Showing entry for Inhibitor of nuclear factor kappa-B kinase subunit beta


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005270
Protein NameInhibitor of nuclear factor kappa-B kinase subunit beta
Uniport IdO88351
GeneIkbkb
Gene Id16150
DomainIKBKB_SDD; IKKbetaNEMObind; Pkinase
Pfam PF18397   PF12179   PF00069  
OrganismMus musculus (Mouse)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0001782 B cell homeostasis
Biological Process GO:0071356 cellular response to tumor necrosis factor
Biological Process GO:0030866 cortical actin cytoskeleton organization
Biological Process GO:0007249 I-kappaB kinase/NF-kappaB signaling
Biological Process GO:0007252 I-kappaB phosphorylation
Biological Process GO:0070498 interleukin-1-mediated signaling pathway
Biological Process GO:1903347 negative regulation of bicellular tight junction assembly
Biological Process GO:0035509 negative regulation of myosin-light-chain-phosphatase activity
Biological Process GO:0031175 neuron projection development
Biological Process GO:0018105 peptidyl-serine phosphorylation
Biological Process GO:2001259 positive regulation of cation channel activity
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
Biological Process GO:1901216 positive regulation of neuron death
Biological Process GO:0010976 positive regulation of neuron projection development
Biological Process GO:0051092 positive regulation of NF-kappaB transcription factor activity
Biological Process GO:0010765 positive regulation of sodium ion transport
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0072659 protein localization to plasma membrane
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:1903140 regulation of establishment of endothelial barrier
Biological Process GO:0042325 regulation of phosphorylation
Biological Process GO:0061847 response to cholecystokinin
Biological Process GO:0033209 tumor necrosis factor-mediated signaling pathway
molecular function GO:0005524 ATP binding
molecular function GO:0042802 identical protein binding
molecular function GO:0008384 IkappaB kinase activity
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0046982 protein heterodimerization activity
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0004672 protein kinase activity
molecular function GO:0019901 protein kinase binding
molecular function GO:0019903 protein phosphatase binding
molecular function GO:0004674 protein serine/threonine kinase activity
molecular function GO:0097110 scaffold protein binding
molecular function GO:1990459 transferrin receptor binding
cellular component GO:0035631 CD40 receptor complex
cellular component GO:0005737 cytoplasm
cellular component GO:0009898 cytoplasmic side of plasma membrane
cellular component GO:0005829 cytosol
cellular component GO:0008385 IkappaB kinase complex
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0045121 membrane raft
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0021676 Withaferin A 470.27
BXGC0022098 Withanolide A 470.27
BXGC0040222 Xerophilusin F 404.18
BXGC0040364 Artesunate 384.18
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein