Showing entry for Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004885
Protein NameMultifunctional procollagen lysine hydroxylase and glycosyltransferase LH3
Uniport IdO60568
GenePLOD3
Gene Id8985
Domain2OG-FeII_Oxy
Pfam PF03171  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.5 Amino acid metabolism hsa00310 Lysine degradation
1. Metabolism 1.7 Glycan biosynthesis and metabolism hsa00514 Other types of O-glycan biosynthesis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0070831 basement membrane assembly
Biological Process GO:0032870 cellular response to hormone stimulus
Biological Process GO:0030199 collagen fibril organization
Biological Process GO:0032963 collagen metabolic process
Biological Process GO:0001886 endothelial cell morphogenesis
Biological Process GO:0048730 epidermis morphogenesis
Biological Process GO:0046947 hydroxylysine biosynthetic process
Biological Process GO:0001701 in utero embryonic development
Biological Process GO:0060425 lung morphogenesis
Biological Process GO:0021915 neural tube development
Biological Process GO:0017185 peptidyl-lysine hydroxylation
Biological Process GO:0008104 protein localization
Biological Process GO:0006493 protein O-linked glycosylation
Biological Process GO:0042311 vasodilation
molecular function GO:0005506 iron ion binding
molecular function GO:0031418 L-ascorbic acid binding
molecular function GO:0050211 procollagen galactosyltransferase activity
molecular function GO:0033823 procollagen glucosyltransferase activity
molecular function GO:0008475 procollagen-lysine 5-dioxygenase activity
cellular component GO:0062023 collagen-containing extracellular matrix
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005788 endoplasmic reticulum lumen
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0070062 extracellular exosome
cellular component GO:0005615 extracellular space
cellular component GO:0005794 Golgi apparatus
cellular component GO:0005791 rough endoplasmic reticulum
cellular component GO:0005802 trans-Golgi network
Reactome
Pathway Id Pathway Name
R-HSA-1474244 Extracellular matrix organization
R-HSA-1474290 Collagen formation
R-HSA-1650814 Collagen biosynthesis and modifying enzymes
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006287 BXGD000390 Bronchopulmonary Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0009081 BXGD000581 Congenital clubfoot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0009782 BXGD000631 Connective Tissue Diseases Skin and Connective Tissue Diseases
C0011981 BXGD000764 Diaphragmatic Eventration Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0014527 BXGD000923 Epidermolysis Bullosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0016663 BXGD001071 Pathological fracture Wounds and Injuries
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0027092 BXGD001971 Myopia Eye Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029453 BXGD002154 Osteopenia Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0079298 BXGD003073 Epidermolysis Bullosa Simplex Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0086543 BXGD003294 Cataract Eye Diseases
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0155760 BXGD003817 Rupture of artery
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0239234 BXGD004974 Low set ears
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0268524 BXGD005970 gamma-Glutamyltransferase deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0277959 BXGD006487 Coarse hair
C0409338 BXGD008381 Flexion contracture - elbow
C0423798 BXGD008510 Increased tendency to bruise Wounds and Injuries
C0546837 BXGD009343 Malignant neoplasm of esophagus Digestive System Diseases; Neoplasms
C0557874 BXGD009444 Global developmental delay
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0857379 BXGD011148 Abnormality of the pinna
C0940937 BXGD011490 precancerous lesions
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1512409 BXGD013188 Hepatocarcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1834405 BXGD013970 Nail dysplasia Pathological Conditions, Signs and Symptoms
C1839254 BXGD014362 Hypoplasia of the capital femoral epiphysis
C1840077 BXGD014434 Anteverted nostril
C1844704 BXGD014665 Platyspondyly
C1853241 BXGD015321 Flat face
C1854114 BXGD015383 Short nose
C1854718 BXGD015427 J-shaped sella turcica
C1857483 BXGD015707 Decreased palmar creases
C1858085 BXGD015770 Malar flattening
C1859778 BXGD015931 Postnatal growth retardation
C1864715 BXGD016244 Thenar muscle atrophy
C1865014 BXGD016282 Long philtrum
C1865244 BXGD016301 Shallow orbits Eye Diseases
C1866195 BXGD016385 Downturned corners of mouth
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2676285 BXGD017332 Bone Fragility with Contractures, Arterial Rupture, and Deafness Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3279947 BXGD018789 NAIL DISORDER, NONSYNDROMIC CONGENITAL, 9
C4476540 BXGD022824 Dilatation of the cerebral artery Nervous System Diseases; Cardiovascular Diseases
C4707243 BXGD023712 Familial thoracic aortic aneurysm and aortic dissection
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0000764 L-Ascorbic acid 176.12
BXGC0002485 2-Oxopentanedioic acid 146.1
BXGC0003993 Uridine diphosphate 404.16
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein