Showing entry for Glutamate dehydrogenase 1, mitochondrial


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005517
Protein NameGlutamate dehydrogenase 1, mitochondrial
Uniport IdP00367
GeneGLUD1
Gene Id2746
DomainELFV_dehydrog; ELFV_dehydrog_N
Pfam PF00208   PF02812  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.5 Amino acid metabolism hsa00220 Arginine biosynthesis
1. Metabolism 1.5 Amino acid metabolism hsa00250 Alanine, aspartate and glutamate metabolism
1. Metabolism 1.6 Metabolism of other amino acids hsa00471 D-Glutamine and D-glutamate metabolism
1. Metabolism 1.2 Energy metabolism hsa00910 Nitrogen metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
1. Metabolism 1.0 Global and overview maps hsa01200 Carbon metabolism
4. Cellular Processes 4.2 Cell growth and death hsa04217 Necroptosis
5. Organismal Systems 5.5 Excretory system hsa04964 Proximal tubule bicarbonate reclamation
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0008652 cellular amino acid biosynthetic process
Biological Process GO:0006537 glutamate biosynthetic process
Biological Process GO:0006538 glutamate catabolic process
Biological Process GO:0006541 glutamine metabolic process
Biological Process GO:0032024 positive regulation of insulin secretion
Biological Process GO:0021762 substantia nigra development
Biological Process GO:0072350 tricarboxylic acid metabolic process
molecular function GO:0043531 ADP binding
molecular function GO:0005524 ATP binding
molecular function GO:0004352 glutamate dehydrogenase (NAD+) activity
molecular function GO:0005525 GTP binding
molecular function GO:0042802 identical protein binding
molecular function GO:0070728 leucine binding
molecular function GO:0070403 NAD+ binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005759 mitochondrial matrix
cellular component GO:0005739 mitochondrion
molecular function GO:0004353 glutamate dehydrogenase NAD(P)+ activity
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1592230 Mitochondrial biogenesis
R-HSA-1852241 Organelle biogenesis and maintenance
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis
R-HSA-71291 Metabolism of amino acids and derivatives
R-HSA-8964539 Glutamate and glutamine metabolism
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002875 BXGD000135 Cooley's anemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0005283 BXGD000308 beta Thalassemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007786 BXGD000486 Brain Ischemia Nervous System Diseases; Cardiovascular Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010709 BXGD000689 Cyst Pathological Conditions, Signs and Symptoms; Neoplasms
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014550 BXGD000930 Myoclonic Epilepsy Nervous System Diseases
C0014553 BXGD000931 Absence Epilepsy Nervous System Diseases
C0014556 BXGD000932 Epilepsy, Temporal Lobe Nervous System Diseases
C0015652 BXGD001010 Fascioliasis Digestive System Diseases; Infections
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0017536 BXGD001114 Giardiasis Digestive System Diseases; Infections
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0019151 BXGD001290 Hepatic Encephalopathy Digestive System Diseases; Nutritional and Metabolic Diseases; Nervous System Diseases
C0020459 BXGD001394 Hyperinsulinism Nutritional and Metabolic Diseases
C0020501 BXGD001409 Primary Hyperoxaluria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0020615 BXGD001445 Hypoglycemia Nutritional and Metabolic Diseases
C0020617 BXGD001446 Hypoglycemic coma Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Nervous System Diseases; Endocrine System Diseases
C0021345 BXGD001497 Infectious Mononucleosis Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0026351 BXGD001900 Moderate intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026650 BXGD001913 Movement Disorders Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0035126 BXGD002509 Reperfusion Injury Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0035372 BXGD002544 Rett Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0220994 BXGD004357 Hyperammonemia Pathological Conditions, Signs and Symptoms
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0265354 BXGD005529 CHARGE Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0268576 BXGD005994 Hyperleucinemia
C0270824 BXGD006113 Visual seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0271710 BXGD006245 Reactive hypoglycemia Nutritional and Metabolic Diseases
C0275524 BXGD006376 Coinfection Infections
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0343386 BXGD007620 Clostridium difficile infection Infections
C0345905 BXGD007746 Intrahepatic Cholangiocarcinoma Neoplasms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0474808 BXGD008959 Follicular neoplasm Neoplasms
C0557874 BXGD009444 Global developmental delay
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0687720 BXGD009844 Central Diabetes Insipidus Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0877056 BXGD011334 Hypoglycemic seizures Nutritional and Metabolic Diseases
C1257963 BXGD011818 Endogenous Hyperinsulinism Nutritional and Metabolic Diseases
C1257964 BXGD011819 Exogenous Hyperinsulinism Nutritional and Metabolic Diseases
C1257965 BXGD011820 Compensatory Hyperinsulinemia Nutritional and Metabolic Diseases
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1411966 BXGD013047 Clostridium; difficile (disorder)
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1720983 BXGD013698 Channelopathies Pathological Conditions, Signs and Symptoms
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1846142 BXGD014785 HOYERAAL-HREIDARSSON SYNDROME Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Nervous System Diseases; Mental Disorders; Hemic and Lymphatic Diseases; Behavior and Behavior Mechanisms
C1847555 BXGD014875 Hyperinsulinemic hypoglycemia, familial, 6 Nutritional and Metabolic Diseases
C1864903 BXGD016270 Hyperinsulinemic hypoglycemia Nutritional and Metabolic Diseases
C1864954 BXGD016278 Fasting hyperinsulinemia Nutritional and Metabolic Diseases
C1876187 BXGD016565 TUMORAL CALCINOSIS, HYPERPHOSPHATEMIC, FAMILIAL Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3805278 BXGD019474 Extrahepatic Cholangiocarcinoma Neoplasms
C3888018 BXGD019942 Congenital Hyperinsulinism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases
C4021552 BXGD020668 Asymptomatic hyperammonemia Pathological Conditions, Signs and Symptoms
C4022915 BXGD021036 Increased urine alpha-ketoglutarate concentration
C4023476 BXGD021197 EEG with generalized epileptiform discharges
C4025790 BXGD021791 Specific learning disability
C4316903 BXGD022711 Absence Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4551976 BXGD023460 HYPOTRICHOSIS 1
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4728082 BXGD023886 Severe hypoglycaemia
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0006162 L-Glutamic acid 147.13
BXGC0048845 Guanosine Triphosphate 522.99
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein