Showing entry for Disabled homolog 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005284
Protein NameDisabled homolog 2
Uniport IdO88797
GeneDab2
Gene Id79128
DomainPID
Pfam PF00640  
OrganismRattus norvegicus (Rat)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007257 activation of JUN kinase activity
Biological Process GO:0006915 apoptotic process
Biological Process GO:0000904 cell morphogenesis involved in differentiation
Biological Process GO:0071364 cellular response to epidermal growth factor stimulus
Biological Process GO:0071560 cellular response to transforming growth factor beta stimulus
Biological Process GO:0048268 clathrin coat assembly
Biological Process GO:0007492 endoderm development
Biological Process GO:0007588 excretion
Biological Process GO:0071425 hematopoietic stem cell proliferation
Biological Process GO:0001701 in utero embryonic development
Biological Process GO:0035026 leading edge cell differentiation
Biological Process GO:0030099 myeloid cell differentiation
Biological Process GO:0060766 negative regulation of androgen receptor signaling pathway
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0090090 negative regulation of canonical Wnt signaling pathway
Biological Process GO:0030308 negative regulation of cell growth
Biological Process GO:0050680 negative regulation of epithelial cell proliferation
Biological Process GO:0070373 negative regulation of ERK1 and ERK2 cascade
Biological Process GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Biological Process GO:0010977 negative regulation of neuron projection development
Biological Process GO:0032091 negative regulation of protein binding
Biological Process GO:1903077 negative regulation of protein localization to plasma membrane
Biological Process GO:0045892 negative regulation of transcription, DNA-templated
Biological Process GO:0006907 pinocytosis
Biological Process GO:0032349 positive regulation of aldosterone biosynthetic process
Biological Process GO:2000860 positive regulation of aldosterone secretion
Biological Process GO:0045785 positive regulation of cell adhesion
Biological Process GO:0030335 positive regulation of cell migration
Biological Process GO:2000370 positive regulation of clathrin-dependent endocytosis
Biological Process GO:2000643 positive regulation of early endosome to late endosome transport
Biological Process GO:0045807 positive regulation of endocytosis
Biological Process GO:0010718 positive regulation of epithelial to mesenchymal transition
Biological Process GO:2001046 positive regulation of integrin-mediated signaling pathway
Biological Process GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
Biological Process GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Biological Process GO:0001934 positive regulation of protein phosphorylation
Biological Process GO:0002092 positive regulation of receptor internalization
Biological Process GO:0001921 positive regulation of receptor recycling
Biological Process GO:0060391 positive regulation of SMAD protein signal transduction
Biological Process GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter
Biological Process GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
Biological Process GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway
Biological Process GO:0015031 protein transport
Biological Process GO:0006898 receptor-mediated endocytosis
Biological Process GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity
Biological Process GO:1902074 response to salt
Biological Process GO:0048545 response to steroid hormone
Biological Process GO:0016055 Wnt signaling pathway
molecular function GO:0035612 AP-2 adaptor complex binding
molecular function GO:0038024 cargo receptor activity
molecular function GO:0035615 clathrin adaptor activity
molecular function GO:0030276 clathrin binding
molecular function GO:0005178 integrin binding
molecular function GO:0050750 low-density lipoprotein particle receptor binding
molecular function GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
molecular function GO:0035091 phosphatidylinositol binding
molecular function GO:0008022 protein C-terminus binding
molecular function GO:0046332 SMAD binding
cellular component GO:0016324 apical plasma membrane
cellular component GO:0005905 clathrin-coated pit
cellular component GO:0030136 clathrin-coated vesicle
cellular component GO:0030665 clathrin-coated vesicle membrane
cellular component GO:0030132 clathrin coat of coated pit
cellular component GO:0005737 cytoplasm
cellular component GO:0005634 nucleus
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein