Showing entry for Core histone macro-H2A.1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005117
Protein NameCore histone macro-H2A.1
Uniport IdO75367
GeneMACROH2A1
Gene Id9555
DomainHistone; Histone_H2A_C; Macro
Pfam PF00125   PF16211   PF01661  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.2 Cell growth and death hsa04217 Necroptosis
6. Human Diseases 6.5 Substance dependence hsa05034 Alcoholism
6. Human Diseases 6.3 Immune diseases hsa05322 Systemic lupus erythematosus
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006325 chromatin organization
Biological Process GO:0006342 chromatin silencing
Biological Process GO:0007549 dosage compensation
Biological Process GO:0071169 establishment of protein localization to chromatin
Biological Process GO:1902750 negative regulation of cell cycle G2/M phase transition
Biological Process GO:0045814 negative regulation of gene expression, epigenetic
Biological Process GO:0061086 negative regulation of histone H3-K27 methylation
Biological Process GO:0051572 negative regulation of histone H3-K4 methylation
Biological Process GO:0033128 negative regulation of histone phosphorylation
Biological Process GO:1904815 negative regulation of protein localization to chromosome, telomeric region
Biological Process GO:0071901 negative regulation of protein serine/threonine kinase activity
Biological Process GO:1902883 negative regulation of response to oxidative stress
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:1901837 negative regulation of transcription of nucleolar large rRNA by RNA polymerase I
Biological Process GO:0006334 nucleosome assembly
Biological Process GO:1903226 positive regulation of endodermal cell differentiation
Biological Process GO:0045815 positive regulation of gene expression, epigenetic
Biological Process GO:0045618 positive regulation of keratinocyte differentiation
Biological Process GO:0034184 positive regulation of maintenance of mitotic sister chromatid cohesion
Biological Process GO:1902884 positive regulation of response to oxidative stress
Biological Process GO:0040029 regulation of gene expression, epigenetic
Biological Process GO:0019216 regulation of lipid metabolic process
Biological Process GO:1902882 regulation of response to oxidative stress
molecular function GO:0031490 chromatin DNA binding
molecular function GO:0003677 DNA binding
molecular function GO:0010385 double-stranded methylated DNA binding
molecular function GO:0019899 enzyme binding
molecular function GO:0031492 nucleosomal DNA binding
molecular function GO:1990841 promoter-specific chromatin binding
molecular function GO:0046982 protein heterodimerization activity
molecular function GO:0019901 protein kinase binding
molecular function GO:0030291 protein serine/threonine kinase inhibitor activity
molecular function GO:0000182 rDNA binding
molecular function GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
molecular function GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
molecular function GO:0000976 transcription regulatory region sequence-specific DNA binding
cellular component GO:0001740 Barr body
cellular component GO:0000793 condensed chromosome
cellular component GO:0070062 extracellular exosome
cellular component GO:0000790 nuclear chromatin
cellular component GO:0000228 nuclear chromosome
cellular component GO:0000784 nuclear chromosome, telomeric region
cellular component GO:0005730 nucleolus
cellular component GO:0005654 nucleoplasm
cellular component GO:0000786 nucleosome
cellular component GO:0005634 nucleus
cellular component GO:0005721 pericentric heterochromatin
cellular component GO:0001739 sex chromatin
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023794 BXGD001700 Lipoidosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024131 BXGD001736 Lupus Vulgaris Infections; Skin and Connective Tissue Diseases
C0024138 BXGD001738 Lupus Erythematosus, Discoid Skin and Connective Tissue Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0162298 BXGD003933 Joint stiffness Musculoskeletal Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0200635 BXGD004041 Lymphocyte Count measurement
C0221355 BXGD004447 Macrocephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0221357 BXGD004449 Brachydactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0409974 BXGD008401 Lupus Erythematosus Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases; Immune System Diseases
C0410702 BXGD008447 Adolescent idiopathic scoliosis Musculoskeletal Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1512409 BXGD013188 Hepatocarcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1623038 BXGD013475 Cirrhosis Pathological Conditions, Signs and Symptoms
C1836193 BXGD014093 Synostosis of carpal bones
C1837461 BXGD014234 SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
C1850049 BXGD015101 Clinodactyly of the 5th finger
C1861313 BXGD016028 Synostosis, Carpal, with Dysplastic Elbow Joints and Brachydactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2749463 BXGD017620 Aplasia/Hypoplasia of the radius
C4021742 BXGD020750 Abnormality of the humerus
C4025662 BXGD021716 Abnormality of the ulna
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002722 Nitrate 62
BXGC0004275 Acetaldehyde 44.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein