Showing entry for UDP-glucuronosyltransferase 1-9


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004889
Protein NameUDP-glucuronosyltransferase 1-9
Uniport IdO60656
GeneUGT1A9
Gene Id54600
DomainUDPGT
Pfam PF00201  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.1 Carbohydrate metabolism hsa00040 Pentose and glucuronate interconversions
1. Metabolism 1.1 Carbohydrate metabolism hsa00053 Ascorbate and aldarate metabolism
1. Metabolism 1.3 Lipid metabolism hsa00140 Steroid hormone biosynthesis
1. Metabolism 1.8 Metabolism of cofactors and vitamins hsa00830 Retinol metabolism
1. Metabolism 1.8 Metabolism of cofactors and vitamins hsa00860 Porphyrin and chlorophyll metabolism
1. Metabolism 1.11 Xenobiotics biodegradation and metabolism hsa00980 Metabolism of xenobiotics by cytochrome P450
1. Metabolism 1.11 Xenobiotics biodegradation and metabolism hsa00982 Drug metabolism - cytochrome P450
1. Metabolism 1.11 Xenobiotics biodegradation and metabolism hsa00983 Drug metabolism - other enzymes
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
6. Human Diseases 6.1 Cancers: Overview hsa05204 Chemical carcinogenesis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0052695 cellular glucuronidation
Biological Process GO:0051552 flavone metabolic process
Biological Process GO:0052696 flavonoid glucuronidation
Biological Process GO:2001030 negative regulation of cellular glucuronidation
Biological Process GO:0045922 negative regulation of fatty acid metabolic process
Biological Process GO:1904224 negative regulation of glucuronosyltransferase activity
Biological Process GO:0019216 regulation of lipid metabolic process
Biological Process GO:0042573 retinoic acid metabolic process
Biological Process GO:0052697 xenobiotic glucuronidation
Biological Process GO:0006805 xenobiotic metabolic process
molecular function GO:0019899 enzyme binding
molecular function GO:0004857 enzyme inhibitor activity
molecular function GO:0015020 glucuronosyltransferase activity
molecular function GO:0046982 protein heterodimerization activity
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0001972 retinoic acid binding
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0016021 integral component of membrane
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-156580 Phase II - Conjugation of compounds
R-HSA-156588 Glucuronidation
R-HSA-1989781 PPARA activates gene expression
R-HSA-211859 Biological oxidations
R-HSA-400206 Regulation of lipid metabolism by PPARalpha
R-HSA-556833 Metabolism of lipids
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002875 BXGD000135 Cooley's anemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0002895 BXGD000152 Anemia, Sickle Cell Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0005283 BXGD000308 beta Thalassemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0008350 BXGD000531 Cholelithiasis Digestive System Diseases
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009806 BXGD000633 Constipation Pathological Conditions, Signs and Symptoms
C0010324 BXGD000663 Crigler Najjar syndrome, type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0010414 BXGD000669 Infection by Cryptococcus neoformans Infections
C0011226 BXGD000704 Hepatitis D Infection Digestive System Diseases; Infections
C0011615 BXGD000738 Dermatitis, Atopic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0013395 BXGD000831 Dyspepsia Pathological Conditions, Signs and Symptoms
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0017205 BXGD001105 Gaucher Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0017551 BXGD001116 Gilbert Disease (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0017921 BXGD001152 Glycogen storage disease type II Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0019193 BXGD001299 Hepatitis, Toxic Digestive System Diseases; Chemically-Induced Disorders
C0020433 BXGD001379 Hyperbilirubinemia Pathological Conditions, Signs and Symptoms
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0022346 BXGD001537 Icterus Pathological Conditions, Signs and Symptoms
C0022660 BXGD001571 Kidney Failure, Acute Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023530 BXGD001683 Leukopenia Hemic and Lymphatic Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0024535 BXGD001785 Malaria, Falciparum Infections
C0027651 BXGD002009 Neoplasms Neoplasms
C0027947 BXGD002061 Neutropenia Hemic and Lymphatic Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0032927 BXGD002381 Precancerous Conditions Neoplasms
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038356 BXGD002747 Stomach Neoplasms Digestive System Diseases; Neoplasms
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0202236 BXGD004086 Triglycerides measurement
C0232865 BXGD004566 Functional proteinuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0242216 BXGD005141 Biliary calculi Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0267797 BXGD005777 Acute hepatitis Digestive System Diseases
C0268138 BXGD005833 Xeroderma Pigmentosum, Complementation Group D Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0268306 BXGD005891 Unconjugated hyperbilirubinemia Pathological Conditions, Signs and Symptoms
C0270210 BXGD006068 Lucey-Driscoll syndrome (disorder) Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0271979 BXGD006283 Thalassemia Intermedia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0278134 BXGD006498 Absence of sensation Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0279606 BXGD006647 Childhood Hepatocellular Carcinoma Digestive System Diseases; Neoplasms
C0279607 BXGD006648 Adult Hepatocellular Carcinoma Digestive System Diseases; Neoplasms
C0311468 BXGD006885 Increased bilirubin level (finding) Pathological Conditions, Signs and Symptoms
C0333980 BXGD006974 Focal Nodular Hyperplasia Digestive System Diseases
C0337438 BXGD007159 Glucose measurement
C0342751 BXGD007542 Generalized glycogen storage disease of infants Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0344395 BXGD007668 Bilirubin measurement
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0376154 BXGD007980 Skin callus Skin and Connective Tissue Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0426576 BXGD008571 Gastrointestinal symptom Pathological Conditions, Signs and Symptoms
C0428474 BXGD008631 Serum LDL cholesterol measurement
C0489786 BXGD009018 Height
C0495706 BXGD009038 elevated blood glucose level
C0523465 BXGD009209 Serum albumin measurement
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0741494 BXGD010035 Elevated total bilirubin
C0857007 BXGD011131 Hyperbilirubinemia, Neonatal Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0860207 BXGD011220 Drug-Induced Liver Disease Digestive System Diseases; Chemically-Induced Disorders
C0947622 BXGD011493 Cholecystolithiasis Digestive System Diseases
C1262760 BXGD011886 Hepatitis, Drug-Induced Digestive System Diseases; Chemically-Induced Disorders
C1287365 BXGD012174 Bilirubin level result
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1314665 BXGD012386 Serum alkaline phosphatase raised
C1443924 BXGD013074 Severe diarrhea Pathological Conditions, Signs and Symptoms
C1445957 BXGD013081 Serum total cholesterol measurement
C1565662 BXGD013402 Acute Kidney Insufficiency Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1611743 BXGD013456 Familial (FPAH)
C1859236 BXGD015867 Prolonged neonatal jaundice Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1866173 BXGD016380 BILIRUBIN, SERUM LEVEL OF, QUANTITATIVE TRAIT LOCUS 1
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2609414 BXGD017182 Acute kidney injury Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2931132 BXGD017963 Crigler Najjar syndrome, type 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C2985280 BXGD018223 Blood Protein Measurement
C3658290 BXGD019256 Drug-Induced Acute Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C4277682 BXGD022376 Chemical and Drug Induced Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C4279912 BXGD022378 Chemically-Induced Liver Toxicity Digestive System Diseases; Chemically-Induced Disorders
C4303163 BXGD022553 Autoimmune hepatitis type 2
C4721579 BXGD023759 Secondary malignant neoplasm of colon and/or rectum Digestive System Diseases; Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000126 4-Ethylphenol 122.16
BXGC0000130 Estradiol 272.38
BXGC0000332 Fisetin 286.24
BXGC0000363 Galangin 270.24
BXGC0000497 Vanillin 152.15
BXGC0000528 Salicylic acid 138.12
BXGC0000533 trans-Cinnamyl alcohol 134.18
BXGC0000537 Acetylsalicylic acid 180.16
BXGC0000573 Dantron 240.21
BXGC0000663 Papain 206.28
BXGC0000819 Nopol 166.26
BXGC0001238 3-Methoxy-4-hydroxyphenylacetic acid 182.17
BXGC0001778 Scutellarein 286.24
BXGC0001879 Chlorogenic acid 354.31
BXGC0001881 Chrysophanol 254.24
BXGC0001899 Daidzein 254.24
BXGC0002627 17alpha-ethynylestradiol 296.4
BXGC0002806 Shikimic acid 174.15
BXGC0003485 Naphthalen-1-ol 144.17
BXGC0003707 Estrogen 268.36
BXGC0003773 Estriol 288.38
BXGC0003949 Thymunic acid 150.22
BXGC0004378 3-Hydroxyflavone 238.24
BXGC0004560 Benzoic acid 122.12
BXGC0004565 Benzyl alcohol 108.14
BXGC0004577 4-tert-Butylphenol 150.22
BXGC0004591 4-Methylphenol 108.14
BXGC0004707 4'-Hydroxyacetophenone 136.15
BXGC0004711 4-Hydroxybenzoic acid 138.12
BXGC0004712 Methylparaben 152.15
BXGC0004713 Ethylparaben 166.17
BXGC0005624 Genistein 270.24
BXGC0005683 Quercetin 302.24
BXGC0005745 Irilone 298.25
BXGC0005750 2,6-Di-tert-butyl-4-methylphenol 220.35
BXGC0005756 Propyl gallate 212.2
BXGC0005879 Eugenol 164.2
BXGC0006291 Scopoletin 192.17
BXGC0006362 Estrone 270.37
BXGC0006919 (-)-trans-Carveol 152.23
BXGC0006923 D-Citronellol 156.27
BXGC0007029 Emodin 270.24
BXGC0007526 (+)-Neomenthol 156.27
BXGC0007528 p-Menthan-3-ol 156.27
BXGC0007535 5-Isopropyl-2-methylphenol 150.22
BXGC0012243 Ukonan D 151.16
BXGC0013544 Naphthalen-1-Amine 143.07
BXGC0019628 mono-(2-ethylhexyl)phthalate 278.15
BXGC0022978 Biphenyl-4-Amine 169.09
BXGC0025862 Levothyroxine 776.69
BXGC0026391 Naloxone 327.15
BXGC0027725 (-)-Citronellol 156.15
BXGC0030901 Morphine 285.14
BXGC0034783 Doxorubicin 543.17
BXGC0035676 morphine-3-glucuronide 461.17
BXGC0036805 Butylated Hydroxyanisole 180.12
BXGC0037718 Ethacrynic Acid 302.01
BXGC0037915 isoborneol 154.14
BXGC0039397 Athraquinones A 240.04
BXGC0040462 Aminosalicylic Acid 153.04
BXGC0042222 Propranolol 259.16
BXGC0042460 Betanaphthol 144.06
BXGC0047169 Hymecromone 176.05
BXGC0049633 4-Aminophenol 109.05
BXGC0052712 Anthraflavicacid 240.04
BXGC0053114 Propylparaben 180.08
BXGC0053494 Quinizarin 240.04
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein