Showing entry for High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005366
Protein NameHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
Uniport IdO95263
GenePDE8B
Gene Id8622
DomainPAS_9; PDE8; PDEase_I
Pfam PF13426   PF08629   PF00233  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.4 Nucleotide metabolism hsa00230 Purine metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
5. Organismal Systems 5.2 Endocrine system hsa04927 Cortisol synthesis and secretion
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04934 Cushing syndrome
6. Human Diseases 6.5 Substance dependence hsa05032 Morphine addiction
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006198 cAMP catabolic process
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
molecular function GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
molecular function GO:0046872 metal ion binding
cellular component GO:0005829 cytosol
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-372790 Signaling by GPCR
R-HSA-388396 GPCR downstream signalling
R-HSA-418555 G alpha (s) signalling events
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001430 BXGD000054 Adenoma Neoplasms
C0001624 BXGD000067 Adrenal Gland Neoplasms Neoplasms; Endocrine System Diseases
C0001627 BXGD000068 Congenital adrenal hyperplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0004782 BXGD000292 Basal Ganglia Diseases Nervous System Diseases
C0010481 BXGD000673 Cushing Syndrome Endocrine System Diseases
C0011168 BXGD000700 Deglutition Disorders Digestive System Diseases; Otorhinolaryngologic Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0013362 BXGD000817 Dysarthria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0015371 BXGD000978 Extrapyramidal Disorders Nervous System Diseases
C0015672 BXGD001011 Fatigue Pathological Conditions, Signs and Symptoms
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020550 BXGD001429 Hyperthyroidism Endocrine System Diseases
C0020619 BXGD001447 Hypogonadism Endocrine System Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0025267 BXGD001845 Multiple Endocrine Neoplasia Type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Endocrine System Diseases
C0026650 BXGD001913 Movement Disorders Nervous System Diseases
C0026837 BXGD001937 Muscle Rigidity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027662 BXGD002015 Multiple Endocrine Neoplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Endocrine System Diseases
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0030421 BXGD002218 Paraganglioma Neoplasms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0031511 BXGD002304 Pheochromocytoma Neoplasms
C0040128 BXGD002844 Thyroid Diseases Endocrine System Diseases
C0086439 BXGD003284 Hypokinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151564 BXGD003440 Cogwheel Rigidity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0151786 BXGD003475 Muscle Weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0152459 BXGD003600 Linear atrophy Pathological Conditions, Signs and Symptoms
C0200638 BXGD004043 Eosinophil count procedure
C0202230 BXGD004084 Thyroid stimulating hormone measurement
C0205682 BXGD004105 Waist-Hip Ratio
C0206667 BXGD004228 Adrenal Cortical Adenoma Neoplasms; Endocrine System Diseases
C0231519 BXGD004495 Gegenhalten Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0233565 BXGD004590 Bradykinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0233608 BXGD004595 Catatonic Rigidity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0234979 BXGD004707 Dysdiadochokinesis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0238198 BXGD004893 Gastrointestinal Stromal Tumors Digestive System Diseases; Neoplasms
C0239325 BXGD004977 Extensor Rigidity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0240952 BXGD005066 Dysarthria, Scanning Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0242422 BXGD005163 Parkinsonian Disorders Nervous System Diseases
C0270715 BXGD006089 Degenerative Diseases, Central Nervous System Nervous System Diseases
C0271790 BXGD006259 Subclinical hypothyroidism Endocrine System Diseases
C0277821 BXGD006478 Extrapyramidal Rigidity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0342443 BXGD007481 Adrenal Cushing's syndrome Endocrine System Diseases
C0349588 BXGD007933 Short stature
C0423757 BXGD008504 Thin skin
C0441683 BXGD008809 Hormone measurement
C0454596 BXGD008842 Dysarthria, Spastic Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0454597 BXGD008843 Dysarthria, Flaccid Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0454598 BXGD008844 Dysarthria, Mixed Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0541794 BXGD009262 Skeletal muscle atrophy
C0575081 BXGD009512 Gait abnormality Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0696098 BXGD009856 Blood thyroid stimulating hormone analysis
C0750951 BXGD010262 Lenticulostriate Disorders Nervous System Diseases
C0751733 BXGD010569 Degenerative Diseases, Spinal Cord Nervous System Diseases
C1304508 BXGD012341 Spindle cell hemangioma Neoplasms
C1320474 BXGD012425 Nuchal Rigidity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1390474 BXGD012969 Increased susceptibility to fractures
C1563666 BXGD013383 Dysarthria, Guttural Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1611743 BXGD013456 Familial (FPAH)
C1621895 BXGD013466 Adrenal hyperplasia Pathological Conditions, Signs and Symptoms; Neoplasms; Endocrine System Diseases
C1836694 BXGD014150 Striatal Degeneration, Autosomal Dominant Pathological Conditions, Signs and Symptoms
C1836696 BXGD014151 Lower limb hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1847319 BXGD014858 PARAGANGLIOMA AND GASTRIC STROMAL SARCOMA Digestive System Diseases; Neoplasms
C1850573 BXGD015154 Slender build Pathological Conditions, Signs and Symptoms
C1854494 BXGD015409 Slow progression
C1858592 BXGD015812 Carney Triad Digestive System Diseases; Neoplasms; Respiratory Tract Diseases
C1968851 BXGD016741 Pigmented micronodular adrenocortical disease
C1997262 BXGD016860 Hypothyroidism in pregnancy Endocrine System Diseases
C2242456 BXGD016972 thyroid function
C2362324 BXGD017091 Pediatric Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C2919142 BXGD017867 Short Stature, CTCAE
C3280094 BXGD018800 PIGMENTED NODULAR ADRENOCORTICAL DISEASE, PRIMARY, 3
C4022417 BXGD020898 Degeneration of the striatum Pathological Conditions, Signs and Symptoms
C4024947 BXGD021494 Symmetric lesions of the basal ganglia
C4025651 BXGD021712 Increased circulating cortisol level
C4304832 BXGD022585 Primary pigmented nodular adrenocortical disease
C4310808 BXGD022674 STRIATAL DEGENERATION, AUTOSOMAL DOMINANT 1
C4331029 BXGD022809 Primary Pigmented Nodular Adrenal Dysplasia
C4551683 BXGD023389 Adrenal Gland Pheochromocytoma Neoplasms; Endocrine System Diseases
C4551915 BXGD023441 Gait Disturbance, CTCAE
C4552766 BXGD023523 Miscarriage Female Urogenital Diseases and Pregnancy Complications
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0001502 Caffeine 194.19
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein