha-actinin-4
Uniport IdO43707
GeneACTN4
Gene Id81
DomainCH; EFhand_Ca_insen; Spectrin
Pfam PF00307   PF08726   PF00435  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04510 Focal adhesion
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04520 Adherens junction
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04530 Tight junction
5. Organismal Systems 5.1 Immune system hsa04670 Leukocyte transendothelial migration
4. Cellular Processes 4.5 Cell motility hsa04810 Regulation of actin cytoskeleton
6. Human Diseases 6.10 Infectious diseases: Parasitic hsa05146 Amoebiasis
6. Human Diseases 6.1 Cancers: Overview hsa05203 Viral carcinogenesis
6. Human Diseases 6.3 Immune diseases hsa05322 Systemic lupus erythematosus
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0051017 actin filament bundle assembly
Biological Process GO:0070830 bicellular tight junction assembly
Biological Process GO:0051271 negative regulation of cellular component movement
Biological Process GO:1900025 negative regulation of substrate adhesion-dependent cell spreading
Biological Process GO:0035357 peroxisome proliferator activated receptor signaling pathway
Biological Process GO:0002576 platelet degranulation
Biological Process GO:0030335 positive regulation of cell migration
Biological Process GO:0051272 positive regulation of cellular component movement
Biological Process GO:1901224 positive regulation of NIK/NF-kappaB signaling
Biological Process GO:0048549 positive regulation of pinocytosis
Biological Process GO:0032417 positive regulation of sodium:proton antiporter activity
Biological Process GO:1902396 protein localization to bicellular tight junction
Biological Process GO:0015031 protein transport
Biological Process GO:0042981 regulation of apoptotic process
Biological Process GO:1903506 regulation of nucleic acid-templated transcription
Biological Process GO:0001666 response to hypoxia
Biological Process GO:0048384 retinoic acid receptor signaling pathway
Biological Process GO:0033209 tumor necrosis factor-mediated signaling pathway
Biological Process GO:0030050 vesicle transport along actin filament
molecular function GO:0003779 actin binding
molecular function GO:0051015 actin filament binding
molecular function GO:0005509 calcium ion binding
molecular function GO:0031490 chromatin DNA binding
molecular function GO:0005178 integrin binding
molecular function GO:0044325 ion channel binding
molecular function GO:0035257 nuclear hormone receptor binding
molecular function GO:0030374 nuclear receptor transcription coactivator activity
molecular function GO:0001882 nucleoside binding
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0047485 protein N-terminus binding
molecular function GO:0042974 retinoic acid receptor binding
molecular function GO:0003723 RNA binding
molecular function GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
molecular function GO:0003713 transcription coactivator activity
cellular component GO:0005903 brush border
cellular component GO:0005911 cell-cell junction
cellular component GO:0030863 cortical cytoskeleton
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:0005925 focal adhesion
cellular component GO:0043005 neuron projection
cellular component GO:0016604 nuclear body
cellular component GO:0005634 nucleus
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0031093 platelet alpha granule lumen
cellular component GO:0032991 protein-containing complex
cellular component GO:0031143 pseudopodium
cellular component GO:1990904 ribonucleoprotein complex
cellular component GO:0001725 stress fiber
cellular component GO:0030018 Z disc
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-114608 Platelet degranulation
R-HSA-1500931 Cell-Cell communication
R-HSA-373753 Nephrin family interactions
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-76005 Response to elevated platelet cytosolic Ca2+
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0004114 BXGD000255 Astrocytoma Neoplasms
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007103 BXGD000426 Malignant neoplasm of endometrium Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0013604 BXGD000859 Edema Pathological Conditions, Signs and Symptoms
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0017658 BXGD001138 Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0017661 BXGD001139 IGA Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Immune System Diseases
C0017665 BXGD001141 Membranous glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Immune System Diseases
C0017668 BXGD001143 Focal glomerulosclerosis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0018817 BXGD001235 Atrial Septal Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0019193 BXGD001299 Hepatitis, Toxic Digestive System Diseases; Chemically-Induced Disorders
C0020473 BXGD001396 Hyperlipidemia Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020951 BXGD001473 Immune Complex Diseases Immune System Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022661 BXGD001572 Kidney Failure, Chronic Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024143 BXGD001741 Lupus Nephritis Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases; Male Urogenital Diseases; Immune System Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0024667 BXGD001794 Animal Mammary Neoplasms Neoplasms; Animal Diseases
C0024668 BXGD001795 Mammary Neoplasms, Experimental Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027697 BXGD002022 Nephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027708 BXGD002025 Nephroblastoma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027719 BXGD002027 Nephrosclerosis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027721 BXGD002029 Lipoid nephrosis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027726 BXGD002030 Nephrotic Syndrome Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0029925 BXGD002181 Ovarian Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0033687 BXGD002415 Proteinuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0035078 BXGD002505 Kidney Failure Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0036202 BXGD002581 Sarcoidosis Hemic and Lymphatic Diseases
C0078911 BXGD003053 AIDS-Associated Nephropathy Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases; Immune System Diseases
C0085110 BXGD003126 Severe Combined Immunodeficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0085273 BXGD003149 Erythema Infectiosum Infections; Skin and Connective Tissue Diseases
C0086432 BXGD003281 Hyalinosis, Segmental Glomerular Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0149925 BXGD003387 Small cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0151650 BXGD003454 Renal fibrosis Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0153349 BXGD003621 Malignant neoplasm of tongue Neoplasms; Stomatognathic Diseases
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0156259 BXGD003845 Hypertrophy of kidney Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0158687 BXGD003900 Congenital malformation of genital organs Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0178664 BXGD004032 Glomerulosclerosis (disorder) Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Cardiovascular Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0205696 BXGD004107 Anaplastic carcinoma Neoplasms
C0205697 BXGD004108 Carcinoma, Spindle-Cell Neoplasms
C0205698 BXGD004109 Undifferentiated carcinoma Neoplasms
C0205699 BXGD004110 Carcinomatosis Neoplasms
C0206681 BXGD004236 Adenocarcinoma, Clear Cell Neoplasms
C0206682 BXGD004237 Follicular thyroid carcinoma Neoplasms
C0206754 BXGD004289 Neuroendocrine Tumors Neoplasms
C0220650 BXGD004310 Metastatic malignant neoplasm to brain Pathological Conditions, Signs and Symptoms; Neoplasms; Nervous System Diseases
C0220668 BXGD004317 Congenital contractural arachnodactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0233532 BXGD004589 Maladaptive behavior associated with physical illness Behavior and Behavior Mechanisms
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0239981 BXGD005011 Hypoalbuminemia Hemic and Lymphatic Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0264657 BXGD005409 Renal sclerosis with hypertension Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Cardiovascular Diseases
C0268731 BXGD006029 Renal glomerular disease Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0268747 BXGD006034 Diffuse mesangial sclerosis (disorder) Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0278688 BXGD006562 Stage IV Ovarian Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0333497 BXGD006956 Segmental glomerulosclerosis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0341698 BXGD007416 Atrophy of kidney Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0346989 BXGD007841 Secondary malignant neoplasm of peritoneum
C0403397 BXGD008277 Steroid-resistant nephrotic syndrome Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0403548 BXGD008292 Salcedo syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Male Urogenital Diseases
C0451720 BXGD008826 Nephrotic syndrome, focal and segmental glomerular lesions Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0558353 BXGD009451 Tongue Carcinoma Neoplasms; Stomatognathic Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0677932 BXGD009736 Progressive Neoplastic Disease
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0687120 BXGD009837 Nephronophthisis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0795949 BXGD010768 Galloway Mowat syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Musculoskeletal Diseases; Male Urogenital Diseases; Nervous System Diseases
C0848548 BXGD010881 hypertensive nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Cardiovascular Diseases
C0854078 BXGD010996 Diabetic end stage renal disease
C0854985 BXGD011055 Adenocarcinoma of lung, stage I
C0860207 BXGD011220 Drug-Induced Liver Disease Digestive System Diseases; Chemically-Induced Disorders
C0887833 BXGD011398 Carcinoma, Pancreatic Ductal Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0948750 BXGD011551 Salivary gland carcinoma Neoplasms; Stomatognathic Diseases
C1134719 BXGD011688 Invasive Ductal Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1257925 BXGD011814 Mammary Carcinoma, Animal Neoplasms; Animal Diseases
C1262760 BXGD011886 Hepatitis, Drug-Induced Digestive System Diseases; Chemically-Induced Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1305904 BXGD012349 Familial hematuria
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332900 BXGD012552 Cerebellar hemangioblastoma Neoplasms; Nervous System Diseases
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1333015 BXGD012581 Childhood Kidney Wilms Tumor Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1333964 BXGD012660 Liver Dysplastic Nodule
C1336527 BXGD012847 Carcinoma of urinary bladder, superficial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1533172 BXGD013311 Infantile nystagmus syndrome Eye Diseases; Nervous System Diseases
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1611743 BXGD013456 Familial (FPAH)
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1636149 BXGD013482 Macular dystrophy, corneal type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1704321 BXGD013544 Nephrotic Syndrome, Minimal Change Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1708565 BXGD013606 Invasive Cutaneous Melanoma Neoplasms; Skin and Connective Tissue Diseases
C1709661 BXGD013630 Primary Focal Segmental Glomerulosclerosis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1710040 BXGD013637 Secondary Focal Segmental Glomerulosclerosis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1827293 BXGD013768 Carcinoma of urinary bladder, invasive Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1854494 BXGD015409 Slow progression
C1861403 BXGD016045 Variable expressivity
C1862389 BXGD016126 ATRIAL SEPTAL DEFECT 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1865974 BXGD016358 Hypomagnesemia 1, Intestinal Nutritional and Metabolic Diseases
C1868672 BXGD016519 NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1961102 BXGD016673 Precursor Cell Lymphoblastic Leukemia Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2316810 BXGD017030 Chronic kidney disease stage 5 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2749515 BXGD017622 Collapsing glomerulopathy
C2902887 BXGD017855 Nephrotic syndrome with focal and segmental hyalinosis
C2902888 BXGD017856 Nephrotic syndrome with focal and segmental sclerosis
C2902889 BXGD017857 Nephrotic syndrome with focal glomerulonephritis
C2919166 BXGD017868 Autosomal dominant focal segmental glomerulosclerosis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2931852 BXGD018079 Clear-cell metastatic renal cell carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C3266102 BXGD018597 Steroid resistant nephrotic syndrome of childhood Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C3496337 BXGD019020 Idiopathic Nephrotic Syndrome Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C3539781 BXGD019086 Progressive cGVHD
C3658290 BXGD019256 Drug-Induced Acute Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4049702 BXGD021948 Focal Segmental Glomerulosclerosis, Not Otherwise Specified Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C4086152 BXGD022123 Childhood Astrocytoma Neoplasms
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4277682 BXGD022376 Chemical and Drug Induced Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C4279912 BXGD022378 Chemically-Induced Liver Toxicity Digestive System Diseases; Chemically-Induced Disorders
C4511620 BXGD023007 Autosomal dominant tubulointerstitial kidney disease
C4551527 BXGD023338 Focal segmental glomerulosclerosis 1 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein