Showing entry for NADH-cytochrome b5 reductase 3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005525
Protein NameNADH-cytochrome b5 reductase 3
Uniport IdP00387
GeneCYB5R3
Gene Id1727
DomainFAD_binding_6; NAD_binding_1
Pfam PF00970   PF00175  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.1 Carbohydrate metabolism hsa00520 Amino sugar and nucleotide sugar metabolism
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0008015 blood circulation
Biological Process GO:0006695 cholesterol biosynthetic process
Biological Process GO:0019852 L-ascorbic acid metabolic process
Biological Process GO:0043312 neutrophil degranulation
Biological Process GO:0006805 xenobiotic metabolic process
molecular function GO:0043531 ADP binding
molecular function GO:0016208 AMP binding
molecular function GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H
molecular function GO:0071949 FAD binding
molecular function GO:0051287 NAD binding
cellular component GO:0035578 azurophil granule lumen
cellular component GO:0005737 cytoplasm
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0005576 extracellular region
cellular component GO:0005833 hemoglobin complex
cellular component GO:0005811 lipid droplet
cellular component GO:0016020 membrane
cellular component GO:0005741 mitochondrial outer membrane
cellular component GO:0005739 mitochondrion
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-196836 Vitamin C (ascorbate) metabolism
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors
R-HSA-196854 Metabolism of vitamins and cofactors
R-HSA-211859 Biological oxidations
R-HSA-211945 Phase I - Functionalization of compounds
R-HSA-6798695 Neutrophil degranulation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002895 BXGD000152 Anemia, Sickle Cell Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0004158 BXGD000261 Athetosis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007115 BXGD000432 Malignant neoplasm of thyroid Neoplasms; Endocrine System Diseases
C0010520 BXGD000675 Cyanosis Pathological Conditions, Signs and Symptoms
C0014877 BXGD000967 Esotropia Eye Diseases; Nervous System Diseases
C0018681 BXGD001214 Headache Pathological Conditions, Signs and Symptoms
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0025362 BXGD001866 Mental Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0025637 BXGD001879 Methemoglobinemia Hemic and Lymphatic Diseases
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026351 BXGD001900 Moderate intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026650 BXGD001913 Movement Disorders Nervous System Diseases
C0026826 BXGD001935 Muscle Hypertonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0032461 BXGD002356 Polycythemia Hemic and Lymphatic Diseases
C0033626 BXGD002412 Protein Deficiency Nutritional and Metabolic Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036857 BXGD002638 Severe intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0037354 BXGD002690 Smallpox Infections
C0038379 BXGD002752 Strabismus Eye Diseases; Nervous System Diseases
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0085584 BXGD003195 Encephalopathies Nervous System Diseases
C0151818 BXGD003480 Opisthotonus Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0154251 BXGD003710 Lipid Metabolism Disorders Nutritional and Metabolic Diseases
C0231807 BXGD004524 Dyspnea on exertion Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0235031 BXGD004714 Neurologic Symptoms Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235991 BXGD004802 Small for gestational age (disorder) Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications
C0241816 BXGD005115 Global brain atrophy
C0268193 BXGD005850 NADH cytochrome B5 reductase deficiency Hemic and Lymphatic Diseases
C0272087 BXGD006303 Congenital Methemoglobinemia Hemic and Lymphatic Diseases
C0279680 BXGD006680 Transitional cell carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0281788 BXGD006786 Biventricular hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0302511 BXGD006849 Small for gestational age fetus Pathological Conditions, Signs and Symptoms
C0346957 BXGD007836 Disseminated Malignant Neoplasm Neoplasms
C0410702 BXGD008447 Adolescent idiopathic scoliosis Musculoskeletal Diseases
C0424605 BXGD008535 Developmental delay (disorder) Mental Disorders
C0426970 BXGD008598 Spastic Quadriplegia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0427086 BXGD008605 Involuntary Movements Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0456070 BXGD008863 Growth delay
C0542514 BXGD009277 Blue sclera Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0557874 BXGD009444 Global developmental delay
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0740279 BXGD009973 Cerebellar atrophy
C0751093 BXGD010317 Dystonia, Limb Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0853087 BXGD010964 Nail abnormality Pathological Conditions, Signs and Symptoms
C0854373 BXGD011017 Lip discoloration
C0857841 BXGD011160 Vaccinia virus infection
C1269955 BXGD012005 Tumor Cell Invasion
C1277241 BXGD012110 Delayed myelination Mental Disorders
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1837397 BXGD014227 Severe global developmental delay
C1837461 BXGD014234 SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
C1861305 BXGD016027 TARSAL-CARPAL COALITION SYNDROME Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C2677328 BXGD017371 Cerebral hypomyelination
C2749559 BXGD017623 Methemoglobinemia, Type I Hemic and Lymphatic Diseases
C2749560 BXGD017624 Methemoglobinemia, Type Ii Hemic and Lymphatic Diseases
C2749561 BXGD017625 Nadh-Cytochrome B5 Reductase Deficiency, Type I Hemic and Lymphatic Diseases
C2749562 BXGD017626 Nadh-Cytochrome B5 Reductase Deficiency, Type Ii Hemic and Lymphatic Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3665425 BXGD019286 Hemoglobin M Disease Hemic and Lymphatic Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4022769 BXGD020994 Small basal ganglia
C4024936 BXGD021486 Temporal cortical atrophy
C4024965 BXGD021506 Frontal cortical atrophy
C4708104 BXGD023727 Autosomal recessive congenital methemoglobinemia type I Hemic and Lymphatic Diseases
C4733092 BXGD023907 estrogen receptor-negative breast cancer
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002616 Copper 63.55
BXGC0008101 Sodium nitrite 69
BXGC0046518 Chloroquine 319.18
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein