Showing entry for Dihydrofolate reductase



                       
General Target Information
BXGT IdBXGT005521
Protein NameDihydrofolate reductase
Uniport IdP00375
GeneDhfr
Gene Id13361
DomainDHFR_1
Pfam PF00186  
OrganismMus musculus (Mouse)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0031103 axon regeneration
Biological Process GO:0046452 dihydrofolate metabolic process
Biological Process GO:0046655 folic acid metabolic process
Biological Process GO:0017148 negative regulation of translation
Biological Process GO:0006730 one-carbon metabolic process
Biological Process GO:0055114 oxidation-reduction process
Biological Process GO:0051000 positive regulation of nitric-oxide synthase activity
Biological Process GO:2000121 regulation of removal of superoxide radicals
Biological Process GO:0031427 response to methotrexate
Biological Process GO:0035094 response to nicotine
Biological Process GO:0006729 tetrahydrobiopterin biosynthetic process
Biological Process GO:0046654 tetrahydrofolate biosynthetic process
Biological Process GO:0046653 tetrahydrofolate metabolic process
molecular function GO:0004146 dihydrofolate reductase activity
molecular function GO:0051871 dihydrofolic acid binding
molecular function GO:0008144 drug binding
molecular function GO:0005542 folic acid binding
molecular function GO:0051870 methotrexate binding
molecular function GO:0003729 mRNA binding
molecular function GO:0050661 NADP binding
molecular function GO:0070402 NADPH binding
molecular function GO:1990825 sequence-specific mRNA binding
molecular function GO:0000900 translation repressor activity, mRNA regulatory element binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005739 mitochondrion
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0000759 Arabinan 243.22
BXGC0034783 Doxorubicin 543.17
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein