Showing entry for Short-chain dehydrogenase/reductase 3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005164
Protein NameShort-chain dehydrogenase/reductase 3
Uniport IdO75911
GeneDHRS3
Gene Id9249
Domainadh_short
Pfam PF00106  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.8 Metabolism of cofactors and vitamins hsa00830 Retinol metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0060349 bone morphogenesis
Biological Process GO:0060411 cardiac septum morphogenesis
Biological Process GO:0048387 negative regulation of retinoic acid receptor signaling pathway
Biological Process GO:0003151 outflow tract morphogenesis
Biological Process GO:0030278 regulation of ossification
Biological Process GO:0048385 regulation of retinoic acid receptor signaling pathway
Biological Process GO:0001523 retinoid metabolic process
Biological Process GO:0042572 retinol metabolic process
Biological Process GO:0060021 roof of mouth development
Biological Process GO:0007601 visual perception
molecular function GO:0009055 electron transfer activity
molecular function GO:0052650 NADP-retinol dehydrogenase activity
molecular function GO:0000166 nucleotide binding
molecular function GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
molecular function GO:0004745 retinol dehydrogenase activity
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0016021 integral component of membrane
cellular component GO:0005811 lipid droplet
cellular component GO:0042622 photoreceptor outer segment membrane
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-2187335 The retinoid cycle in cones (daylight vision)
R-HSA-2187338 Visual phototransduction
R-HSA-372790 Signaling by GPCR
R-HSA-388396 GPCR downstream signalling
R-HSA-418594 G alpha (i) signalling events
R-HSA-5362517 Signaling by Retinoic Acid
R-HSA-5365859 RA biosynthesis pathway
R-HSA-9006931 Signaling by Nuclear Receptors
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0014772 BXGD000948 Red Blood Cell Count measurement
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0406704 BXGD008364 Rudiger syndrome 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Stomatognathic Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1863204 BXGD016156 ADULT SYNDROME Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Stomatognathic Diseases
C1864233 BXGD016219 ENDPLATE ACETYLCHOLINESTERASE DEFICIENCY (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0047568 Retinol 286.23
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein