Showing entry for Nuclear factor of activated T-cells, cytoplasmic 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005290
Protein NameNuclear factor of activated T-cells, cytoplasmic 1
Uniport IdO88942
GeneNfatc1
Gene Id
DomainRHD_dimer; RHD_DNA_bind
Pfam PF16179   PF00554  
OrganismMus musculus (Mouse)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0003180 aortic valve morphogenesis
Biological Process GO:0002337 B-1a B cell differentiation
Biological Process GO:0060854 branching involved in lymph vessel morphogenesis
Biological Process GO:0033173 calcineurin-NFAT signaling cascade
Biological Process GO:0006816 calcium ion transport
Biological Process GO:0001816 cytokine production
Biological Process GO:0001837 epithelial to mesenchymal transition
Biological Process GO:0000082 G1/S transition of mitotic cell cycle
Biological Process GO:0007507 heart development
Biological Process GO:0061384 heart trabecula morphogenesis
Biological Process GO:0003179 heart valve morphogenesis
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0001946 lymphangiogenesis
Biological Process GO:0045668 negative regulation of osteoblast differentiation
Biological Process GO:2000647 negative regulation of stem cell proliferation
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:1905064 negative regulation of vascular associated smooth muscle cell differentiation
Biological Process GO:0030316 osteoclast differentiation
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0003184 pulmonary valve morphogenesis
Biological Process GO:0042634 regulation of hair cycle
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0014883 transition between fast and slow fiber
Biological Process GO:0060412 ventricular septum morphogenesis
molecular function GO:0003682 chromatin binding
molecular function GO:0003677 DNA binding
molecular function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
molecular function GO:0003700 DNA-binding transcription factor activity
molecular function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
molecular function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
molecular function GO:0048273 mitogen-activated protein kinase p38 binding
molecular function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
molecular function GO:0001225 RNA polymerase II transcription coactivator binding
molecular function GO:0001085 RNA polymerase II transcription factor binding
molecular function GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
molecular function GO:0043565 sequence-specific DNA binding
molecular function GO:1990837 sequence-specific double-stranded DNA binding
molecular function GO:0008134 transcription factor binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0016604 nuclear body
cellular component GO:0000790 nuclear chromatin
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0005667 transcription regulator complex
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003198 trans-2-Methoxycinnamaldehyde 162.19
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein