Showing entry for Dihydrofolate reductase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005522
Protein NameDihydrofolate reductase
Uniport IdP00376
GeneDHFR
Gene Id508809
DomainDHFR_1
Pfam PF00186  
OrganismBos taurus (Bovine)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0046452 dihydrofolate metabolic process
Biological Process GO:0046655 folic acid metabolic process
Biological Process GO:0006730 one-carbon metabolic process
Biological Process GO:0031427 response to methotrexate
Biological Process GO:0046654 tetrahydrofolate biosynthetic process
Biological Process GO:0046653 tetrahydrofolate metabolic process
molecular function GO:0004146 dihydrofolate reductase activity
molecular function GO:0008144 drug binding
molecular function GO:0003729 mRNA binding
molecular function GO:0050661 NADP binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005739 mitochondrion
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0046518 Chloroquine 319.18
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein