Showing entry for TYRO protein tyrosine kinase-binding protein


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004635
Protein NameTYRO protein tyrosine kinase-binding protein
Uniport IdO43914
GeneTYROBP
Gene Id7305
Domain-
Pfam -  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.8 Development hsa04380 Osteoclast differentiation
5. Organismal Systems 5.1 Immune system hsa04650 Natural killer cell mediated cytotoxicity
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0030036 actin cytoskeleton organization
Biological Process GO:0043277 apoptotic cell clearance
Biological Process GO:0097190 apoptotic signaling pathway
Biological Process GO:0006968 cellular defense response
Biological Process GO:0030900 forebrain development
Biological Process GO:0045087 innate immune response
Biological Process GO:0007229 integrin-mediated signaling pathway
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0002282 microglial cell activation involved in immune response
Biological Process GO:0002274 myeloid leukocyte activation
Biological Process GO:0030889 negative regulation of B cell proliferation
Biological Process GO:0032693 negative regulation of interleukin-10 production
Biological Process GO:1900272 negative regulation of long-term synaptic potentiation
Biological Process GO:0032911 negative regulation of transforming growth factor beta1 production
Biological Process GO:0002283 neutrophil activation involved in immune response
Biological Process GO:0043312 neutrophil degranulation
Biological Process GO:0030316 osteoclast differentiation
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0110090 positive regulation of hippocampal neuron apoptotic process
Biological Process GO:0032731 positive regulation of interleukin-1 beta production
Biological Process GO:0032755 positive regulation of interleukin-6 production
Biological Process GO:0034241 positive regulation of macrophage fusion
Biological Process GO:1904151 positive regulation of microglial cell mediated cytotoxicity
Biological Process GO:0032816 positive regulation of natural killer cell activation
Biological Process GO:1901216 positive regulation of neuron death
Biological Process GO:2001206 positive regulation of osteoclast development
Biological Process GO:2000010 positive regulation of protein localization to cell surface
Biological Process GO:1902685 positive regulation of receptor localization to synapse
Biological Process GO:0032930 positive regulation of superoxide anion generation
Biological Process GO:0042535 positive regulation of tumor necrosis factor biosynthetic process
Biological Process GO:0050821 protein stabilization
Biological Process GO:0050776 regulation of immune response
Biological Process GO:0048678 response to axon injury
Biological Process GO:0007165 signal transduction
molecular function GO:0042802 identical protein binding
molecular function GO:0046872 metal ion binding
molecular function GO:0005102 signaling receptor binding
cellular component GO:0009986 cell surface
cellular component GO:0016021 integral component of membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0030667 secretory granule membrane
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-1280218 Adaptive Immune System
R-HSA-1500931 Cell-Cell communication
R-HSA-168249 Innate Immune System
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-168256 Immune System
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-2172127 DAP12 interactions
R-HSA-2172127 DAP12 interactions
R-HSA-2424491 DAP12 signaling
R-HSA-2424491 DAP12 signaling
R-HSA-373755 Semaphorin interactions
R-HSA-391160 Signal regulatory protein family interactions
R-HSA-416700 Other semaphorin interactions
R-HSA-422475 Axon guidance
R-HSA-6798695 Neutrophil degranulation
R-HSA-9675108 Nervous system development
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001807 BXGD000077 Aggressive behavior Behavior and Behavior Mechanisms
C0001815 BXGD000078 Primary Myelofibrosis Hemic and Lymphatic Diseases
C0001816 BXGD000079 Agnosia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002726 BXGD000125 Amyloidosis Nutritional and Metabolic Diseases
C0003635 BXGD000214 Apraxias Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003862 BXGD000230 Arthralgia Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0004936 BXGD000295 Mental disorders Mental Disorders
C0005937 BXGD000350 Bone Cysts Neoplasms; Musculoskeletal Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0008489 BXGD000546 Chorea Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0009319 BXGD000596 Colitis Digestive System Diseases
C0011265 BXGD000708 Presenile dementia Nervous System Diseases; Mental Disorders
C0011303 BXGD000712 Demyelinating Diseases Nervous System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0014121 BXGD000895 Bacterial Endocarditis Infections; Cardiovascular Diseases
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0016506 BXGD001062 Foot Deformities Musculoskeletal Diseases
C0016663 BXGD001071 Pathological fracture Wounds and Injuries
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017639 BXGD001133 Gliosis Pathological Conditions, Signs and Symptoms
C0018564 BXGD001204 Hand deformities Musculoskeletal Diseases
C0018889 BXGD001243 Helminthiasis Infections
C0020255 BXGD001369 Hydrocephalus Nervous System Diseases
C0021053 BXGD001476 Immune System Diseases Immune System Diseases
C0021368 BXGD001502 Inflammation Pathological Conditions, Signs and Symptoms
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0022107 BXGD001530 Irritable Mood Behavior and Behavior Mechanisms
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023492 BXGD001671 Leukemia, T-Cell Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024143 BXGD001741 Lupus Nephritis Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases; Male Urogenital Diseases; Immune System Diseases
C0024266 BXGD001754 Lymphocytic Choriomeningitis Infections; Nervous System Diseases
C0024312 BXGD001766 Lymphopenia Immune System Diseases; Hemic and Lymphatic Diseases
C0025500 BXGD001874 Mesothelioma Neoplasms
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027066 BXGD001966 Myoclonus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0028945 BXGD002099 oligodendroglioma Neoplasms
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0029422 BXGD002142 Osteochondrodysplasias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0029453 BXGD002154 Osteopenia Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029454 BXGD002155 Osteopetrosis Musculoskeletal Diseases
C0029883 BXGD002178 Otitis Media with Effusion Otorhinolaryngologic Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0034935 BXGD002497 Babinski Reflex
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037822 BXGD002706 Speech Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0041956 BXGD002942 Ureteral obstruction Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0042024 BXGD002949 Urinary Incontinence Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0085669 BXGD003233 Acute leukemia Pathological Conditions, Signs and Symptoms; Neoplasms
C0086565 BXGD003295 Liver Dysfunction Digestive System Diseases
C0149939 BXGD003390 Obstructive nephropathy Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0151611 BXGD003447 Electroencephalogram abnormal Nervous System Diseases
C0151825 BXGD003481 Bone pain Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0153014 BXGD003612 Non-arthropod borne lymphocytic choriomeningitis Infections; Nervous System Diseases
C0162871 BXGD003996 Aortic Aneurysm, Abdominal Cardiovascular Diseases
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0233522 BXGD004585 Inappropriate behavior Behavior and Behavior Mechanisms
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0234410 BXGD004665 Physiologic disinhibition
C0235146 BXGD004724 Euphoric mood Behavior and Behavior Mechanisms
C0235946 BXGD004789 Cerebral atrophy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0240735 BXGD005052 Personality Change Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0270612 BXGD006081 Leukoencephalopathy Nervous System Diseases
C0270685 BXGD006084 Cerebral calcification Nutritional and Metabolic Diseases; Nervous System Diseases
C0271270 BXGD006178 Oculovestibuloauditory syndrome Eye Diseases; Nervous System Diseases; Cardiovascular Diseases
C0278488 BXGD006515 Carcinoma breast stage IV
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0282687 BXGD006826 Hemorrhagic Fever, Ebola Infections
C0334583 BXGD007124 Pilocytic Astrocytoma Neoplasms
C0338455 BXGD007177 Dementia of frontal lobe type Nervous System Diseases; Mental Disorders
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0344482 BXGD007678 Hypoplasia of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0410528 BXGD008430 Skeletal dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0410533 BXGD008433 Osteodysplasia
C0422895 BXGD008464 Primitive reflex
C0424296 BXGD008525 Social disinhibition Mental Disorders
C0432214 BXGD008738 Namaqualand hip dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0494463 BXGD009029 Alzheimer Disease, Late Onset Nervous System Diseases; Mental Disorders
C0497327 BXGD009061 Dementia Nervous System Diseases; Mental Disorders
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0542476 BXGD009276 Forgetful Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0575081 BXGD009512 Gait abnormality Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0699889 BXGD009870 Malignant Female Reproductive System Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0699949 BXGD009872 airway disease Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0750901 BXGD010242 Alzheimer Disease, Early Onset Nervous System Diseases; Mental Disorders
C0751396 BXGD010425 Well Differentiated Oligodendroglioma Neoplasms
C0871189 BXGD011312 Psychotic symptom
C0878575 BXGD011372 Peripheral demyelination Nervous System Diseases
C0919747 BXGD011439 Cytokine storm
C0949664 BXGD011583 Tauopathies Nervous System Diseases
C1285498 BXGD012171 Vegetation
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1389280 BXGD012967 Basal ganglia calcification
C1522378 BXGD013254 Leukemia, Large Granular Lymphocytic Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1531647 BXGD013301 Cerebral ventriculomegaly Nervous System Diseases
C1541923 BXGD013355 Infective endocarditis Cardiovascular Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1832338 BXGD013829 Axonal loss
C1836830 BXGD014165 Developmental regression Mental Disorders
C1838319 BXGD014309 Primitive reflexes (palmomental, snout, glabellar) Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1857108 BXGD015677 Limitation of joint mobility
C1857316 BXGD015695 POLYCYSTIC LIPOMEMBRANOUS OSTEODYSPLASIA WITH SCLEROSING LEUKOENCEPHALOPATHY Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Infections; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Nervous System Diseases
C1858116 BXGD015773 Caudate atrophy
C1963077 BXGD016680 Bone Pain, CTCAE 3.0
C1963167 BXGD016686 Memory Impairment, CTCAE 3.0
C2674432 BXGD017246 Reduced bone mineral density
C2700617 BXGD017474 Irritation - emotion Behavior and Behavior Mechanisms
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3278923 BXGD018748 Dilated ventricles (finding)
C3489733 BXGD018945 Oculomotor apraxia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases; Behavior and Behavior Mechanisms; Cardiovascular Diseases
C3665444 BXGD019288 Neutrophilia (disorder) Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C3711381 BXGD019387 Hereditary Diffuse Leukoencephalopathy with Spheroids Nervous System Diseases
C3873567 BXGD019863 Peripheral neuropathy due to and following chemotherapy Nervous System Diseases
C4021524 BXGD020651 Abnormal adipose tissue morphology
C4021611 BXGD020697 Abnormality of epiphysis morphology
C4022755 BXGD020984 Functional abnormality of the gastrointestinal tract
C4025723 BXGD021757 Abnormal upper motor neuron morphology
C4551583 BXGD023361 Cerebral cortical atrophy
C4551915 BXGD023441 Gait Disturbance, CTCAE
C4552810 BXGD023525 Irritability, CTCAE
C4553743 BXGD023548 Spasticity, CTCAE
C4553765 BXGD023551 Memory Impairment, CTCAE 5.0
C4554063 BXGD023559 Bone Pain, CTCAE 5.0
C4721893 BXGD023783 POLYCYSTIC LIPOMEMBRANOUS OSTEODYSPLASIA WITH SCLEROSING LEUKOENCEPHALOPATHY 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Infections; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
BXGC0002591 Potassium 39.1
BXGC0028471 Monoolein 356.29
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein