Showing entry for Origin recognition complex subunit 5


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004634
Protein NameOrigin recognition complex subunit 5
Uniport IdO43913
GeneORC5
Gene Id5001
DomainA_16; ORC5_C
Pfam PF13191   PF14630  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.2 Cell growth and death hsa04110 Cell cycle
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006260 DNA replication
Biological Process GO:0006270 DNA replication initiation
Biological Process GO:0000082 G1/S transition of mitotic cell cycle
Biological Process GO:0006275 regulation of DNA replication
molecular function GO:0005524 ATP binding
molecular function GO:0003688 DNA replication origin binding
molecular function GO:0000166 nucleotide binding
cellular component GO:0000785 chromatin
cellular component GO:0005829 cytosol
cellular component GO:0000784 nuclear chromosome, telomeric region
cellular component GO:0005664 nuclear origin of replication recognition complex
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0000808 origin recognition complex
Reactome
Pathway Id Pathway Name
R-HSA-113507 E2F-enabled inhibition of pre-replication complex formation
R-HSA-113510 E2F mediated regulation of DNA replication
R-HSA-1640170 Cell Cycle
R-HSA-1640170 Cell Cycle
R-HSA-176187 Activation of ATR in response to replication stress
R-HSA-453279 Mitotic G1 phase and G1/S transition
R-HSA-453279 Mitotic G1 phase and G1/S transition
R-HSA-68616 Assembly of the ORC complex at the origin of replication
R-HSA-68689 CDC6 association with the ORC:origin complex
R-HSA-68827 CDT1 association with the CDC6:ORC:origin complex
R-HSA-68867 Assembly of the pre-replicative complex
R-HSA-68949 Orc1 removal from chromatin
R-HSA-68962 Activation of the pre-replicative complex
R-HSA-69002 DNA Replication Pre-Initiation
R-HSA-69052 Switching of origins to a post-replicative state
R-HSA-69206 G1/S Transition
R-HSA-69206 G1/S Transition
R-HSA-69239 Synthesis of DNA
R-HSA-69242 S Phase
R-HSA-69278 Cell Cycle, Mitotic
R-HSA-69278 Cell Cycle, Mitotic
R-HSA-69306 DNA Replication
R-HSA-69481 G2/M Checkpoints
R-HSA-69620 Cell Cycle Checkpoints
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0023465 BXGD001656 Acute monocytic leukemia Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023470 BXGD001659 Myeloid Leukemia Neoplasms
C0023524 BXGD001681 Leukoencephalopathy, Progressive Multifocal Infections; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0042133 BXGD002960 Uterine Fibroids Neoplasms
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
BXGC0002591 Potassium 39.1
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein