Showing entry for Interleukin-18 receptor accessory protein


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005364
Protein NameInterleukin-18 receptor accessory protein
Uniport IdO95256
GeneIL18RAP
Gene Id8807
DomainIg_2; Ig_6; TIR
Pfam PF13895   PF18452   PF01582  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04060 Cytokine-cytokine receptor interaction
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04061 Viral protein interaction with cytokine and cytokine receptor
6. Human Diseases 6.3 Immune diseases hsa05321 Inflammatory bowel disease (IBD)
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0008283 cell population proliferation
Biological Process GO:0070301 cellular response to hydrogen peroxide
Biological Process GO:0006955 immune response
Biological Process GO:0006954 inflammatory response
Biological Process GO:0032609 interferon-gamma production
Biological Process GO:0035655 interleukin-18-mediated signaling pathway
Biological Process GO:0032635 interleukin-6 production
Biological Process GO:0042119 neutrophil activation
Biological Process GO:0045954 positive regulation of natural killer cell mediated cytotoxicity
Biological Process GO:0051092 positive regulation of NF-kappaB transcription factor activity
Biological Process GO:0035744 T-helper 1 cell cytokine production
molecular function GO:0042008 interleukin-18 receptor activity
molecular function GO:0050135 NAD(P)+ nucleosidase activity
molecular function GO:0061809 NAD+ nucleotidase, cyclic ADP-ribose generating
cellular component GO:0045092 interleukin-18 receptor complex
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System
R-HSA-446652 Interleukin-1 family signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-9012546 Interleukin-18 signaling
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0004763 BXGD000289 Barrett Esophagus Digestive System Diseases; Neoplasms
C0005956 BXGD000356 Bone Marrow Diseases Hemic and Lymphatic Diseases
C0006413 BXGD000397 Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007570 BXGD000467 Celiac Disease Digestive System Diseases; Nutritional and Metabolic Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0014852 BXGD000958 Esophageal Diseases Digestive System Diseases
C0018213 BXGD001187 Graves Disease Eye Diseases; Immune System Diseases; Endocrine System Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0037928 BXGD002713 Spinal Cord Diseases Nervous System Diseases
C0040128 BXGD002844 Thyroid Diseases Endocrine System Diseases
C0149721 BXGD003349 Left Ventricular Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0158266 BXGD003878 Intervertebral Disc Degeneration Musculoskeletal Diseases
C0200638 BXGD004043 Eosinophil count procedure
C0200641 BXGD004044 Blood basophil count (lab test)
C0202236 BXGD004086 Triglycerides measurement
C0221775 BXGD004480 Lumbar disc disease Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0263874 BXGD005352 Degeneration of lumbar intervertebral disc Musculoskeletal Diseases
C0278764 BXGD006581 Adult Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0278879 BXGD006610 Childhood Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0391826 BXGD008013 Lhermitte-Duclos disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms
C0677607 BXGD009721 Hashimoto Disease Endocrine System Diseases
C0856825 BXGD011118 Acute GVH disease Immune System Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1136249 BXGD011715 Mental Retardation, X-Linked Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1275122 BXGD012060 Familial multiple trichoepitheliomata Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Skin and Connective Tissue Diseases
C1527304 BXGD013266 Allergic Reaction Immune System Diseases
C1868683 BXGD016526 B-CELL MALIGNANCY, LOW-GRADE
C4553157 BXGD023536 Interleukin 1 Receptor-Like 1 Measurement
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003705 Chloride 35.45
BXGC0018397 beta-1,4-mannan 180.06
BXGC0050194 alpha-D-Mannose 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein