protein

Showing entry for Eukaryotic translation initiation factor 4E type 2

　　　　　　　　　　　　

General Target Information
BXGT Id	BXGT004886
Protein Name	Eukaryotic translation initiation factor 4E type 2
Uniport Id	O60573
Gene	EIF4E2
Gene Id	9470
Domain	IF4E
Pfam	PF01652
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name
6. Human Diseases	6.12 Drug resistance: Antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance
2. Genetic Information Processing	2.2 Translation	hsa03013	RNA transport
3. Environmental Information Processing	3.2 Signal transduction	hsa04066	HIF-1 signaling pathway
3. Environmental Information Processing	3.2 Signal transduction	hsa04150	mTOR signaling pathway
3. Environmental Information Processing	3.2 Signal transduction	hsa04151	PI3K-Akt signaling pathway
5. Organismal Systems	5.9 Aging	hsa04211	Longevity regulating pathway
5. Organismal Systems	5.2 Endocrine system	hsa04910	Insulin signaling pathway

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0001701	in utero embryonic development
Biological Process	GO:0017148	negative regulation of translation
molecular function	GO:0000340	RNA 7-methylguanosine cap binding
molecular function	GO:0003723	RNA binding
molecular function	GO:0000339	RNA cap binding
molecular function	GO:0008135	translation factor activity, RNA binding
molecular function	GO:0003743	translation initiation factor activity
molecular function	GO:0031625	ubiquitin protein ligase binding
cellular component	GO:0005829	cytosol
cellular component	GO:0016281	eukaryotic translation initiation factor 4F complex
cellular component	GO:0005845	mRNA cap binding complex

Reactome

Pathway Id	Pathway Name
R-HSA-1169408	ISG15 antiviral mechanism
R-HSA-1169410	Antiviral mechanism by IFN-stimulated genes
R-HSA-1280215	Cytokine Signaling in Immune system
R-HSA-168256	Immune System
R-HSA-913531	Interferon Signaling

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0005890	BXGD000345	Body Height
C0006826	BXGD000408	Malignant Neoplasms	Neoplasms
C0007131	BXGD000441	Non-Small Cell Lung Carcinoma	Neoplasms; Respiratory Tract Diseases
C0017636	BXGD001131	Glioblastoma	Neoplasms
C0027651	BXGD002009	Neoplasms	Neoplasms
C0042834	BXGD003004	Vital capacity
C0178874	BXGD004037	Tumor Progression	Pathological Conditions, Signs and Symptoms
C0278878	BXGD006609	Adult Glioblastoma	Neoplasms
C0280100	BXGD006713	Solid Neoplasm	Neoplasms
C0280474	BXGD006748	Childhood Glioblastoma	Neoplasms
C0678222	BXGD009749	Breast Carcinoma	Neoplasms; Skin and Connective Tissue Diseases
C1269955	BXGD012005	Tumor Cell Invasion
C1306459	BXGD012361	Primary malignant neoplasm	Neoplasms
C1621958	BXGD013468	Glioblastoma Multiforme	Neoplasms

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0006368	Formic acid		46.03

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}