Showing entry for Aspartate aminotransferase, mitochondrial


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005560
Protein NameAspartate aminotransferase, mitochondrial
Uniport IdP00505
GeneGOT2
Gene Id2806
DomainAminotran_1_2
Pfam PF00155  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.5 Amino acid metabolism hsa00220 Arginine biosynthesis
1. Metabolism 1.5 Amino acid metabolism hsa00250 Alanine, aspartate and glutamate metabolism
1. Metabolism 1.5 Amino acid metabolism hsa00270 Cysteine and methionine metabolism
1. Metabolism 1.5 Amino acid metabolism hsa00330 Arginine and proline metabolism
1. Metabolism 1.5 Amino acid metabolism hsa00350 Tyrosine metabolism
1. Metabolism 1.5 Amino acid metabolism hsa00360 Phenylalanine metabolism
1. Metabolism 1.5 Amino acid metabolism hsa00400 Phenylalanine, tyrosine and tryptophan biosynthesis
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
1. Metabolism 1.0 Global and overview maps hsa01200 Carbon metabolism
1. Metabolism 1.0 Global and overview maps hsa01210 2-Oxocarboxylic acid metabolism
1. Metabolism 1.0 Global and overview maps hsa01230 Biosynthesis of amino acids
5. Organismal Systems 5.4 Digestive system hsa04975 Fat digestion and absorption
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006103 2-oxoglutarate metabolic process
Biological Process GO:0019470 4-hydroxyproline catabolic process
Biological Process GO:0006532 aspartate biosynthetic process
Biological Process GO:0006533 aspartate catabolic process
Biological Process GO:0006531 aspartate metabolic process
Biological Process GO:0008652 cellular amino acid biosynthetic process
Biological Process GO:0015908 fatty acid transport
Biological Process GO:0007565 female pregnancy
Biological Process GO:0006094 gluconeogenesis
Biological Process GO:0019551 glutamate catabolic process to 2-oxoglutarate
Biological Process GO:0019550 glutamate catabolic process to aspartate
Biological Process GO:0006536 glutamate metabolic process
Biological Process GO:0046487 glyoxylate metabolic process
Biological Process GO:0007595 lactation
Biological Process GO:0006107 oxaloacetate metabolic process
Biological Process GO:0045471 response to ethanol
Biological Process GO:0032868 response to insulin
Biological Process GO:0043278 response to morphine
Biological Process GO:0014850 response to muscle activity
molecular function GO:0016597 amino acid binding
molecular function GO:0019899 enzyme binding
molecular function GO:0042802 identical protein binding
molecular function GO:0016212 kynurenine-oxoglutarate transaminase activity
molecular function GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity
molecular function GO:0005543 phospholipid binding
molecular function GO:0030170 pyridoxal phosphate binding
molecular function GO:0003723 RNA binding
cellular component GO:0009986 cell surface
cellular component GO:0070062 extracellular exosome
cellular component GO:0005743 mitochondrial inner membrane
cellular component GO:0005759 mitochondrial matrix
cellular component GO:0005739 mitochondrion
cellular component GO:0043204 perikaryon
cellular component GO:0005886 plasma membrane
cellular component GO:0032991 protein-containing complex
cellular component GO:0030315 T-tubule
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1430728 Metabolism
R-HSA-1614558 Degradation of cysteine and homocysteine
R-HSA-1614635 Sulfur amino acid metabolism
R-HSA-389661 Glyoxylate metabolism and glycine degradation
R-HSA-70263 Gluconeogenesis
R-HSA-70326 Glucose metabolism
R-HSA-71291 Metabolism of amino acids and derivatives
R-HSA-71291 Metabolism of amino acids and derivatives
R-HSA-71387 Metabolism of carbohydrates
R-HSA-8963693 Aspartate and asparagine metabolism
R-HSA-8964539 Glutamate and glutamine metabolism
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001339 BXGD000041 Acute pancreatitis Digestive System Diseases
C0001363 BXGD000046 Acute vascular insufficiency of intestine (disorder) Digestive System Diseases
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003950 BXGD000243 Ascariasis Infections
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007115 BXGD000432 Malignant neoplasm of thyroid Neoplasms; Endocrine System Diseases
C0007133 BXGD000442 Carcinoma, Papillary Neoplasms
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007570 BXGD000467 Celiac Disease Digestive System Diseases; Nutritional and Metabolic Diseases
C0007959 BXGD000507 Charcot-Marie-Tooth Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0009021 BXGD000577 Clonorchiasis Infections
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009952 BXGD000639 Febrile Convulsions Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013238 BXGD000806 Dry Eye Syndromes Eye Diseases
C0014070 BXGD000887 Encephalomyelitis Infections; Nervous System Diseases
C0015397 BXGD000983 Disorder of eye Eye Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0015652 BXGD001010 Fascioliasis Digestive System Diseases; Infections
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0018129 BXGD001175 Graft Rejection
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019880 BXGD001351 Homocystinuria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases; Nervous System Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020557 BXGD001432 Hypertriglyceridemia Nutritional and Metabolic Diseases
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0021933 BXGD001524 Intussusception Digestive System Diseases
C0022104 BXGD001529 Irritable Bowel Syndrome Digestive System Diseases
C0022660 BXGD001571 Kidney Failure, Acute Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022661 BXGD001572 Kidney Failure, Chronic Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022665 BXGD001573 Kidney Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023787 BXGD001698 Lipodystrophy Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0025286 BXGD001850 Meningioma Neoplasms; Nervous System Diseases
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028259 BXGD002073 Nodule
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0028756 BXGD002083 Obesity, Morbid Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0030297 BXGD002204 Pancreatic Neoplasm Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0030424 BXGD002220 Paragonimiasis Infections
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0035243 BXGD002522 Respiratory Tract Infections Infections; Respiratory Tract Diseases
C0036323 BXGD002595 Schistosomiasis Infections
C0036330 BXGD002597 Schistosomiasis mansoni Infections
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038586 BXGD002772 Substance Use Disorders Chemically-Induced Disorders; Mental Disorders
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085207 BXGD003140 Gestational Diabetes Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0085413 BXGD003171 Polycystic Kidney, Autosomal Dominant Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0085584 BXGD003195 Encephalopathies Nervous System Diseases
C0151468 BXGD003424 Thyroid Gland Follicular Adenoma Neoplasms; Endocrine System Diseases
C0155626 BXGD003806 Acute myocardial infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0156149 BXGD003839 Gastrointestinal tract vascular insufficiency Digestive System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0201899 BXGD004056 Aspartate aminotransferase measurement
C0205647 BXGD004099 Follicular adenoma Neoplasms
C0206669 BXGD004229 Hepatocellular Adenoma Digestive System Diseases; Neoplasms
C0206682 BXGD004237 Follicular thyroid carcinoma Neoplasms
C0220994 BXGD004357 Hyperammonemia Pathological Conditions, Signs and Symptoms
C0232466 BXGD004543 Feeding difficulties
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0238461 BXGD004936 Anaplastic thyroid carcinoma Neoplasms
C0238462 BXGD004937 Medullary carcinoma of thyroid Neoplasms; Endocrine System Diseases
C0242339 BXGD005150 Dyslipidemias Nutritional and Metabolic Diseases
C0260037 BXGD005227 Multiple tumors Neoplasms
C0264714 BXGD005416 Acute heart failure Cardiovascular Diseases
C0265706 BXGD005570 Gastroschisis Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0278877 BXGD006608 Adult Meningioma Neoplasms; Nervous System Diseases
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0281361 BXGD006774 Adenocarcinoma of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0314719 BXGD006890 Dryness of eye Eye Diseases
C0338106 BXGD007167 Adenocarcinoma of colon Digestive System Diseases; Neoplasms
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376618 BXGD008003 Endotoxemia Pathological Conditions, Signs and Symptoms; Infections
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0524910 BXGD009248 Hepatitis C, Chronic Digestive System Diseases; Infections
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0555198 BXGD009432 Malignant Glioma Neoplasms
C0557874 BXGD009444 Global developmental delay
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598589 BXGD009667 Inherited neuropathies Nervous System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0919747 BXGD011439 Cytokine storm
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1262211 BXGD011876 Diarrhoea predominant irritable bowel syndrome
C1285162 BXGD012167 Degenerative disorder Pathological Conditions, Signs and Symptoms
C1302401 BXGD012303 Adenoma of large intestine Digestive System Diseases; Neoplasms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332201 BXGD012502 Adult Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1442826 BXGD013059 Neonatal necrotizing enterocolitis Digestive System Diseases
C1449563 BXGD013086 Cardiomyopathy, Familial Idiopathic Cardiovascular Diseases
C1511789 BXGD013183 Desmoplastic
C1527336 BXGD013271 Sjogren's Syndrome Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1608408 BXGD013434 Malignant transformation
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1762616 BXGD013753 Meningioma, benign, no ICD-O subtype Neoplasms; Nervous System Diseases
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1836440 BXGD014115 Increased serum lactate Nutritional and Metabolic Diseases
C1859486 BXGD015901 BIETTI CRYSTALLINE CORNEORETINAL DYSTROPHY Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1861453 BXGD016049 Pseudohyperkalemia Cardiff Nutritional and Metabolic Diseases
C1868889 BXGD016540 Irritable bowel syndrome characterized by constipation Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C2004435 BXGD016871 Vascular insufficiency of intestine Digestive System Diseases; Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2243080 BXGD017009 Intestinal necrosis Digestive System Diseases
C2316810 BXGD017030 Chronic kidney disease stage 5 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2609414 BXGD017182 Acute kidney injury Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2939175 BXGD018175 Meconium ileus Digestive System Diseases
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3852986 BXGD019817 Nonocclusive Mesenteric Ischemia Digestive System Diseases; Cardiovascular Diseases
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C4014430 BXGD020146 EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 21
C4022810 BXGD021005 Abnormality of nervous system morphology Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C4082937 BXGD022095 Necrotizing enterocolitis in fetus OR newborn Digestive System Diseases
C4524040 BXGD023086 Atherogenic dyslipidaemia
C4721773 BXGD023768 Postoperative cognitive dysfunction
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0006162 L-Glutamic acid 147.13
BXGC0006186 L-Aspartic acid 133.1
BXGC0006271 L-Cysteine 121.16
BXGC0043088 Pyridoxal Phosphate 247.02
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein